Microcirculation, endothelium and glycocalyx changes associated with the use of milrinone in children with septic shock
Mauricio Sarta-Mantilla,
Jaime Fernández-Sarmiento,
Lorena Acevedo
et al.
Abstract:Background
The goal of fluid resuscitation and the use of inotropes in septic shock has traditionally focused on improving blood pressure and cardiac output, without considering the microcirculatory changes. Reaching macrocirculatory goals but with persistent microcirculatory abnormalities (hemodynamic incoherence) in septic shock has been associated with greater organ dysfunction and mortality. The objective of this study was to evaluate the microcirculation (flow and capillary density) and endot… Show more
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