Microcystic Adnexal Carcinoma

Abstract

Background: Microcystic adnexal carcinoma, or sclerosing sweat duct carcinoma, is an uncommon cutaneous neoplasm associated with extensive local invasion. The standard of care with regard to the best excisional method in treating microcystic adnexal carcinoma has not been established.Objectives: To perform a retrospective study comparing patients treated by Mohs micrographic surgery with those treated by wide excision and to elucidate the epidemiological features of microcystic adnexal carcinoma. Patients and Methods:A retrospective analysis of a case series involving 48 primary and referral patients diagnosed as having microcystic adnexal carcinoma using standardized criteria. All cases were reviewed by the same dermatopathologists.Results: Microcystic adnexal carcinoma predominantly affects the left side of the face of middle-aged women. Microcystic adnexal carcinoma is misdiag-

Microcystic Adnexal Carcinoma: Review of 51 Japanese Patients

“…Like their study [5], both sexes were equally affected in the Japanese: 26 (51%) occurring in men and 25 (49%) in women. There was little difference between the right and left sides in the Japanese patients, although Chiller et al [4]described MAC that predominantly affected the left side of the face of middle-aged women. Although this neoplasm was considered to occur predominantly in Caucasians [5], our review shows that it is more common in Japanese subjects than previously observed.…”

“…MAC is often misdiagnosed clinically or pathologically as a benign or malignant tumor [1, 4, 5, 9]. The histological differential diagnoses include benign and malignant tumors such as trichoadenoma, syringoma, papillary eccrine adenoma, desmoplastic trichoepithelioma, morpheiform basal cell carcinoma, squamous cell carcinoma and metastatic breast carcinoma [1, 5].…”

“…The initial biopsy specimen must be large and deep enough to demonstrate the identifying histologic features [1, 4, 5, 9]. …”

“…Microcystic adnexal carcinoma (MAC) is an aggressive, locally destructive cutaneous neoplasm with a high rate of recurrence [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11], which is said to occur predominantly in Caucasians. However, the number of cases in Japanese subjects seems to have recently been increasing.…”

Fine Needle Aspiration Cytology of Eccrine Skin Adnexal Tumors

“…Microcytic adnexal carcinoma: is cytologically characterized by clusters of uniform keratinocytes, pleomorphic epithelial cells with ductal differentiation and dense collagenous stromal fragments [2,19,20].…”