Microcirculatory blood and lymph flow examination in eyelid skin by laser Doppler flowmetry

Safonova, T N; Kintyukhina, N P; Сидоров, В. В.; Gladkova, Olga Victorovna; Reyn, E S

doi:10.17116/oftalma2017133316-21

Cited by 10 publications

(2 citation statements)

References 4 publications

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“…Our previous studies substantiated the role of microcirculatory disorders in the development of chronic mixed blepharitis [9,10,11]. The parameters characterizing the perfusion and the amplitude-frequency spectrum of the blood-and-lymph flow in the eyelids were determined via laser Doppler flowmetry (LDF).…”

Section: Introductionmentioning

confidence: 74%

Analyzing The Efficacy Of Conservative Versus Surgical Treatment Of Chronic Mixed Blepharitis Via Laser Doppler Flowmetry And Interferometry

Safonova

Kintyukhina

2022

Russ Open Med J

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Objective — To analyze and compare the efficacy of conservative vs. surgical treatment of chronic mixed blepharitis via laser Doppler flowmetry and interferometry. Materials and methods — We enrolled 42 patients (the sample of 84 eyes) with chronic mixed blepharitis in the study. Laser Doppler flowmetry (LDF) was used to assess the microcirculation in the eyelid skin; interferometry was employed to evaluate the lipid layer of the tear film. Patients in the treatment group were treated by meibomian gland probing (MGP) and by artificial tears with a lipid component, introduced 4 times a day for 30 days. Subjects in the control group had their eyelid massaged in addition to administration of artificial tears. Treatment efficacy was monitored at 1 week, 1.5 months and 3 months. Results — MGP demonstrated a statistically significant positive effect, which persisted for 3 months after the procedure: specifically, the restoration of the tear film stability by increasing the thickness of its lipid layer by 0.27-0.5 μm. When comparing the interferoscopy results, an increase in the area of the lipid layer absence was detected in the control group. Analysis of LDF results showed a decrease in neurogenic and myogenic rhythms, as well as in the blood flow coefficient of variation in both groups. The lymph flow coefficient of variation remained stable in the treatment group, while it tended to decrease in the control group. Conclusion — The obtained data analysis on the basis of objective instrumental assessment of the eyelid morphofunctional state by the methods of interferoscopy and LDF suggested that conducting MGP was more effective in chronic mixed blepharitis treatment, compared with performing an eyelid massage.

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Section: Introductionmentioning

confidence: 74%

Analyzing The Efficacy Of Conservative Versus Surgical Treatment Of Chronic Mixed Blepharitis Via Laser Doppler Flowmetry And Interferometry

Safonova

Kintyukhina

2022

Russ Open Med J

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“…The variable component of the reflected signal is determined by two factors: the concentration of erythrocytes in the test sample and the speed of their movement. This method has high specificity and high sensitivity and allows determining the parameters of microcirculation and lymph flow, such as the coefficient of variation, and neurogenic and myogenic fluctuations [63,64].…”

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confidence: 99%

Pathogenetic Mechanisms Of Dry Eye Syndrome In A Novel Coronavirus Infection Caused By SARS-CoV-2

Safonova

Зайцева

2022

Russ Open Med J

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The goal of this review was to analyze current knowledge on dry eye disease pathogenesis in a novel coronavirus infection (COVID-19) caused by SARS-CoV-2. Arguments are presented in favor of several possible pathogenic mechanisms of the disease development: inflammation and/or microcirculatory disorders aggravated by exposure to electromagnetic radiation of personal computers and by use of personal protective equipment.

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Modern methods of evaluating the morphological and functional state of the eyelids in chronic blepharitis

et al. 2018

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В обзоре литературы представлены современные методы исследования морфофункционального состояния век при хроническом блефарите, разработка которых связана с продолжающимся изучением этиологии и патогенеза заболевания. Ключевые слова: блефарит, лазерная допплеровская флоуметрия, лазерная сканирующая конфокальная микроскопия, инфракрасная мейбография.

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Microcirculatory blood and lymph flow examination in eyelid skin by laser Doppler flowmetry

Abstract: The non-invasive method of LDF expands our diagnostic capabilities as it enables assessment of not only blood, but also lymph flow. The data obtained can serve as a starting point for exploring microcirculation in different age groups in the presence of different pathological processes.

Cited by 10 publications

References 4 publications

Analyzing The Efficacy Of Conservative Versus Surgical Treatment Of Chronic Mixed Blepharitis Via Laser Doppler Flowmetry And Interferometry

Analyzing The Efficacy Of Conservative Versus Surgical Treatment Of Chronic Mixed Blepharitis Via Laser Doppler Flowmetry And Interferometry

Pathogenetic Mechanisms Of Dry Eye Syndrome In A Novel Coronavirus Infection Caused By SARS-CoV-2

Modern methods of evaluating the morphological and functional state of the eyelids in chronic blepharitis

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