Microcirculation in diabetes mellitus

Lin, Jen H.; Duffy, John L.; Roginsky, Martin S.

doi:10.1016/s0046-8177(75)80110-9

Cited by 28 publications

(20 citation statements)

References 32 publications

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“…In contrast, some reports have suggested that basement membrane thickening in microvessels at the level of true capillaries is intimately related to diabetes. [1][2][3][4][5][6] For example, Stahl et al…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] Basement membrane abnormalities such as thickness have been reported by several authors. [1][2][3][4][5][6] Anapolle et al 1 reported that biopsies from the diabetic Chinese hamster revealed an amorphous and lameller thickening of the basement membranes of blood vessels. Similarly, vascular basement lamina thickness in the gingiva of diabetic patients has also been reported.…”

Section: Introductionmentioning

confidence: 92%

“…[1][2][3][4][5][6][7][8][9][10][11] Many authors have indicated that abnormalities of the capillary walls seem to be a basic lesion in patients with diabetes mellitus. [1][2][3][4][5][6] Basement membrane abnormalities such as thickness have been reported by several authors. [1][2][3][4][5][6] Anapolle et al 1 reported that biopsies from the diabetic Chinese hamster revealed an amorphous and lameller thickening of the basement membranes of blood vessels.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, vascular basement lamina thickness in the gingiva of diabetic patients has also been reported. [2][3][4][5][6] In a review paper by Murrah,2 thickening and hyalinization of vascular walls was reported to be a 'frequent occurrence' in diabetic patients. Presumably, any type of morphologic alteration, such as a thickened capillary basement membrane, which could act as a barrier to biological functions such as oxygen diffusion, removal of metabolic waste, leukocyte migration, and diffusion of immune factors, must ultimately be involved in decreased efficiency during tissue repair and regeneration.…”

Section: Introductionmentioning

confidence: 99%

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The ultrastructure of the capillaries in the gingiva of alloxan‐induced diabetic rats

Gül

Özsoy

2003

Cell Biochemistry & Function

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The diabetic effects of alloxan (type I diabetes mellitus) were investigated in 40 Wistar albino rats (18 controls and 22 diabetics). Alloxan in sterile physiological saline was injected into animals intravenously. After the induction of diabetes with alloxan, the ultrastructure of the capillaries in the gingiva was examined by transmission electron microscopy. The thickness of the basement membranes was observed closely adherent to the endothelial cells of the capillary alloxan-diabetic rats. It was greatly thickened owing to the increase in its amorphous, granular and filamentous material with occasional scattered collagen fibres. In some sections, the capillary lumens of the diabetics were closed by epithelial cells. Loss of cytoplasmic material and hyalinization were seen in some smooth muscle cells. In addition, the mitochondrial cristae of smooth muscle cell and epithelial cells disappeared. There was endothelial integrity throughout the smooth muscle cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The ultrastructure of the capillaries in the gingiva of alloxan‐induced diabetic rats

Gül

Özsoy

2003

Cell Biochemistry & Function

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“…Importantes alterações foram observadas nos capilares intramusculares. O conceito de capilar por nós usado foi o de Lin e col. 20 , restringindo-se a vasos que consistiam exclusivamente de endotélio, lâmina basal e uma camada incompleta de pericito e cujo diâmetro interno, medido a partir da borda interna da lâmina basal, não tinha mais do que 20 micrômetros. Uma alteração constante foi a tumefação por edema das células endoteliais.…”

Section: Tabela Ingestão Média Diária De Dieta Sólida (Ds) E De Dietunclassified

Estudo morfológico no músculo gastrocnêmio de camundongos C57 BL10 submetidos à ingestão prolongada de etanol

Silva¹,

Lisboa²,

Freitas³

et al. 1996

Arq. Neuro-Psiquiatr.

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RESUMO -Os efeitos do alcoolismo crônico no músculo gastrocnêmio de camundongos bem nutridos foram estudados morfologicamente com a finalidade de se avaliar a hipótese de que o etanol exerce um papel tóxico direto sobre o músculo esquelético. Foram usados 30 camundongos C57BL10 machos, adultos jovens, divididos em dois grupos: Grupo A (controle) consistindo de 10 camundongos que beberam água e Grupo B (alcoólico) de 20 camundongos que beberam etanol a 25%. Todos os animais receberam" uma ração balanceada de laboratório e foram mantidos nesse regime ad libitum nas mesmas condições ambientais durante 48 semanas e pesados uma vez por semana. O consumo diário de dieta e a ingestão calórica foram calculados tendo os animais apresentado substancial ganho de peso, não mostrando qualquer sinal de desnutrição. Ao final do experimento os animais foram sacrificados para estudos morfológicos. Pela microscopia óptica não foram encontradas alterações. Importantes anormalidades foram observadas pela microscopia eletrônica em todos os espécimens.O retículo sarcoplasmático mostrou-se freqüentemente dilatado, resultando na formação de grandes vesículas e envolvendo as cisternas terminais com deslocamento das tríades. Áreas de estreitamento, ruptura e perda de miofibrilas ocorreram assim como zonas de completa desorganização de miofibrilas com perda do padrão estriado normal. As mitocondrias estavam em linhas gerais dentro dos limites da normalidade. Agregados tubulares peculiares vistos comumente na paralisia periódica e outras condições patológicas humanas, foram encontrados tanto no músculo dos camundongos controles como no dos alcoólicos. Os nervos intramusculares assim como as junções neuromusculares mostravam-se normais. Importantes anormalidades nos capilares musculares foram observadas, consistindo de tumefação das células endoteliais e de espessamento da lâmina basal. Difusa infiltração lipídica microvesicular foi vista no citoplasma dos hepatócitos parecendo constituir uma evidência a mais da ação tóxica do etanol sobre o organismo. Concluímos que a ingestão prolongada de etanol, representando 14,4% de calorias totais, produz no músculo gastrocnêmio de camundongos C57BL10 bem nutridos um elenco de alterações ultraestruturais que refletem um efeito tóxico direto sobre o músculo esquelético. As alterações constatadas são semelhantes àquelas descritas na miopatia alcoólica crônica humana PALAVRAS-CHAVE: ingestão prolongada de etanol, camundongos C57BL10, músculo gastrocnêmio, alterações ultraestruturais.Study of ultrastructural alterations in gastrocnemius muscle of C57 BL10 mice after prolonged ethanol ingestion ABSTRACT -The effects of chronic alcoholism on gastrocnemius muscle of well-nourished mice were morphologically studied to test the direct toxic role of ethanol on skeletal muscle. Thirty male young adult C57BL10 mice were divided in two groups: Group A (control) consisting of ten mice that drank water and Group B (alcoholic) consisting of twenty mice that drank 25% ethanol. All mice were allowed a balanced laborat...

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Abnormal Lipid Accumulation Within the Small Intestinal Mucosa of Children With Juvenile-Onset Diabetes Mellitus

Bobo¹

1977

Arch Pediatr Adolesc Med

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\s=b\ The lipid content of the proximal jejunum, as studied by light microscopy with lipid histochemical staining methods, is determined in 14 fasting children with juvenile-onset diabetes mellitus. The results show that four children had greatly increased amounts of lipid, while six others had a mildly to moderately increased amounts of lipid present. The amount of lipid present appears to correlate most closely with the quality of control of the diabetes. These results indicate either that the clearance of exogenous lipid is impaired or that there is an increased endogenous synthesis of lipid within the intestine of the diabetic child, especially in those under poor control.(Am J Dis Child 131: [962][963][964][965][966][967][968][969] 1977) Hyperlipidemia is found in "wellcontrolled" diabetic children with an incidence of 9% to 24% and is frequently found in patients with uncontrolled diabetes mellitus.13 In recent years, the small intestine has been recognized as a possible impor¬ tant source of endogenous triglycéride and cholesterol synthesis.4 A 15-year-old child with juvenileonset diabetes mellitus was referred because of recurrent abdominal pain. A fasting peroral jejunal biopsy was From the

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Microcirculation in diabetes mellitus

Cited by 28 publications

References 32 publications

The ultrastructure of the capillaries in the gingiva of alloxan‐induced diabetic rats

The ultrastructure of the capillaries in the gingiva of alloxan‐induced diabetic rats

Estudo morfológico no músculo gastrocnêmio de camundongos C57 BL10 submetidos à ingestão prolongada de etanol

Abnormal Lipid Accumulation Within the Small Intestinal Mucosa of Children With Juvenile-Onset Diabetes Mellitus

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