Microcirculatory Response to Photobiomodulation—Why Some Respond and Others Do Not: A Randomized Controlled Study

Gavish, Lilach; Hoffer, Oshrit; Rabin, Neta; Halak, Moshe; Shkilevich, Simon; Shayovitz, Yuval; Weizman, Gal; Haim, Ortal; Gavish, Benjamin; Gertz, S. David; Ovadia‐Blechman, Zehava

doi:10.1002/lsm.23225

Cited by 30 publications

(38 citation statements)

References 51 publications

(55 reference statements)

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“…Previous studies have shown that PBM induces vasodilatation in healthy volunteers [51] and treated patients [52]. In the current study, Ang-II-induced SMC contraction was terminated by PBM and was prevented by preincubation with estrogen.…”

Section: Smc Contraction and Mitochondrial Dispersionsupporting

confidence: 57%

Photobiomodulation and estrogen stabilize mitochondrial membrane potential in angiotensin–II challenged porcine aortic smooth muscle cells

Gavish

Gilon

Beeri

et al. 2020

Journal of Biophotonics

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Rupture of Abdominal aortic aneurysm (AAA) is among the 15 leading causes of death after age 65. Using high frequency ultrasound, we showed that photobiomodulation (PBM) prevents formation and progression of AAA in the angiotensin-II (Ang-II)-infused, apolipoprotein-e-deficient mouse model. In the current study we report that while challenge of porcine aortic Smooth Muscle Cells (SMCs) with Ang-II (1 μM) resulted in a marked decay in mitochondrial membrane potential (MitMP) vs non-challenged cells, treatment with PBM (continuous diode laser, 780 nm, 6.7 mW/cm 2 , 5 minutes, 2 J/cm 2) or pre-incubation with estrogen (50 nM, 1 hour) significantly attenuated this deterioration in MitMP. We also report that PBM and estrogen markedly affected porcine aortic SMC contraction and modified mitochondrial dispersion reflecting important influence on SMC function. These studies provide strong evidence of the important underlying role of mitochondria in the preventive effect of PBM on formation and progression of AAA and its reduced incidence and delayed onset in women.

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Section: Smc Contraction and Mitochondrial Dispersionsupporting

confidence: 57%

Photobiomodulation and estrogen stabilize mitochondrial membrane potential in angiotensin–II challenged porcine aortic smooth muscle cells

Gavish

Gilon

Beeri

et al. 2020

Journal of Biophotonics

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“…For clinical details, see Table 1 Table 1 patient exposure to the hospital environment in light of coronavirus disease (COVID- 19) or other potential infection in immunocompromised cancer patients. PBM was shown to be beneficial for acceleration of healing of both acute and chronic wounds [5] based on its ability to enhance the microcirculatory flow [23] and to stimulate the mitochondria energetic state even in stressed conditions [24,25]. Particularly, the PBM protocol (and the same device) used in this study was previously reported to accelerate healing of diabetic foot ulcers [15,16] and to prevent post-laminectomy scar formation when used as a preventive measure [26].…”

Section: Discussionmentioning

confidence: 99%

Supportive care of cancer patients with a self-applied photobiomodulation device: a case series

Gavish

Zadik

Raizman

2021

Support Care Cancer

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Purpose Oral mucositis (OM) and prolonged wound healing are common side-effects of cancer treatments. Photobiomodulation (PBM), previously called low-level laser, is currently part of the official guideline for OM prevention. However, all the PBM protocols relate to office-based devices, operated by professional health caregivers, requiring frequent applications. In the following case series, we present our experience with a self-applied consumer home-use PBM device for supportive care. Methods Five patients receiving cancer treatment presented at the clinic (female:male 3:2, 55-76 years old) with OM grade 3/4 (n=2), post-surgical non-healing wounds (n=3), and dermatitis (n=1). The PBM treatment (808 nm, 250 mW peak power, 15KHz, 5 J/min, ray size 4.5×1.0cm 2 ) was self-applied by the patients. The protocol included extra/intra-oral applications, over the wound bed/margins and adjacent lymph nodes. Results The treatment was found effective for resolving OM with rapid pain relief and accelerated healing in post-operative wounds and dermatitis, without reported adverse events. Patients found routine easy to follow and painless, and the protocol was easily integrated as an adjuvant treatment to standard care at the clinic or home while not requiring additional time from the staff. Conclusions Side-effects induced by cancer therapy have a detrimental effect on the patient's well-being and may delay or even prevent the patients from completing treatment regimens. PBM is already an established tool for supportive treatment in cancer patients. The advent of a self-applied personal PBM treatment with easy-to-apply protocols for a variety of side-effects makes this technology an important accessible and safe supportive care option.

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“…Moreover, a prospective, randomized, and controlled clinical trial [34] evaluated 20 healthy young participants, non-smokers, for a time of 5 min. They investigated the effects of irradiation in the wrist region, including the ulnar and radial arteries, of a cluster composed of red LEDs (wavelength in 633 nm, power density of 70 mW/cm 2 and delivered energy density of 21 J/cm 2 ) or infrared (wavelength of 830 nm, power density of 55 mW/cm 2 and delivered energy density of 16.5 J/cm 2 ).…”

Section: Hemodynamics Effectsmentioning

confidence: 99%

Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

et al. 2022

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This study verifies the acute dose response effect of photobiomodulation (PBM) by light emitting diodes (LEDs) on hemodynamic and metabolic responses in individuals with type 2 diabetes mellitus (T2DM). Thirteen participants with T2DM (age 52 ± 7 years) received PBM by a light-emitting diode array (50 GaAIAs LEDs, 850 ± 20 nm, 75 mW per diode) on the rectus and oblique abdomen, quadriceps femoris, triceps surae, and hamstring muscle areas, bilaterally, using different energy treatments (sham, 75, 150, 300, 450, and 600 Joules) in random order with a washout of at least 15 days apart. The PBM by LEDs statistically decreased plasma glucose levels (primary outcome) in 15 min after application of the 75 and 450 J irradiation protocol, reduced blood lactate levels 15 min after application of the 75, 450, and 600 J irradiation protocol, increased cardiac output (Q˙) and cardiac index (CI) in the 1st minute after application of the 75 and 300 J irradiation protocol, and reduced Q˙ and heart rate (HR) in the 15 min after application of the 300 J and 600 J irradiation protocol, respectively. For hemodynamic variables, including Q˙, total peripheral resistance (TPR), and HR, we observed that the ideal therapeutic window ranged between 75 and 300 J, while for metabolic variables, glucose and lactate, the variation was between 450 and 600 J.

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Microcirculatory Response to Photobiomodulation—Why Some Respond and Others Do Not: A Randomized Controlled Study

Cited by 30 publications

References 51 publications

Photobiomodulation and estrogen stabilize mitochondrial membrane potential in angiotensin–II challenged porcine aortic smooth muscle cells

Photobiomodulation and estrogen stabilize mitochondrial membrane potential in angiotensin–II challenged porcine aortic smooth muscle cells

Supportive care of cancer patients with a self-applied photobiomodulation device: a case series

Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

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