Microcirculatory Alterations in Shock States

Hamlin, Shannan K.; Parmley, C. Lee; Hanneman, Sandra K.

doi:10.1016/j.ccell.2014.04.007

Cited by 7 publications

(4 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,39 This distribution responds to the metabolic needs of each organ under normal physiological conditions and prioritizes blood flow to vital organs during pathological situations where tissue oxygenation is compromised. 1,39 The noninvasive monitoring of visceral perfusion through peripheral evaluation has gained attention due to the correlation between peripheral and visceral microcirculation. 1,5,9,17 In this study, PPG has been proposed as a potential technique to evaluate sublingual microcirculation.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The microcirculation acts as a functional distribution system which regulates blood flow and thereby oxygen supply to each individual organ 1 , 39 . This distribution responds to the metabolic needs of each organ under normal physiological conditions and prioritizes blood flow to vital organs during pathological situations where tissue oxygenation is compromised 1 , 39 . The non-invasive monitoring of visceral perfusion through peripheral evaluation has gained attention due to the correlation between peripheral and visceral microcirculation 1 , 5 , 9 , 17 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Non-invasive assessment of sublingual microcirculation using flow derived from green light PPG: evaluation and reference values

Acevedo,

Sánchez,

Londoño

et al. 2024

J. Biomed. Opt.

View full text Add to dashboard Cite

The study of sublingual microcirculation offers valuable insights into vascular changes and overcomes some limitations of peripheral microcirculation assessment. Videomicroscopy and pulse oximetry have been used to assess microcirculation, providing insights into organ perfusion beyond macrohemodynamics parameters. However, both techniques have important limitations that preclude their use in clinical practice.Aim: To address this, we propose a non-invasive approach using photoplethysmography (PPG) to assess microcirculation.Approach: Two experiments were performed on different samples of 31 subjects. First, multi-wavelength, finger PPG signals were compared before and while applying pressure on the sensor to determine if PPG signals could detect changes in peripheral microcirculation. For the second experiment, PPG signals were acquired from the ventral region of the tongue, aiming to assess the microcirculation through features calculated from the PPG signal and its first derivative. Results:In experiment 1, 13 out of 15 features extracted from green PPG signals showed significant differences (p < 0.05) before and while pressure was applied to the sensor, suggesting that green light could detect flow distortion in superficial capillaries. In experiment 2, 15 features showed potential application of PPG signal for sublingual microcirculation assessment. Conclusions:The PPG signal and its first derivative have the potential to effectively assess microcirculation when measured from the fingertip and the tongue. The assessment of sublingual microcirculation was done through the extraction of 15 features from the green PPG signal and its first derivative. Future studies are needed to standardize and gain a deeper understanding of the evaluated features.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non-invasive assessment of sublingual microcirculation using flow derived from green light PPG: evaluation and reference values

Acevedo,

Sánchez,

Londoño

et al. 2024

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

“…The information microcirculation can yield regarding the health status of a pediatric patient may be underestimated. Depending on physiological demands, microcirculation is able to compensate for alterations in vascular resistance, cardiac output, and blood pressure . It is well known that in critically ill patients microcirculation is impaired and that propofol is often used for sedation in these patients .…”

Section: Introductionmentioning

confidence: 99%

Imaging sublingual microcirculatory perfusion in pediatric patients receiving procedural sedation with propofol: A pilot study

Riedijk

Milstein

2018

Microcirculation

View full text Add to dashboard Cite

ObjectiveProcedural sedation with propofol is widely used in the pediatric population. A well‐known side effect of propofol is a decrease in peripheral vascular resistance resulting in hypotension, but little is known about the effects on microcirculation in humans. We aimed to evaluate the effects of propofol on the sublingual microcirculatory perfusion by continuous video imaging in pediatric patients undergoing procedural sedation.MethodsPatients admitted to the Pediatric Intensive Care Unit for procedural sedation were recruited. Oral microcirculation was measured employing a continuous monitoring strategy with incident dark‐field illumination imaging. Measurements were obtained before and 3 minutes after propofol induction. Total and perfused vessel densities, proportion of perfused vessels, microvascular flow index, blood vessel diameter (Øbv), and systemic hemodynamics were analyzed.ResultsContinuous measurements were achieved in seven patients. Three minutes after propofol induction mean arterial pressure decreased (P = 0.028) and total and perfused vessel densities increased by 12% (P = 0.018) and 16% (P = 0.018), respectively. MFI was unaltered and mean Øbv increased but not significantly.ConclusionsPropofol induction induces a reduction in mean arterial pressure and a rise in sublingual microvascular perfusion. The observed effects of propofol on the sublingual microcirculation may be due to a decrease in microvascular resistance.

show abstract

Actualización en sepsis y choque séptico: nuevas definiciones y evaluación clínica

Arsanios

Barragán

Garzón

et al. 2017

Acta Colombiana de Cuidado Intensivo

View full text Add to dashboard Cite

Microcirculatory Alterations in Shock States

Cited by 7 publications

References 95 publications

Non-invasive assessment of sublingual microcirculation using flow derived from green light PPG: evaluation and reference values

Non-invasive assessment of sublingual microcirculation using flow derived from green light PPG: evaluation and reference values

Imaging sublingual microcirculatory perfusion in pediatric patients receiving procedural sedation with propofol: A pilot study

Actualización en sepsis y choque séptico: nuevas definiciones y evaluación clínica

Contact Info

Product

Resources

About