Microcystic adnexal (sclerosing sweat duct) carcinoma of intraoral minor salivary gland origin: an extracutaneous adnexal neoplasm?

Sclerosing Microcystic Adenocarcinoma: Report of a Rare Case and Review of Literature

“…The differential diagnoses of sclerosing microcystic adenocarcinoma include neoplasms like squamous cell carcinoma, adenoid cystic carcinoma, low grade mucoepidermoid carcinoma, tubular pattern of polymorphous low-grade adenocarcinoma (PLGA) [8], and secretory carcinoma and reactive lesion like chronic sclerosing sialadenitis. Distinguishing this tumor from squamous cell carcinoma is very important since it will impact the management significantly.…”

Magnetic resonance imaging findings of sclerosing microcystic adenocarcinoma: A case report and review of the literature

“…MAC is an indolent, locally aggressive, and deeply infiltrative tumor with a high propensity for perineural invasion [ 2 , 3 ] and is most common in the head and neck region [1] . MAC rarely occurs in extracutaneous locations, including the oral cavity and other mucosal head and neck regions where adnexal keratinocytes do not exist [4] , [5] , [6] , [7] , [8] , [9] , [10] . In 2016, Mills et al.…”

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term

“…Following a report by Johnston and Toker [7] in 1982, a number of definite or possible cases of salivary microcystic adenocarcinoma with sclerosing features were documented under a variety of names [1][2][3][4][5][6][8][9][10]. Without much supportive rationale, sclerosing microcystic adenocarcinoma is now only the designation that has survived this terminological conundrum [1,5].…”

“…Without much supportive rationale, sclerosing microcystic adenocarcinoma is now only the designation that has survived this terminological conundrum [1,5]. Readers interested in the previously discarded terms are referred to two review articles [5,9]. It is clear that Rosebush et al [6] initially introduced, in abstract form, the term "microcystic adenocarcinoma."…”

“…Obviously, Rosebush et al [6] were very aware of the significance of stromal sclerosis, and were undoubtedly among the first to appreciate the considerable morphological overlap between mucosal microcystic adenocarcinoma and cutaneous microcystic adnexal carcinoma [2]. Although the presence of perineural and/or intraneural epithelium is usually associated with microcystic adenocarcinoma [1,[3][4][5][8][9][10], there was no mention of neurotropism. Nevertheless, their many original observations provided the conceptual framework for this entity.…”