Microcapsules made of sodium alginate for the prolonged release of phenibut

Abstract

A prolonged system of the pharmaceutical substance delivery with nootropic effect was developed; it was phenibut in the form of microcapsules. The polymers used were sodium alginate as polyanion and Calcium chloride as polycation. It was realized by spraying a solution of sodium alginate in a solution of Calcium chloride, which induces the gelation. The features of the surface for the obtained microcapsules with the different ratio of nucleus/substance were determined in the work. Identification of phenibut in microcapsules was performed by IR-spectroscopy. Dependence of the microencapsulation efficiency on the concentration of film-forming material solution and the ratio of nucleus/substance was found. The process of phenibut release from microcapsules in the medium of 0.1 M solution of hydrochloric acid was investigated.