Microcirculatory Studies of Frostbite Injury

Zook, N; Hussmann, J.; Brown, Richard D.; Russell, R; Kucan, John O.; Roth, Allan C.; Suchy, Hans

doi:10.1097/00000637-199803000-00009

Cited by 63 publications

(38 citation statements)

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“…Edema, as a sensitive indicator for endothelium integrity loss due to the direct frostbite injury, was most prominent directly after frostbite. Edema formation began minutes post frostbite and underlines former findings of endothelial cell damage [9,16,22].…”

Section: Discussionsupporting

confidence: 75%

“…The second one is the reperfusion-damage during rewarming [5]. Red cells, platelets and leukocytes in interaction with the injured endothelium cause microvascular thrombosis [1,8,9]. Additionally, free radicals and arachidonic acid metabolites, like PGF 2a and thromboxane A 2 , are released, further aggravating vasoconstriction and thrombosis [1,10].…”

Section: Introductionmentioning

confidence: 99%

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Influence of ISDN, l-NAME and selenium on microcirculation, leukocyte endothelium interaction and angiogenesis after frostbite

Goertz¹,

Haddad²,

Lohe³

et al. 2015

Burns

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Influence of ISDN, l-NAME and selenium on microcirculation, leukocyte endothelium interaction and angiogenesis after frostbite

Goertz¹,

Haddad²,

Lohe³

et al. 2015

Burns

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“…In particular, damage to vascular endothelium caused by freezing, and reperfusion injury occurring during and after thawing, may lead to vasodilation and leaky vasculature. This reperfusion of damaged blood vessels, which has been demonstrated experimentally, may play a central role in the distinct contrast enhancement patterns observed following cryoablation in this study [10][11][12].…”

Section: Discussionsupporting

confidence: 53%

MRI contrast enhancement of malignant liver tumours following successful cryoablation

et al. 2011

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“…32 Tumor vessels could also suffer from ischemia-reperfusion injury which was indicated in frostbite by other studies. 22,53 During reperfusion, the oxygen delivery caused free radical formation. By peroxidation of the lipids in the endothelial membrane, the vessel wall integrity was destroyed.…”

Section: Discussionmentioning

confidence: 99%

Study on Tumor Microvasculature Damage Induced by Alternate Cooling and Heating

et al. 2008

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Tumor vasculature damage induced by various thermal treatments has been studied in vivo via laser confocal microscopy. Murine mammary carcinoma 4T1 was implanted in the nude mice dorsal skin fold window chamber. The implanted tumor was treated by alternate cooling and heating. Results showed that the treatment was much more effective as compared with that of cooling or heating alone, especially in damaging the tumor vasculature. In general, tumor vascular response to thermal stimuli was heterogeneous. All the treatments of hyperthermia at 42 degrees C (for 1 h), alternate cooling at 1 degrees C and heating at 42 degrees C (for 1/2 h each) and that of -10 degrees C/42 degrees C (for 1/2 h each) enhanced liposome extravasation. Pre-cooling tumor at 1 degrees C preserved most of the vascular integrity but partially inhibited the effect of post-hyperthermia at 42 degrees C. On the other hand, cooling at -10 degrees C for 1/2 h before heating at 42 degrees C caused severe vessel damage. Histo-pathological analyses further confirmed the effect as rare tumor vessel recurrence and large necrotic tumor tissue areas shown on the 7th day after the treatment.

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Microcirculatory Studies of Frostbite Injury

Cited by 63 publications

References 0 publications

Influence of ISDN, l-NAME and selenium on microcirculation, leukocyte endothelium interaction and angiogenesis after frostbite

Influence of ISDN, l-NAME and selenium on microcirculation, leukocyte endothelium interaction and angiogenesis after frostbite

MRI contrast enhancement of malignant liver tumours following successful cryoablation

Study on Tumor Microvasculature Damage Induced by Alternate Cooling and Heating

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