Microcirculatory bed of the human trigeminal nerve

Abstract

Results show that the make-up and topography of the microcirculatory bed throughout the trigeminal nerve are determined by features of the connective tissue components. Arteriolovenular anastomoses facilitate blood redistribution within the superficial layers of the trigeminal nerve, while precapillary sphincters and transepineural arterioles provide optimal regulation of blood flow in deeper layers of the nerve trunk.

Aetiology and Pathogenesis of Trigeminal Neuralgia: a Comprehensive Review

“…However, there is no evidence that supports direct relation of blood vessels pathology to TN. Smoliar [15] investigated blood vessels supplying trigeminal nerve for a large number of cadavers who died because of cardiovascular disease. Although, clear morphological changes were noted in the blood vessels but no TN was diagnosed.…”

The Trigeminal Vasculature Pathology in Patients With Neuralgia

“…Thus far, the microanatomic examination of the extratrigeminal and intratrigeminal vessels (the "vasa nervorum") was performed only in normal individuals. 4,5 Hence, the aim of our study was to undertake the electron microscopic (EM) and immunohistochemical (IHC) examination of the vasculature of the trigeminal nerve root in patients with neuralgia.…”

Quantitative13C NMR studies of metabolic compartmentation in the adult mammalian brain

“…[3][4][5][6] Second, metabolic compartmentation in the brain presents important ontogenic variations, affecting time courses, transport and metabolism of several amino acids, neurotransmitters and other metabolites in neurons and glial cells. [7][8][9][10][11] Finally, the presence and role of the blood-brain barrier, 12 and the heterogeneous distribution of neural cells, extracellular fluid and microvasculature 13 in different cerebral substructures constitute matters which cannot be easily addressed in vitro. Taken together, these circumstances make it necessary to confirm and extend the information gathered with in vitro preparations to the adult brain in vivo.…”

“…In this work we review the information provided by 13 C NMR methods on neuronal or glial metabolism and their physiological interactions in the adult mammalian brain. Relevant results obtained with in vitro systems and some pathological alterations, such as those occurring during ischemic episodes, are also covered, aiming to The relative size of the circles indicates approximately the concentration of metabolites in the small (left) or large (right) glutamate compartments.…”

“…Reproduced from the work of Berl and Clarke 30 with permission of the copyright owner provide an integrative perspective of cerebral metabolic compartmentation. Our emphasis is placed on the information obtained using 13 C multilabeled substrates, 13 C isotopomer analysis and quantitative models of metabolism. Other reviews on neuronal and glial metabolisms as viewed by 13 C NMR [20][21][22] or more classical techniques 18,19,[23][24][25] may complement the information presented here.…”