Microcystic adenoma of the pancreas

Lal, Aseem; Bourtsos, Eleni P.; DeFrias, Denise V. S.; Nemcek, Albert A.; Nayar, Ritu

doi:10.1002/cncr.20487

Cited by 40 publications

(6 citation statements)

References 23 publications

(19 reference statements)

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“…Contaminating glandular cells may be interpreted as atypical cells or neoplastic mucinous cyst. 8,10 In a retrospective morphologic study, only 5/51 (10%) cases were correctly identified as SCA on EUS-FNA. 11 Rest of the cases was either diagnosed, as benign ductal and acinar cells not otherwise specified diagnostic, pseudocyst, or mucinous cystic neoplasm (MCN).…”

Section: Pitfallsmentioning

confidence: 99%

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Approach to FNA of Pancreatic Cysts

Jhala

2022

Advances in Anatomic Pathology

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Pancreatic cysts are increasingly detected on imaging studies. Accurate determination of the type of cyst is important to provide appropriate care for patients. It is also very clear that not one single modality can provide adequate diagnostic information for pancreatic cysts. A multimodal approach to the diagnosis of pancreatic cyst is the key. This review will highlight how to approach to fine-needle aspiration of pancreatic cysts. The review will also highlight salient features of common neoplastic pancreatic cysts along with the use of ancillary testing which includes biochemical testing, commonly utilized molecular tests, and/or immunohistochemical tests to provide an accurate diagnosis.

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Section: Pitfallsmentioning

confidence: 99%

“…7 Cytoplasm is scant, pale, foamy, and vacuolated. 7,8 This later finding may mimic macrophages and may result in a false-negative diagnosis.…”

Section: Cytologymentioning

confidence: 99%

Approach to FNA of Pancreatic Cysts

Jhala

2022

Advances in Anatomic Pathology

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“…A “honeycomb” appearance on CT or MRI, associated with a central scar that may or may not be calcified, is characteristic for microcystic variant 16, 17, 22, 29–31 . However, the diagnosis is often not accomplished preoperatively by imaging studies.…”

Section: Serous Neoplasmsmentioning

confidence: 99%

“…The cytoplasm is usually cleared or vacuolated. However, the cells are frequently stripped of cytoplasm, showing only small, round nuclei with fine but dense, homogenous nuclear chromatin 31, 36, 39 .…”

Section: Serous Neoplasmsmentioning

confidence: 99%

Benign Tumors and Tumorlike Lesions of the Pancreas

Basturk

Aşkan

2016

Surgical Pathology Clinics

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Synopsis The pancreas is a complex organ that may give rise to large number of neoplasms and non-neoplastic lesions. This article will focus on benign neoplasms such as serous neoplasms as well as tumor-like (pseudotumoral) lesions that may be mistaken for neoplasm not only by clinicians and radiologists, but also by pathologists. The family of pancreatic pseudotumors, by a loosely defined conception of that term, includes a variety of lesions including heterotopia, hamartoma, and lipomatous pseudohypertrophy. Autoimmue pancreatitis (covered in chronic pancreatitis chapter) and paraduodenal (“groove”) pancreatitis may also lead to pseudotumor formation. Knowledge of these entities will help in making an accurate diagnosis.

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“…This did not include reports of the use of FNA for the diagnosis that lack a description of the cytomorphologic features of the case(s). These reports are collected, reviewed and compared with the current findings [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]. …”

Section: Methodsmentioning

confidence: 99%

Serous Cystadenoma of the Pancreas with Endoscopic Ultrasound Fine Needle Aspiration Biopsy and Surgical Correlation

Collins

2013

Acta Cytologica

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Objectives: Endoscopic ultrasound (EUS) fine needle aspiration (FNA) biopsies are commonly used to diagnose tumors of the pancreas. Serous cystadenoma (SCA) is a benign neoplasm that is uncommon and accounts for 1-2% of all pancreatic neoplasms. Study Design: Surgically excised SCAs with preoperative EUS FNA biopsy over a 10-year span were identified. Clinical data were collected, and cytomorphologic features reviewed retrospectively and correlated with surgical excision data. Original cytopathologic diagnoses and retrospectively reviewed cytomorphology features were recorded. Results: Seventeen patients were identified. Original EUS FNA interpretation included 1 ‘unsatisfactory', 9 ‘negative for malignancy' and 7 ‘atypical' or greater; however, all cases were categorized as benign/negative or nondiagnostic on retrospective review. The cases were hypocellular and possessed variable (rare to few-moderate) groups of bland cuboidal epithelial cells embedded in granular debris. Mucosal sampling was present (7/17) and cell blocks were acellular (5/17). Conclusion: This is a large series of pancreas SCAs subjected exclusively to EUS FNA biopsy where all cases had surgical excision confirmation. The 17 cases had hypocellular aspirate smears with the majority showing few bland epithelial cells; however, this can limit definitive diagnosis based on the cytomorphologic evaluation alone. The aspirate smear pattern of EUS FNA of SCAs of the pancreas supports a benign/negative or nondiagnostic categorization.

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Microcystic adenoma of the pancreas

Abstract: BACKGROUND.Cytology literature on pancreatic microcystic adenoma is sparse. It is

Cited by 40 publications

References 23 publications

Approach to FNA of Pancreatic Cysts

Approach to FNA of Pancreatic Cysts

Benign Tumors and Tumorlike Lesions of the Pancreas

Serous Cystadenoma of the Pancreas with Endoscopic Ultrasound Fine Needle Aspiration Biopsy and Surgical Correlation

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