Microbotox: A prospective evaluation of dermatological improvement in patients with mild‐to‐moderate acne and erythematotelangiectatic rosacea

Abstract

There are several areas commonly treated for aesthetic purposes in the upper face (glabella, forehead, and brow), mid face (bunny lines and Crow's feet), and lower face (gummy smile, masseter, mentalis, and neck). [5][6][7][8][9][10][11][12] In addition to that, the smooth lustrous appearance of the skin due to decreased sweat and sebaceous gland activity secondary to the neuro-chemically induced bulk atrophy of the glands is an aesthetic bonus. 13 To achieve more natural and less dramatic results, clinicians started to experiment with reducing the dose and increasing the dilution to obtain optimum results in small aesthetic flaws and dermatological conditions. 8,9 There is in fact growing evidence that botulinum toxins exhibit biological effects on various human cell types with plenty of associated clinical implications: their receptors and intracellular targets are not unique for neurotransmission. 14,15 The skin, in fact, interacts with the nervous system, and there is evidence that the neurological system directly participates in cutaneous inflammation and wound healing. Botulinum Toxin type A can elicit specific biological effects in dermal fibroblasts, mast cells, sebocytes, and vascular endothelial cells

Use of botulinum toxin type A associated with nonthermal microneedling for treating erythematoustelangiectatic rosacea: A case report

“…As seen, botulinum toxin type A can be a potential tool to treat abnormal sebaceous gland activities such as erythematoustelangiectatic rosacea [9,10]. Meanwhile, at the current data, there are no studies reporting effects of nonthermal microneedling for treating rosaceaor associating it with drug delivery.…”

Treating rosacea with botulism toxin: Protocol for a systematic review and meta‐analysis

“…The basic characteristics of the included studies are presented in Table 1. Twenty‐two studies were published between 2012 and 2022 and included 720 participants, with a minimum sample size of one and a maximum of 120 9–30 . The patients included in these studies were adults, with a predominance of female patients.…”

Aesthetic considerations for treating the Asian patient: Thriving in diversity international roundtable series

“…Microtoxin is a versatile technique and has been used to improve skin quality through reducing pore size and sebum production as well as to treat medical skin conditions such as rosacea and acne. Strategically placed BoNTA along the pre‐mandibular platysma, may also reduce laxity of the lower face and improve definition of the jawline 16,22,23 …”

“…Strategically placed BoNTA along the pre-mandibular platysma, may also reduce laxity of the lower face and improve definition of the jawline. 16,22,23…”