Microcirculatory Responses to Hypovolemic Shock

Szopinśki, Jacek; Kusza, Krzysztof; Semionow, Maria

doi:10.1097/ta.0b013e31823a05b5

Cited by 19 publications

(15 citation statements)

References 87 publications

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“…33 Venular responses are poorly defined and controversial 35 36 but are likely to involve constriction in response to circulating catecholamines 32 in an 'attempt' at compensatory autotransfusion. 37 The endothelium is a key component of the vasculature. Haemorrhage will result in endothelial swelling, reducing capillary cross-sectional area by up to 20%.…”

Section: Hypovolaemic Shockmentioning

confidence: 99%

Microcirculatory dysfunction and resuscitation: why, when, and how

Moore

Dyson

Singer

et al. 2015

British Journal of Anaesthesia

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Cardiovascular resuscitation is a cornerstone of critical care practice. Experimental advances have increased our understanding of the role of the microcirculation in shock states and the development of multi-organ failure. Strategies that target the microcirculation in such conditions, while theoretically appealing, have not yet been shown to impact upon clinical outcomes. This review outlines the current understanding of microcirculatory dysfunction in septic, cardiogenic, and hypovolaemic shock and outlines available treatments and strategies with reference to their effects upon the microcirculation.

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Section: Hypovolaemic Shockmentioning

confidence: 99%

Microcirculatory dysfunction and resuscitation: why, when, and how

Moore

Dyson

Singer

et al. 2015

British Journal of Anaesthesia

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“…Many recent studies have demonstrated correlations among the diameter of the inferior vena cava (IVC) measured by ultrasound, the volemic status of the patient, and the central venous pressure (CVP). [5][6][7][8][9][10][11] This study was designed to investigate whether a correlation exists between the diameter of the IVC and laboratory findings and basic and advanced hemodynamic parameters used in the management of critically ill patients.…”

Section: Is There a Relationship Between The Diameter Of The Inferiormentioning

confidence: 99%

“…[3,4] Invasive and noninvasive parameters have been used for the diagnosis, management, and follow-up of respiratory and hemodynamic stabilization. [4][5][6] Regardless of the cause of the patient's status, the blood/ fluid volume of the patient is clearly of critical importance.…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between the diameter of the inferior vena cava and hemodynamic parameters in critically ill patients?

et al. 2015

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“…6 Therefore, arrest of bleeding and restoration of circulating blood volume with sufficient oxygen transport are 2 of the main goals in management strategies.…”

Section: Hemorrhage Due To Traumamentioning

confidence: 99%

“…30 Diminished blood volume and cardiac output lead to immediate vasoconstriction and tachycardia as a compensatory mechanism. 31 Further blood loss results in hypothermia and peripheral tissue hypoperfusion due to prolonged vasoconstriction. Hypothermia gradually derails the hemostatic system by increasing the tendency for fibrinolysis.…”

Section: The Triad Of Death and Damage Control Surgerymentioning

confidence: 99%

Permissive Hypotension in Bleeding Trauma Patients: Helpful or Not and When?

Gourgiotis

Gemenetzis

Kocher

et al. 2013

Critical Care Nurse

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T rauma remains the leading cause of mortality among persons 1 to 44 years old in the United States 1 and accounts for almost 9% of total mortality worldwide. 2 In 2008 a total of 663000 injury-related deaths occurred in Europe (6.9% of total deaths). 2 Uncontrolled bleeding and exsanguination are the leading cause of preventable death after trauma 3 and require early detection of potential bleeding sources and prompt action to minimize blood loss, restore tissue perfusion, and achieve a stable hemodynamic status. Permissive Hypotension in CNE Continuing Nursing EducationCover Severity of hemorrhage and rate of bleeding are fundamental factors in the outcomes of trauma. Intravenous administration of fluid is the basic treatment to maintain blood pressure until bleeding is controlled. The main guideline, used almost worldwide, Advanced Trauma Life Support, established by the American College of Surgeons in 1976, calls for aggressive administration of intravenous fluids, primarily crystalloid solutions. Several other guidelines, such as Prehospital Trauma Life Support, Trauma Evaluation and Management, and Advanced Trauma Operative Management, are applied according to a patient's current condition. However, the ideal strategy remains unclear. With permissive hypotension, also known as hypotensive resuscitation, fluid administration is less aggressive. The available models of permissive hypotension are based on hypotheses in hypovolemic physiology and restricted clinical trials in animals. Before these models can be used in patients, randomized, controlled clinical trials are necessary. (Critical Care Nurse. 2013;33[6]:18-25)

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Microcirculatory Responses to Hypovolemic Shock

Cited by 19 publications

References 87 publications

Microcirculatory dysfunction and resuscitation: why, when, and how

Microcirculatory dysfunction and resuscitation: why, when, and how

Is there a relationship between the diameter of the inferior vena cava and hemodynamic parameters in critically ill patients?

Permissive Hypotension in Bleeding Trauma Patients: Helpful or Not and When?

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