Microcirculation

Jackson, William F.

doi:10.1016/b978-0-12-381510-1.00089-2

Cited by 10 publications

(18 citation statements)

References 98 publications

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“…The authors did find that the VGCC blockers abolished vasomotion, establishing the efficacy of the drugs in this system. Similar results have been obtained for arterioles in hamster cremaster muscles (670), where nifedipine did not produce steady-state dilation of arterioles with substantial myogenic tone, but abolished vasomotion of these vessels. A lack of effect of nifedipine on resting diameter of cheek pouch arterioles, in vivo , was reported by Boric and colleagues (159).…”

Section: Voltage-gated Ca2+ Channelssupporting

confidence: 86%

“…That nifedipine (785, 1171) and diltiazem (185), which are both selective for L-type VGCCs, substantially inhibit myogenic tone in cremaster arterioles, in vitro , suggests that L-type channels provide a major contribution (70%–90%) in vessels studied in vitro , but the potential for significant regional-, strain-, and species-dependent differences in the contribution of different classes of VGCCs are acknowledged. In mouse cremaster muscle, in vivo , in contrast to studies of rat (599) and hamster (670), 60% of resting tone is due to L-type VGCCs, with <20% from T-type VGCCs (628). Inhibition of NO synthesis increased the contribution of T-type VGCCs to ~38% in this model.…”

Section: Voltage-gated Ca2+ Channelsmentioning

confidence: 84%

“…The presence of T-type VGCCs in addition to L-type VGCCs, as reported in rat cremaster arterioles (1460), might provide an explanation, particularly if membrane potential was slightly more hyperpolarized, in vivo . While not statistically significant, SMC membrane potential in hamster cheek pouch arterioles has been reported to be slightly more hyperpolarized in vivo (−41 ± 4 mV) than what was measured in similar vessels, in vitro (−33 ± 1 mV) (670). …”

Section: Voltage-gated Ca2+ Channelsmentioning

confidence: 88%

“…A number of studies, in vivo and in vitro , have shown that blockers of L-type VGCCs inhibit vasomotion (1, 93, 522, 523, 529, 599, 670, 998, 1010). While there are exceptions to this rule (530), the majority of published studies indicate that vasomotion depends on Ca 2+ influx through L-type VGCCs.…”

Section: Voltage-gated Ca2+ Channelsmentioning

confidence: 99%

“…In vivo , myogenic tone of second-order cremaster arterioles appears resistant to L-type Ca 2+ channel blockers (599, 670). In contrast, blockade of L-type VGCCs produces substantial dilation of these vessels when they are studied, in vitro (185).…”

Section: Bkca Channelsmentioning

confidence: 99%

See 4 more Smart Citations

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Tykocki

Boerman

Jackson

2017

Comprehensive Physiology

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272

347

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Vascular tone of resistance arteries and arterioles determines peripheral vascular resistance, contributing to the regulation of blood pressure and blood flow to, and within the body’s tissues and organs. Ion channels in the plasma membrane and endoplasmic reticulum of vascular smooth muscle cells (SMCs) in these blood vessels importantly contribute to the regulation of intracellular Ca2+ concentration, the primary determinant of SMC contractile activity and vascular tone. Ion channels provide the main source of activator Ca2+ that determines vascular tone, and strongly contribute to setting and regulating membrane potential, which, in turn, regulates the open-state-probability of voltage gated Ca2+ channels (VGCCs), the primary source of Ca2+ in resistance artery and arteriolar SMCs. Ion channel function is also modulated by vasoconstrictors and vasodilators, contributing to all aspects of the regulation of vascular tone. This review will focus on the physiology of VGCCs, voltage-gated K+ (KV) channels, large-conductance Ca2+-activated K+ (BKCa) channels, strong-inward-rectifier K+ (KIR) channels, ATP-sensitive K+ (KATP) channels, ryanodine receptors (RyRs), inositol 1,4,5-trisphosphate receptors (IP3Rs), and a variety of transient receptor potential (TRP) channels that contribute to pressure-induced myogenic tone in resistance arteries and arterioles, the modulation of the function of these ion channels by vasoconstrictors and vasodilators, their role in the functional regulation of tissue blood flow and their dysfunction in diseases such as hypertension, obesity, and diabetes.

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Section: Voltage-gated Ca2+ Channelssupporting

confidence: 86%

Section: Voltage-gated Ca2+ Channelsmentioning

confidence: 84%

Section: Voltage-gated Ca2+ Channelsmentioning

confidence: 88%

Section: Voltage-gated Ca2+ Channelsmentioning

confidence: 99%

Section: Bkca Channelsmentioning

confidence: 99%

See 3 more Smart Citations

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Tykocki

Boerman

Jackson

2017

Comprehensive Physiology

Self Cite

272

347

View full text Add to dashboard Cite

show abstract

Ion channels and the regulation of myogenic tone in peripheral arterioles

Jackson

2020

Current Topics in Membranes

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Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis

Gkontra

Norton

Żak

et al. 2018

Sci Rep

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The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding the impact of cardiovascular diseases in tissue perfusion and in developing efficient angiotherapies. Using confocal microscopy and thick tissue sections, we developed a 3D fully automated pipeline that allows to precisely reconstruct the microvasculature and to extract parameters that quantify all its major features, its relation to smooth muscle actin positive cells and capillary diffusion regions. The novel pipeline was applied in the analysis of the coronary microvasculature from healthy tissue and tissue at various stages after myocardial infarction (MI) in the pig model, whose coronary vasculature closely resembles that of human tissue. We unravelled alterations in the microvasculature, particularly structural changes and angioadaptation in the aftermath of MI. In addition, we evaluated the extracted knowledge’s potential for the prediction of pathophysiological conditions in tissue, using different classification schemes. The high accuracy achieved in this respect, demonstrates the ability of our approach not only to quantify and identify pathology-related changes of microvascular beds, but also to predict complex and dynamic microvascular patterns.

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Microcirculation

Cited by 10 publications

References 98 publications

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Ion channels and the regulation of myogenic tone in peripheral arterioles

Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis

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