Microcirculatory dopplerography as a method to evaluate drugs endothelial protective properties in type 2 diabetic patients

Симаненкова, А. В.; Макарова, М.Н.; Васина, Л. В.; Бутомо, М. И.; Шляхто, Е. В.; Власов, Т. Д.

doi:10.24884/1682-6655-2018-17-3-120-128

Cited by 5 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Микроциркуляторный кровоток кожи у ногтевого валика пальцев рук оценивали методом высокочастотной ультразвуковой допплерографии на приборе «Минимакс-Допплер-К» (ООО СП «Минимакс», Россия, Санкт-Петербург) [13,14,22]. Метод основан на применении высокочастотных ультразвуковых колебаний для регистрации линейных и объемных скоростей кровотока в сосудах диаметром 0,3-2 мм.…”

Section: исследование микроциркуляторного кровотокаunclassified

“…Перспективной является оценка микроциркуляторного кровотока кожных покровов методом высокочастотной ультразвуковой допплерографии на приборе «Минимакс-Допплер-К» (ООО СП «Минимакс», Россия, Санкт-Петербург) [11][12][13][14][15]. Метод позволяет получить как качественные, так и количественные характеристики микроциркуляторного кровотока в покое.…”

Section: Introductionunclassified

“…Метод позволяет получить как качественные, так и количественные характеристики микроциркуляторного кровотока в покое. Кроме того, возможно проводить функциональные рефлекторные пробы [12,13,[16][17][18].…”

Section: Introductionunclassified

See 2 more Smart Citations

Early diagnosis of diabetic cardiac autonomic neuropathy by method of high-frequency ultrasonic dopplerography

Зеленина¹,

Салухов²,

Волкова³

et al. 2019

Regional blood circulation and microcirculation

View full text Add to dashboard Cite

Introduction. Diabetic neuropathy is the most wide-spread complication of diabetes mellitus and neuropathy is steadily progressing even with compensation of the underlying disease. The search of the new methods of treatment and diagnosis of neuropathy is required. Diabetic autonomic neuropathy lies in the base of early morbidity and mortality of diabetic patients.We estimated the potential of High-frequency Ultrasonic Dopplerography for diagnosis of autonomic neuropathy. Material and methods. 26 diabetic patients with sensorimotor neuropathy were examined. Microvascular blood flow of finger skin was assessed at rest as well as in functional tests: with cold impact and occlusion (cuff). Cardiac autonomic neuropathy was assessed using several cardiovascular autonomic reflex tests as a gold standard of diagnosis. Diagnostic values of microvascular blood flow test in detecting of cardiac autonomic neuropathy staging were evaluated in comparing with traditional modalities.Results. Cardiac autonomic neuropathy was found for all patients and definite/confirmed staging in 61.5 % cases. Initial parameters of microvascular blood flow velocity were significantly decreased in all patients in comparing with control (Vam= = (1.9±0.22); (1.7±0.51) and (6.7±0.51) sm/s in patients with early cardiac autonomic neuropathy, definite/confirmed staging and control subjects respectively, p<0.05). Microvascular blood flow functional testes had great informational content for diagnosis of autonomic neuropathy (sensitivity – 100 and 58 %, specify – 50 and 80 % respectively). The algorithm of diabetic patients examination was offered for early diagnosis of autonomic neuropathy staging.Conclusions. High-frequency Ultrasonic Dopplerography allowed to separate of cardiac autonomic neuropathy stages. This study is necessary to continue for revealing of all method possibilities.

show abstract

Section: исследование микроциркуляторного кровотокаunclassified

Section: Introductionunclassified

See 1 more Smart Citation

Early diagnosis of diabetic cardiac autonomic neuropathy by method of high-frequency ultrasonic dopplerography

Зеленина¹,

Салухов²,

Волкова³

et al. 2019

Regional blood circulation and microcirculation

View full text Add to dashboard Cite

show abstract

Effect of liraglutide on microcirculation in rat model with absolute insulin deficiency

Иванов

Lagutina

Saveleva

et al. 2021

Microvascular Research

View full text Add to dashboard Cite

Impairment of microvascular blood flow in patients with type 2 diabetes and cardiovascular autonomic neuropathy

et al. 2021

View full text Add to dashboard Cite

BACKGROUND: Diabetic autonomic neuropathy is the reason for early morbidity and mortality on diabetic patients. The pathology not only cardiac innervation but microvascular is presented.AIMS: We estimated the parameters of skin microvascular blood flow in accordance with cardiovascular autonomic neuropathy (CAN) staging in diabetic patients. We also assessed other risk factors of CAN in patients with diabetes.MATERIALS AND METHODS: We included 76 patients with type 2 diabetes in the study (24 patients with resent-onset diabetes and/or diabetes without microvascular complications, 26 with diabetic sensorimotor neuropathy (SMN) and 26 with SMN and previous history of diabetic foot amputation). The SMN was diagnosed on the basis of patients complaints, anamnesis and data of clinical neurological examinations. CAN was detected using several cardiovascular autonomic reflex tests (CART) as a gold standard of diagnosis: the tilt-table test, a deepbreathing and Valsalva Maneuver, handgrip test, cold-stress vasoconstriction. According to the Toronto Diabetic Neuropathy Expert Group Recommendation all patients was separated on the groups: CAN 0 (all CARTs were normal), CAN 1 (possible/early CAN — one abnormal CART was presented), CAN 2 (definite/confirmed CAN –at least two abnormal CARTs were found), CAN 3 (severe/advanced CAN — in the cases of orthostatic hypotension in addition to CARTs abnormalities). Microvascular blood flow of skin at the nail roller of fingers skin was valuated at rest as well as in functional cold test by the method of High-frequency Ultrasonic Dopplerography using the “Minimax Doppler K” device (LLC JV “Minimax”, St. Petersburg, Russia).RESULTS: CAN 1 was found in 8% diabetic patients without microvascular complications, 42 and 21% patients with SMN and diabetic foot amputations respectively. CAN 2 was diagnosed in 27% patients with SMN and 58% patients history of diabetic foot amputations. CAN 3 in 8% and 19% cases in patients with SMN and history of diabetic foot amputations respectively. The parameters of microvascular blood flow at rest were significantly decreased in patients with confirmed/severe CAN in comparison with early staging of CAN and patients without CAN (Vm=2.5±0.66 sm/sec vs. 4.4±0.54 sm/sec and 5.1±1.01 sm/sec respectively; p=0.0033). The abnormal result of cold test was detected in 94% patients with confirmed/ severe CAN and 26% patients with CAN 1.CONCLUSIONS: This investigation has demonstrated in a cohort with type 2 diabetes patients with/without SMN and with/ without history of previously foot amputations that decrease the Vm (the variable of microvascular blood flow assessed by High-frequency Ultrasonic Dopplerography) lower than 2.4 sm/sec is associated with 6.4 times increased likelihood of confirmed/severe CAN as well as positive cold test result. That the patients with positive cold test results were 28.6 times more likely have confirmed/severe CAN.

show abstract

Microcirculatory dopplerography as a method to evaluate drugs endothelial protective properties in type 2 diabetic patients

Cited by 5 publications

References 16 publications

Early diagnosis of diabetic cardiac autonomic neuropathy by method of high-frequency ultrasonic dopplerography

Early diagnosis of diabetic cardiac autonomic neuropathy by method of high-frequency ultrasonic dopplerography

Effect of liraglutide on microcirculation in rat model with absolute insulin deficiency

Impairment of microvascular blood flow in patients with type 2 diabetes and cardiovascular autonomic neuropathy

Contact Info

Product

Resources

About