Microcirculatory Imaging in Cardiac Anesthesia: Ketanserin Reduces Blood Pressure But Not Perfused Capillary Density

Elbers, Paul; Ozdemir, Alaattin; Iterson, Mat van; Dongen, Eric P.A. van; İnce, Can

doi:10.1053/j.jvca.2008.09.013

Cited by 36 publications

(23 citation statements)

References 29 publications

(44 reference statements)

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“…4,13 Each parameter was determined separately for both small vessels (∅ < 20 lm, capillaries) and non-small vessels (20 lm ≤ ∅ ≤ 100 lm, mostly venules and arterioles). [13][14][15] A detailed description of these parameters and respective methods of calculation is available in Appendix S2.…”

Section: Sidestream Dark-field Imagingmentioning

confidence: 99%

Microcirculation in women with severe pre‐eclampsia and HELLP syndrome: a case–control study

Cornette

Herzog

Buijs

et al. 2013

BJOG

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Objective To compare microcirculatory perfusion in women with severe pre-eclampsia against that in healthy pregnant women, and secondly in women with severe pre-eclampsia with or without HELLP syndrome (haemolysis, elevated liver enzymes, and low platelets).Design Case-control study.Setting University Hospital Rotterdam, the Netherlands.Population Twenty-three women with severe pre-eclampsia and 23 healthy pregnant controls, matched for maternal and gestational age. Out of the 23 women with severe pre-eclampsia, ten presented with HELLP syndrome.Methods Microcirculation was analysed sublingually by a non-invasive sidestream dark-field imaging device (SDF).Main outcome measures Perfused vessel density (PVD), microcirculatory flow index (MFI), and heterogeneity index (HI) were calculated for both small vessels (∅ < 20 lm; capillaries) and non-small vessels (∅ > 20 lm; venules and arterioles).Results There were no significant differences between women with severe pre-eclampsia and healthy controls. Women with pre-eclampsia and HELLP syndrome showed a reduced PVD (P = 0.045), MFI (P = 0.008), and increased HI (P = 0.002) for small vessels, as compared with women with pre-eclampsia but without HELLP syndrome.Conclusions Sidestream dark-field is a novel, promising technique in obstetrics that permits the non-invasive evaluation of microcirculation. We did not observe major differences in sublingual microcirculatory perfusion between women with severe pre-eclampsia and healthy pregnant controls. In women with severe pre-eclampsia, the presence of HELLP syndrome is characterised by impaired capillary perfusion.Keywords Capillary, HELLP syndrome, microcirculation, microcirculatory perfusion, pre-eclampsia, sidestream dark-field imaging.Please cite this paper as: Cornette J, Herzog E, Buijs EAB, Duvekot JJ, Rizopoulos D, Hop WCJ, Tibboel D, Steegers EAP. Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case-control study.

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Section: Sidestream Dark-field Imagingmentioning

confidence: 99%

Microcirculation in women with severe pre‐eclampsia and HELLP syndrome: a case–control study

Cornette

Herzog

Buijs

et al. 2013

BJOG

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“…Administration of ketanserin in hypertensive post-CPB cardiac surgery patients effectively lowered MAP, while sublingual capillary blood flow was preserved [99]. Prostacyclin (cyclic adenosine monophosphate activator, Table 5) was initially propagated as a drug for improvement of oxygen extraction deficits, suspected to cause tissue dysoxia [100].…”

Section: Vasodilatorsmentioning

confidence: 99%

The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients

Boerma

İnce

2012

Applied Physiology in Intensive Care Medicine 2

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“…Ketanserin effectively reduced the arterial blood pressure; however, the capillary perfusion was maintained at a normal value. These findings may be attributable to increased shunting between the macrovascular and microvascular systems [67]. Hypertension during cardiac surgery was also demonstrated by Atasever and coworkers who investigated the effects of nitroglycerine therapy to treat hypertension during cardiac surgery.…”

Section: Microcirculatory Alterations During Cardiac Surgerymentioning

confidence: 80%

“…Hypertension can also occur during cardiac surgery. Elbers et al [67] investigated the effects of ketanserin, which is a serotonin and a-1 adrenoreceptor antagonist, for the treatment of high blood pressure after extracorporeal circulation following CPB. These authors demonstrated clear incoherence between the macro and microcirculation following the administration of ketanserin for high blood pressure.…”

Section: Microcirculatory Alterations During Cardiac Surgerymentioning

confidence: 99%

The response of the microcirculation to cardiac surgery

Kara

Akın

İnce

2016

Current Opinion in Anaesthesiology

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Microcirculatory Imaging in Cardiac Anesthesia: Ketanserin Reduces Blood Pressure But Not Perfused Capillary Density

Cited by 36 publications

References 29 publications

Microcirculation in women with severe pre‐eclampsia and HELLP syndrome: a case–control study

Microcirculation in women with severe pre‐eclampsia and HELLP syndrome: a case–control study

The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients

The response of the microcirculation to cardiac surgery

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