Microbleeds in hereditary cerebral hemorrhage with amyloidosis- Dutch type

Boom, Rivka van den; Bornebroek, M.; Behloul, F.; Berg-Huysmans, Annette A. van den; Haan, Joost; Buchem, Mark A. van

doi:10.1212/01.wnl.0000156946.44593.24

Cited by 41 publications

(22 citation statements)

References 7 publications

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“…1,7 A distinct type of CAA with a genetic basis is called hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). This autosomaldominant disease is caused by a single base mutation at codon 693 of the amyloid precursor protein gene on chromosome 21 and occurs in a limited number of families in the Dutch villages of Katwijk and Scheveningen. 8 The mutation leads to extensive amyloid-␤ deposition in meningocortical arterioles.…”

mentioning

confidence: 99%

Descriptive Analysis of the Boston Criteria Applied to a Dutch-Type Cerebral Amyloid Angiopathy Population

Rooden

Grond

Boom

et al. 2009

Stroke

112

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Background and Purpose-Validation of the Boston criteria for the in vivo diagnosis of cerebral amyloid angiopathy (CAA) is challenging, because noninvasive diagnostic tests do not exist. Hereditary cerebral hemorrhage with amyloidosis-Dutch type is an accepted monogenetic model of CAA and diagnosis can be made with certainty based on DNA analysis. The aim of this study was to analyze and refine the existing Boston criteria in patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Methods-We performed T2*-weighted MRI in 27 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type to assess the presence and location of microbleeds, intracranial hemorrhages, and superficial siderosis. Using the Boston criteria, subjects were categorized as having: no hemorrhages, possible CAA, probable CAA, and hemorrhagic lesions not qualifying for CAA. The sensitivity of the Boston criteria was calculated separately using intracranial hemorrhages only and using intracranial hemorrhages and microbleeds. Results-The sensitivity of the Boston criteria for probable CAA increased from 48% to 63% when microbleeds were included. For symptomatic subjects only, the sensitivity was 100%. No hemorrhages were identified in the deep white matter, basal ganglia, thalamus, or brainstem. Superficial siderosis, observed in 6 patients, did not increase the sensitivity of the Boston criteria in our study group. Conclusions-Our data show that using T2*-weighted MRI and including microbleeds increase the sensitivity of the Boston criteria. The exclusion of hemorrhages in the deep white matter, basal ganglia, thalamus, and brainstem does not lower the sensitivity of the Boston criteria.

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mentioning

confidence: 99%

Descriptive Analysis of the Boston Criteria Applied to a Dutch-Type Cerebral Amyloid Angiopathy Population

Rooden

Grond

Boom

et al. 2009

Stroke

112

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show abstract

“…2,3,[16][17][18][19][20][21] The remaining 3 presented continuous data (i.e., mean number of BMBs per genotype) or purely qualitative statements about the association between APOE and BMBs. [22][23][24] Study characteristics. Study populations comprised either healthy people from the general population (3 studies, 5,977 participants) or those with neurologic (mainly cerebrovascular) conditions (7 studies, 1,374 participants).…”

Section: Resultsmentioning

confidence: 99%

“…The studies with data unavailable or unsuitable for our meta-analyses were much smaller in size than the included studies and performed less well against our methodologic quality indicators (table 2). [22][23][24] The largest study was of high quality and contributed over half of the participants included in the meta-analyses. 3,21 Where both crude and adjusted ORs were available, they were similar.…”

Section: Resultsmentioning

confidence: 99%

10 Genetic associations with brain microbleeds: systematic review and meta-analyses

Sudlow

Maxwell

Jackson

et al. 2011

Journal of Neurology, Neurosurgery & Psychiatry

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Objective: We performed a systematic review and meta-analyses to assess the evidence for genetic associations with brain microbleeds (BMBs). Methods:We sought all published studies of the association between any genetic polymorphism and BMBs studied in a total of Ͼ100 people. We critically appraised studies, and calculated pooled odds ratios (ORs) using the generic inverse variance fixed effects method. We used I 2 and 2 statistics to assess heterogeneity, and fail-safe N estimates to assess the robustness of our results. Results:Only the APOE ⑀2/3/4 polymorphism had been studied in Ͼ100 people (10 studies, Conclusions:Given the known associations of APOE alleles with lobar intracerebral hemorrhage and cerebral amyloid angiopathy, these findings support the concept that strictly lobar BMBs may be an imaging biomarker of cerebral amyloid angiopathy. Neurology ® 2011;77:158-167 GLOSSARY BMB ϭ brain microbleed; CAA ϭ cerebral amyloid angiopathy; CI ϭ confidence interval; GRE ϭ gradient-recalled echo; HWE ϭ Hardy-Weinberg equilibrium; ICH ϭ intracerebral hemorrhage; OR ϭ odds ratio.Brain microbleeds (BMBs) are minute deposits of blood products, seen as focal areas of signal loss typically Ͻ10 mm in diameter on haem-sensitive T2*-weighted gradient-recalled echo (GRE) MRI sequences. BMBs occur in 5% to 38% of apparently healthy people, increasing in frequency with age, hypertension, and smoking.

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“…Así, se reporta una incidencia en individuos neurológicamente asintomáticos de un 6,4%, la mayoría hipertensos, mayores de 65 años, con MH ubicadas principalmente en ganglios basales y tálamo, asociadas a lesiones isquémicas lacunares antiguas y leucoariosis (27) ; un 10% en pacientes con infarto al miocardio (28) ; un 21% a 47% en pacientes con (ECV) isquémico no seleccionado (26,29) ; un 46% a 62% en pacientes con infarto lacunar agudo, que aumenta a un 68% cuando son múltiples (29,31) y un 50% a 80% en pacientes con HE primaria (32)(33)(34)(35)(36) . Recientemente se ha descrito la presencia de MH en la angiopatía cerebral B-amiloidea, ubicadas en la región córtico-subcortical, que se asocian fuertemente a HE e incluso pueden precederla (37)(38)(39)(40) . Varios estudios relacionan las MH con complicaciones hemorrágicas encefálicas.…”

Section: Discussionunclassified

Hematoma talámico bilateral simultáneo: Reporte de dos casos y revisión de la literatura

2006

Rev. chil. neuro-psiquiatr.

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Microbleeds in hereditary cerebral hemorrhage with amyloidosis- Dutch type

Cited by 41 publications

References 7 publications

Descriptive Analysis of the Boston Criteria Applied to a Dutch-Type Cerebral Amyloid Angiopathy Population

Descriptive Analysis of the Boston Criteria Applied to a Dutch-Type Cerebral Amyloid Angiopathy Population

10 Genetic associations with brain microbleeds: systematic review and meta-analyses

Hematoma talámico bilateral simultáneo: Reporte de dos casos y revisión de la literatura

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