Microcomputer reconstruction of pancreaticobiliary embryogenesis

Wind, Gary; Allely, Eric; Jenkins, Donald H.

doi:10.1002/ca.980020403

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Smatra se da razviće pankreasa započinje u petoj nedelji embrionalnog perioda razvoja nastankom dorzalnog i ventralnog pankreasnog divertikuluma (pupoljka) na distalnom kraju prednjeg creva, budućeg duodenuma (gemma pancreatica dorsalis et ventralis) (11). Po nekim autorima pankreatobilijarne strukture ljudskog embriona se zapravo razvijaju iz pupoljaka endoderma duodenuma u četvrtoj nedelji embrionalnog razvoja, tako da se već 30-35 dana uočavaju dve odvojene mase ćelija koje formiraju dva pupoljka (15). Dorzalni pupoljak razvija se rapidno i širi se dorzokranijalno u mezogastrijum, levo od vitelinske vene.…”

Section: Uvodunclassified

Morphological analysis of a structures of prenatal pancreas in human

Filipović¹,

Filipovič²,

Mandic³

et al. 2016

Praxis Med

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Kao mešovita egzokrino-endokrina žlezda pankreas ima izuzetno važnu ulogu u digestivnom traktu. Njegov egzokrini deo, svojim sokom koji izliva u duodenum, a koji sa sobom nosi više od 20 pankreasnih enzima, omogućava normalan proces varenja. Endokrini deo ove žlezde, koga čine ostrvca-insule, aktivno učestvuje u metabolisanju materija u čovečjem organizmu, lučeći dva važna hormona-insulin i glukagon. Zbog svoje lokalizacije, pankreas predstavlja izuzetno nepristupačan organ za fizički pregled. Veliki je broj savremenih kliničkih metoda za praćenje promena na ovom organu ali i savremeni klinički rad zahteva detaljno poznavanje morfoloških karakteristika ove žlezde. Materijal je uzet sa kadavera fetusa i novorođenčadi na institutu sa za patologiju Medicinskog fakulteta. Preparate pankreasa smo razvrstali u grupe u odnosu na uzrast (od 3 meseca do neonatusa) i kranio-sakralnu (KS) dužinu. Nakon dehidracije i kalupljenja preparati su u vidu stepenaste serije rezani u debljini između 6 i 10 mikrona. Osim standardnih metoda bojenja, neki preparati su, radi identifikacije insula, bojeni po Grimelijusu. U ovom istraživanju determinisali smo morfološke promene tkiva prenatalnog pankreasa od trećeg meseca intrauterinog razvoja do kraja fetusnog doba i ustanovili dinamiku promena parenhima i strome. Funkcionalne delove pankreasa mogli smo razlikovati već u 10-11 nedelji fetusnog perioda razvića. Kod pankreasa u prvom trimestru trudnoće, uočili smo porast parenhimskih elemenata na račun redukcije strome, koja je nešto više izražena u području interlobulusnih prostora koji jasno diferentuju lobuluse. Početkom drugog trimestra trudnoće u razvojnom pankreasu se zapažaju značajne promene. Jasno se uočava lobulusna građa pankreasa. Acinusi egzokrinog pankreasa su jasno diferentovani i nalaze se u veoma bliskom kontaktu, s obzirom da je stroma među njima jako redukovana. U okviru gotovo svih lobulusa jasno su izražena Langerhansova ostrvca, koja su umnožena, različite veličine, odvojena od egzokrinog dela slabo izraženim vezivnim tkivom. U grupi nedonesene dece ustanovili smo da je histološka slika pankreasa veoma slična onoj pri kraju fetalnog perioda.

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Section: Uvodunclassified

Morphological analysis of a structures of prenatal pancreas in human

Filipović¹,

Filipovič²,

Mandic³

et al. 2016

Praxis Med

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show abstract

“…Examples of these models include reconstructions from serial sections at the microscopic (Wind et al, 1989;Denny et al, 1990) and macroscopic (Stimac et al, 1988;McCracken and Spurgeon, 1991;) levels of resolution, coordinated reconstructions at both levels (McLean and Prothero, 1987), and 3-D rendered images reconstructed directly from radiological data (Hirsch et al, 1989;Wallis and Miller, 1991).…”

Section: Introductionmentioning

confidence: 99%

Computer‐generated three‐dimensional reconstruction of the mediastinm correlated with sectional and radiological anatomy

et al. 1992

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We describe a three-dimensional computer-generated model of the human mediastinum. Contours were manually traced from photographs of a serially sectioned, unfixed frozen cadaver block. Using software developed in-house, the contours were digitized, automatically assembled and placed in registration, and displayed on a high performance graphics workstation as surfaced images. The model thus produced has advantages over traditional representations of anatomical structures; it is realistic, accurate, efficient, and flexible. Each anatomical component of the mediastinum is stored as a separate file in the computer and can be selectively accessed, displayed, and manipulated, allowing the model to be disassembled, reassembled, dissected, and viewed in any orientation. The model can be divided into a series of transversely cut "slabs," the surfaces of which correlate with the anatomy displayed in the original cryosections and with radiological scans, thus permitting 2-D sectional anatomy to be viewed in the context of the 3-D model. Animation of the model can be accomplished by recording pre-planned scripts onto videodiscs. The videodiscs serve as image archives that can be viewed in an interactive, selfpaced manner or accessed from a computer-based multimedia system that is being developed by the Digital Anatomist Program. Anatomical reconstructions based on datasets of x-, y-, z-coordinates have potential clinical applications as models that can be displayed to match the sectional planes of radiological images. The mediastinum model we describe is part of a large image database being developed by the Digital Anatomist Program that will form the spatial component of a knowledge base in structural biology. 0 1992 Wiley-Liss, Inc.

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Computerized modelling of nasal capsular morphogenesis in prenatal primates

1993

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Descriptive and comparative analysis of primate chondrocranial anatomy relies on three-dimensional reconstructions of embryonic and fetal tissues. Typically, reconstructions are accomplished using manual techniques that are time-consuming and laborious. Recent advances in computer technology permit computerized reconstruction, but most available systems d o not interpolate surfaces so models consist of solid polygons without intervening surfaces. The purpose of this paper is to describe a new computerized surface-modelling routine for the rapid and reliable reconstruction of nasal capsular anatomy in prenatal primates as well as to apply this system for the comparative analysis of nasal morphogenesis. Models of the nasal capsule and anterior cranial base are generated for a developmental series of prenatal specimens including Microcebus murinus, Macaca mulatta, and Homo sapiens. Results show that the computerized system reconstructs complex morphologies rapidly and automatically. T h e computerized models display higher anatomical resolution than that available from reconstructions generated through manual methods or algorithms used in commercially available systems and they can be viewed on a personal computer. Comparative anatomical analysis reveals that the nasal floor is highly specialized in Microcebus which displays a zona annularis. However, complexity in this region is reduced in Macaca and Homo which probably corresponds to a morphological reduction, but not elimination, of the vomeronasal organ and associated StfuCtUreS. 0 1993 Wilev-L,iss, Inc.

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Microcomputer reconstruction of pancreaticobiliary embryogenesis

Cited by 5 publications

References 7 publications

Morphological analysis of a structures of prenatal pancreas in human

Morphological analysis of a structures of prenatal pancreas in human

Computer‐generated three‐dimensional reconstruction of the mediastinm correlated with sectional and radiological anatomy

Computerized modelling of nasal capsular morphogenesis in prenatal primates

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