Microcalcifications in clinically normal breast: the value of high field, surface coil, Gd-DTPA-enhanced MRI

Tesoro-Tess, J. D.; Аморусо, А.; Rovini, Dario; Balzarini, Luca; Ceglia, E.; Civelli, Enrico; Trecate, Giovanna; Savio, Tommaso; Musumeci, R

doi:10.1007/bf00184955

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…Several studies have evaluated the merits of contrast‐enhanced MR imaging for the diagnosis of mammographically detected clustered microcalcifications (7, 25, 26). Westerhof et al (7) diagnosed cancer in terms of signal intensity increase, time‐signal intensity curve, and morphology of enhancing lesions.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer in dense breast: Detection with contrast-enhanced dynamic MR imaging

Kawashima

Matsui

Suzuki

et al. 2000

J. Magn. Reson. Imaging

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The purpose of this study was to identify contrast enhancement patterns of dense breast parenchyma and to investigate the ability of dynamic magnetic resonance imaging (MRI) to detect cancer in the dense breast. Thirty‐two patients with breast cancer in dense breast underwent gadolinium‐enhanced dynamic MRI. The detectability of cancer by dynamic MRI, mammography, and physical examination was compared. Two parenchymal enhancement patterns could be identified. One was increasingly multiple patchy enhancement found predominantly in the periphery (type A), and the other was faint enhancement without any nodular opacification (type B). Type A was thought to reflect severe proliferative fibrocystic change (PFC). For both patterns, the detection rate of primary cancers by dynamic MRI was found to be superior to that by other modalities. Dynamic MRI also could detect multifocal cancers, which could not be found with other modalities, although the detectability of these small cancers might be reduced in patients with severe PFC. J. Magn. Reson. Imaging 2000;11:233–243. © 2000 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Breast cancer in dense breast: Detection with contrast-enhanced dynamic MR imaging

Kawashima

Matsui

Suzuki

et al. 2000

J. Magn. Reson. Imaging

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“…Reported sensitivities for the identification of DCIS on breast MRI range from 40 to 100% [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic usefulness of segmental and linear enhancement in dynamic breast MRI

et al. 2005

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The aim of this study was the evaluation of the diagnostic usefulness of ductal or segmental enhancement in dynamic breast MRI. Segmental and ductal enhancement have been established as the breast MRI hallmarks of intraductal breast cancer (DCIS); however, the positive predictive value of this imaging finding is still unknown. In our study, we analysed the overall prevalence of a segmental or a linear enhancement pattern on breast MRI for an unselected cohort of patients. The aim was to evaluate the diagnostic usefulness of segmental or linear enhancement. Second, we asked whether biopsy was necessary also in the absence of mammographic findings suggestive of DCIS. Prospective, consecutive evaluation of 1,003 patients undergoing bilateral dynamic breast MRI. Studies were interpreted by two experienced breast radiologists. A diagnostic or screening two-view mammogram was available for all patients. Biopsy or short-term breast MRI follow-up was recommended for patients showing a segmental or a linear enhancement pattern on breast MRI. The patients' final diagnoses were established by imaging guided excisional or core biopsy or by clinical plus conventional imaging follow-up for a period of 2 years. The prevalence of segmental or linear enhancement was determined for patients with a final diagnosis of benign breast disease compared with those with a diagnosis of breast cancer. One hundred twenty patients had invasive breast cancer, 24 patients had DCIS and 859 patients had unsuspicious breast MRI or benign breast disease. A segmental or a linear enhancement pattern was found for 50/1,003 (5%) patients (17 DCIS, 33 benign breast diseases). Accordingly, the positive predictive value of segmental and linear enhancement is 34% (17/50); the specificity of this criterion is 96% (826/859). For 4/24 (17%) patients, DCIS was visible as segmental or linear enhancement on dynamic breast MRI, whereas no abnormalities were visible on the corresponding mammogram. The overall prevalence of a ductal or a segmental enhancement pattern on breast MRI is low. But this finding has a high specificity and a moderate positive predictive value for intraductal neoplastic changes. We conclude that if segmental or linear enhancement is identified on breast MRI further work-up is necessary. We recommend either direct MR-guided vacuum-assisted core biopsy or short-term follow-up breast MRI within 3 months. If ductal enhancement then persists, MR-guided biopsy should be recommended even in the absence of mammographically visible signs of DCIS.

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“…A maioria destas lesões são pequenas, de poucos milímetros e consequentemente diferentes daquelas da era pré-rastreamento mamográfico, que em geral manifestavam-se como nódulos palpáveis ou fluxo papilar (EVANS, et al,1994 (DERSHAW et al, 1989;LANYI, 1993;RUBIN,1998 -KÖBRUNNER, 1993;STELLING, 1995;OREL et al, 1996). Clemmesen" e é único para câncer mamário feminino, estando ausente no câncer mamário masculino (Clemmesen,1948apud BROEDERS:VERBEEK, 1997 , 1992;OELLINGER et al,1992;TESORO-TESS et al,1993;;GILLES et al,1993;HARMS et al, 1993;HEYWANG-KOBRUNNER et al, 1993;apud PICCOLI, 1994MELO, 1998). Por um lado, a sensibilidade próxima a 100 % da RMM com uso de agente paramagnético para identificar um câncer mamário é um avanço sobre os demais métodos por imagem disponíveis nos nossos dias, pois o método apresenta potencialidade para excluir a presença de um câncer mamário ou para demonstrá-lo quando os métodos convencionais não forem capazes de fazê-lo.…”

Section: A Ressonância Magnética Mamária E O Cdisunclassified

“…Por um lado, a sensibilidade próxima a 100 % da RMM com uso de agente paramagnético para identificar um câncer mamário é um avanço sobre os demais métodos por imagem disponíveis nos nossos dias, pois o método apresenta potencialidade para excluir a presença de um câncer mamário ou para demonstrá-lo quando os métodos convencionais não forem capazes de fazê-lo. Por outro lado, a especificidade do método tem apresentado valores flutuantes, que variam entre 37% e 97% (KAISER, 1993;TESORO-TESS et al,1993;TURKAT et al, 1993;MELO, 1998). Esta discrepância de resultados deve-se pelo menos em parte a diferenças de técnicas e de critérios diagnósticos (PICOLLI, 1994).…”

Section: A Ressonância Magnética Mamária E O Cdisunclassified

Ressonância magnética de alta resolução na avaliação do carcinoma ductal in situ mamário.

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Microcalcifications in clinically normal breast: the value of high field, surface coil, Gd-DTPA-enhanced MRI

Cited by 12 publications

References 23 publications

Breast cancer in dense breast: Detection with contrast-enhanced dynamic MR imaging

Breast cancer in dense breast: Detection with contrast-enhanced dynamic MR imaging

Diagnostic usefulness of segmental and linear enhancement in dynamic breast MRI

Ressonância magnética de alta resolução na avaliação do carcinoma ductal in situ mamário.

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