Microcoated wire sensors for the determination of anticancer drugs cyclophosphamide and ifosphamide in the presence of their degradates

Hassan, Saad S. M.; Amer, M. M.; El-Fatah, Soheir A. Abd; El-Kosasy, Amira M.

doi:10.1016/s0039-9140(98)00008-3

Cited by 28 publications

(14 citation statements)

References 13 publications

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“…The separate solution method 18,19) with aˆxed concentration of the interferent (10 -3 M) was used for evaluation of the selectivity. The results obtained by the developed sensors, Table 2, showed reasonable selectivity for the two sensors for tiapride hydrochloride in presence of any of the mentioned interferent.…”

Section: Resultsmentioning

confidence: 99%

“…19) Preparation of Tiapride-tetraphenyl Borate Membrane Ten milliliter of 10 -2 M tiapride hydrochloride aqueous solution was mixed with 10 ml of a saturated aqueous solution of sodium tetraphenyl borate. The resulting precipitate wasˆltered, washed with cold water, allowed to dry at room temperature then grounded toˆne powder.…”

Section: Procedures Precipitation-based Technique For the Preparationmentioning

confidence: 99%

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Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Metwally

2007

YAKUGAKU ZASSHI

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The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for determination of tiapride in presence of its degradation products are described. The sensors are based on the ion association complexes of tiapride cation with sodium tetraphenyl borate (Tia-TPB) [sensor 1]) or ammonium reineckate (Tia-R) [sensor 2] counter anions as ion exchange sites in PVC matrix. The performance characteristics, sensitivity and selectivity of these electrodes in presence of tiapride degradation products were evaluated according to IUPAC recommendations. It reveals a fast, stable and linear response for tiapride over the concentration range 10 -5  10 -2 M with cationic slopes of 28.997 and 30.580 mV per concentration decade with sensors 1 and 2, respectively. These sensors exhibit fast response time (20 30 s), low quantitation limit (4.5×10 -6 and 3.6×10 -6 , respectively), and good stability (6 8 weeks). The direct potentiometric determination of tiapride hydrochloride using the proposed sensors gave average recoveries of 99.95±0.678 and 99.92±1.157 for sensors 1 and 2, respectively. The sensors are used for determination of tiapride hydrochloride, in pure form, in presence of its degradation products in tablets, and in plasma. Validation of the method shows suitability of the proposed sensors for use in the quality control assessment of tiapride hydrochloride and for routine analysis as stability indicating method. The developed method was found to be simple, accurate and precise when compared with a reference company spectrophotometric method.

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Section: Resultsmentioning

confidence: 99%

Section: Procedures Precipitation-based Technique For the Preparationmentioning

confidence: 99%

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Metwally

2007

YAKUGAKU ZASSHI

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“…The petri dish was covered with a filter paper and left to stand for one hour to allow slow evaporation of the solvent, producing a thick homogeneous master coating PVC solution [46]. [44,47] …”

Section: Preparation Of Electroactive Coating Membranementioning

confidence: 99%

The use of calixarene as ionophores in potentiometric ion-selective electrodes of naftidrofuryl oxalate using microsized membrane sensors for kinetic study of naftidrofuryl (NFT) degradation

El-Sayed

2013

Eur. J. Chem.

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KEYWORDSNovel miniaturized polyvinyl chloride membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of naftidrofuryl oxalate. The naftidrofuryl oxalate sensors were based on the formation of an ionassociation complex between the drug cation and tetrakis-(4-chlorophenyl)borateanionic exchanger as electroactive material and sulfocalix-8-arene as ionophore dispersed in a polyvinyl chloride matrix. Linear responses of 10 -2 -10 -6 M and 10 -2 -10 -5 M with cationic slopes of 56.9 mV and 54.1 mV over the pH range 2-5 were obtained by using the naftidrofuryl oxalate-coated graphite (Sensor 1) and platinum wire (Sensor 2) membrane sensors, respectively. The utility of 4-sulfocalix-8-arene as ionophore had a significant influence on increasing the membrane sensitivity and selectivity. The methods were also used to determine the intact drug in the presence of it's degradate in Praxilene ® tablets, plasma and cerebrospinal fluid with good recovery. Sensor 1 was used to study the kinetics of naftidrofuryl oxalate alkaline degradation that was found to follow a pseudo first-order reaction. The activation energy could be estimated from the Arrhenius plot to be 12.572 Kcal/mol. PotentiometryCerebrospinal fluid 4-Sulfocalix-8-arene Naftidrofuryl oxalate Stabilityindicating method Tetrakis-(4-chlorophenyl)borate

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“…The inherent advantages of ion selective electrodes (ISEs) are simplicity, short time measurement, low cost, adequate precision and accuracy, adequate detection limit, wide analytical range, and particularly the ability to measure the activity of various species selectivity, and in most cases, without prior separation of the target molecule from the formulation matrix [18][19][20]. These make ISE potentiometry very attractive for chemical and pharmaceutical analysis.…”

Section: Introductionmentioning

confidence: 99%

Novel PVC-based coated graphite electrode for selective determination of quinoline yellow

Rouhani

Haji-ghasemi

2009

JICS

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Novel coated graphite electrode (CGE) for the determination of quinoline yellow (QY), an artificial food colorant, was evaluated based on the use of tetraphenylphosponium-QY ion-pair complex as the electroactive substance. The electrode revealed linear emf-pQY response over wide concentration ranges (1.0 × 10 -1 ~ 5.0 × 10 -5 M ) with a slope -30.1 ± 0.2 mV decade -1 and a limit of detection of 4.0 × 10 -5 M. The electrode showed good stability, reproducibility and fast response (<5 s). It can be used in wide pH range (4.7-10.7) and was successfully applied to determination of quinoline yellow in artificial mixtures and commercial soft drinks. The results obtained with the electrode were in good agreement with the value obtained by using HPLC measurements, as an official method.

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Microcoated wire sensors for the determination of anticancer drugs cyclophosphamide and ifosphamide in the presence of their degradates

Cited by 28 publications

References 13 publications

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

The use of calixarene as ionophores in potentiometric ion-selective electrodes of naftidrofuryl oxalate using microsized membrane sensors for kinetic study of naftidrofuryl (NFT) degradation

Novel PVC-based coated graphite electrode for selective determination of quinoline yellow

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