Microcystic Adnexal Carcinoma of the Vulva

Buhl, Allen E.; Landow, Shoshana; Lee, Yi-Chun; Holcomb, Kevin; Heilman, Edward; Abulafia, Ovadia

doi:10.1006/gyno.2001.6300

Cited by 29 publications

(28 citation statements)

References 14 publications

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“…2 Çok na dir ola rak ge ni tal böl ge de yer le şir. 3 Li te ra tür de or bi ta da bil di ril miş ol gu lar da var dır. 4 Sık lık la 0.5-2 cm ara sın da, sert, sı nır la rı be lir siz, plak ve ya nodül şek lin de dir.…”

Section: Discussionunclassified

“…Turkiye Klinikleri J Med Sci 2010;30 (3) Mik ro kis tik ad nek si yal kar si nom da ki de ri ne in fil tra tif bü yü me eği li mi, pe ri nö ral in vaz yon ve duk tal di fe ran si as yo nun var lı ğı des mop las tik tri ko e pi telyo ma ve tri ko a de no ma ay rı mın da önem li dir. 2 Desmop las tik tri ko e pi tel yo ma da tü mör çev re sin de ki stro mal hüc re ler de be lir gin CD34 ile bo yan ma göz-Turkiye Klinikleri J Med Sci 2010;30 (3) 1102 Dağlar ve ark.…”

Section: Discussionunclassified

“…2 Desmop las tik tri ko e pi tel yo ma da tü mör çev re sin de ki stro mal hüc re ler de be lir gin CD34 ile bo yan ma göz-Turkiye Klinikleri J Med Sci 2010;30 (3) 1102 Dağlar ve ark.…”

Section: Discussionunclassified

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Microcystic Adnexal Carcinoma: Case Report

Dağlar¹,

Ergül²,

Kulaçoğlu³

2010

Turkiye Klinikleri J Med Sci

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Section: Discussionunclassified

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Microcystic Adnexal Carcinoma: Case Report

Dağlar¹,

Ergül²,

Kulaçoğlu³

2010

Turkiye Klinikleri J Med Sci

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“…Other ethnic groups may also be affected, and at least 50 Japanese [ 10 ] and 7 African American patients have been reported in the literature [ 9,[11][12][13][14][15] .…”

Section: Epidemiologymentioning

confidence: 98%

Microcystic Adnexal Carcinoma

Παλαμάρας

Barlow

2011

Mohs Micrographic Surgery

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Microcystic adnexal carcinoma (MAC) is a rare adnexal tumor often found on the head and neck and usually presenting as an ill-defi ned, yellowish, or faintly erythematous plaque. It is characterized by aggressive local infi ltration and has a high propensity for perineural invasion (PNI).Most cases have been reported in white patients aged 40-60 years, and there is no sexual predilection. The tumor also occurs in other ethnic groups and across a much wider age range.An adequately sized biopsy is necessary for diagnosis. Surgery is the treatment of choice. The poorly defi ned clinical margins and propensity for perineural spread make Mohs micrographic surgery (MMS) preferable to standard surgical excision. When nerve involvement is present, MMS with formalin-fi xed, paraffi n-embedded sections should be considered.The prognosis is good, and the 10-year survival rate is higher than 85%. Metastases are rare.

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“…Diagnostic difficulties are compounded when MAC arises in alternate locations where it may not come to mind as a consideration. For instance, MAC has been documented in the breast and the vulva, where it can be mistaken for more conventional adenocarcinomas of these locales [7,8]. Other potentially problematic primary sites include head and neck locations outside the skin.…”

Section: Introductionmentioning

confidence: 99%

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Mills

Policarpio-Nicholas

Agaimy

et al. 2016

Head and Neck Pathol

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Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52.6 years (range 41-73 years). Location included the tongue (n = 2), the floor of the mouth (n = 2), and the nasopharynx/clivus (n = 1). One occurred after radiation therapy and another occurred in the setting of immune compromise. Immunohistochemistry highlighted a dual cell population with luminal cells showing positivity for high and low-molecular weight keratins and surrounding myoepithelial cells showing S100 and smooth muscle actin staining. No cases had nodal involvement, and the single patient with clinical follow-up was alive and free of disease 34 months after diagnosis and definitive radiochemotherapy. Differential diagnoses for all cases diverged from those provoked by MAC in the skin and included a variety of salivary gland neoplasms such as adenoid cystic carcinoma, polymorphous low grade adenocarcinoma, and mucoepidermoid carcinoma. Recognition of sclerosing microcystic adenocarcinoma in the head and neck mucosa is critical given its bland appearance and subtle infiltration pattern, infrequency of nodal involvement, and behavioral differences from the other entities on the differential.Keywords Sclerosing microcystic adnexal carcinoma Á Microcystic adnexal carcinoma Á MAC Á Head and neck Á Salivary gland carcinoma Á Mucosal

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Microcystic Adnexal Carcinoma of the Vulva

Cited by 29 publications

References 14 publications

Microcystic Adnexal Carcinoma: Case Report

Microcystic Adnexal Carcinoma: Case Report

Microcystic Adnexal Carcinoma

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

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