Microchannel plate response to high-intensity ion bunches

Coeck, S.; Beck, M.; Delauré, B.; Golovko, V. V.; Herbane, M.; Lindroth, A.; Kopecky, S.; Козлов, В.; Kraev, I. S.; Phalet, T.; Severijns, N.

doi:10.1016/j.nima.2005.11.061

Cited by 31 publications

(19 citation statements)

References 14 publications

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“…In contrast, Tabet and coworkers observed the opposite trend for BSA: lowering the analyte concentration led to a decrease of doubly charged ions in their experiments using a conventional microchannel plate (MCP) detector [22]. The MCP suffers from very low sensitivity for high-mass ions due to their low velocity and saturation effects caused by long channel recovery times [46][47][48]. With increasing sample concentration, more channels are blocked and the saturation effect of an MCP becomes more prominent.…”

Section: Influence Of Experimental Parameters On the Charge Distributionmentioning

confidence: 99%

Compelling Advantages of Negative Ion Mode Detection in High-Mass MALDI-MS for Homomeric Protein Complexes

Mädler

Barylyuk

Erba

et al. 2011

J. Am. Soc. Mass Spectrom.

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Chemical cross-linking in combination with high-mass MALDI mass spectrometry allows for the rapid identification of interactions and determination of the complex stoichiometry of noncovalent protein-protein interactions. As the molecular weight of these complexes increases, the fraction of multiply charged species typically increases. In the case of homomeric complexes, signals from multiply charged multimers overlap with singly charged subunits. Remarkably, spectra recorded in negative ion mode show lower abundances of multiply charged species, lower background, higher reproducibility, and, thus, overall cleaner spectra compared with positive ion mode spectra. In this work, a dedicated high-mass detector was applied for measuring highmass proteins (up to 200 kDa) by negative ion mode MALDI-MS. The influences of sample preparation and instrumental parameters were carefully investigated. Relative signal integrals of multiply charged anions were relatively independent of any of the examined parameters and could thus be approximated easily for the spectra of cross-linked complexes. For example, the fraction of doubly charged anions signals overlapping with the signals of singly charged subunits could be more precisely estimated than in positive ion mode. Sinapinic acid was found to be an excellent matrix for the analysis of proteins and cross-linked protein complexes in both ion modes. Our results suggest that negative ion mode data of chemically cross-linked protein complexes are complementary to positive ion mode data and can in some cases represent the solution phase situation better than positive ion mode.

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Section: Influence Of Experimental Parameters On the Charge Distributionmentioning

confidence: 99%

Compelling Advantages of Negative Ion Mode Detection in High-Mass MALDI-MS for Homomeric Protein Complexes

Mädler

Barylyuk

Erba

et al. 2011

J. Am. Soc. Mass Spectrom.

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“…The main effort during the year 2006 was to improve the overall efficiency of the set-up [14,17] including optimization of REXTRAP for the needs of the WITCH experiment and to extend the data acquisition (DAQ) system to control more of the important parameters (sec. 5).…”

Section: Current Statusmentioning

confidence: 99%

The WITCH experiment: Acquiring the first recoil ion spectrum

Козлов

Beck

Coeck

et al. 2008

Nuclear Instruments and Methods in Physics Research Section B:

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The standard model of the electroweak interaction describes beta-decay in the well-known V-A form. Nevertheless, the most general Hamiltonian of a beta-decay includes also other possible interaction types, e.g. scalar (S) and tensor (T) contributions, which are not fully ruled out yet experimentally. The WITCH experiment aims to study a possible admixture of these exotic interaction types in nuclear beta-decay by a precise measurement of the shape of the recoil ion energy spectrum. The experimental set-up couples a double Penning trap system and a retardation spectrometer. The set-up is installed in ISOLDE/CERN and was recently shown to be fully operational. The current status of the experiment is presented together with the data acquired during the 2006 campaign, showing the first recoil ion energy spectrum obtained. The data taking procedure and corresponding data acquisition system are described in more detail. Several further technical improvements are briefly reviewed.Comment: 11 pages, 6 figures, conference proceedings EMIS 2007 (http://emis2007.ganil.fr), published also in NIM B: doi:10.1016/j.nimb.2008.05.15

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“…The WITCH experiment, first described in 2003 [19,20], has seen many technical developments and upgrades over its lifetime [27][28][29][30][31]. The first recorded recoil-ion spectrum, measured for 124 In, was reported in 2008 [23], while the first result for the β-ν correlation in 35 Ar decay was reported in 2014 [25], albeit with limited statistics.…”

Section: Introductionmentioning

confidence: 99%

First high-statistics and high-resolution recoil-ion data from the WITCH retardation spectrometer

et al. 2016

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Abstract. The first high-statistics and high-resolution data set for the integrated recoil-ion energy spectrum following the β + decay of 35 Ar has been collected with the WITCH retardation spectrometer located at CERN-ISOLDE. Over 25 million recoil-ion events were recorded on a large-area multichannel plate (MCP) detector with a time-stamp precision of 2 ns and position resolution of 0.1 mm due to the newly upgraded data acquisition based on the LPC Caen FASTER protocol. The number of recoil ions was measured for more than 15 different settings of the retardation potential, complemented by dedicated background and half-life measurements. Previously unidentified systematic effects, including an energy-dependent efficiency of the main MCP and a radiation-induced time-dependent background, have been identified and incorporated into the analysis. However, further understanding and treatment of the radiation-induced background requires additional dedicated measurements and remains the current limiting factor in extracting a betaneutrino angular correlation coefficient for 35 Ar decay using the WITCH spectrometer.

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Microchannel plate response to high-intensity ion bunches

Cited by 31 publications

References 14 publications

Compelling Advantages of Negative Ion Mode Detection in High-Mass MALDI-MS for Homomeric Protein Complexes

Compelling Advantages of Negative Ion Mode Detection in High-Mass MALDI-MS for Homomeric Protein Complexes

The WITCH experiment: Acquiring the first recoil ion spectrum

First high-statistics and high-resolution recoil-ion data from the WITCH retardation spectrometer

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