Microbiote intestinal, la clé pour une meilleure alimentation ?

Veiga, Patrick; Tap, Julien; Derrien, Muriel

doi:10.1051/medsci/20163211016

Cited by 1 publication

(1 citation statement)

References 39 publications

(46 reference statements)

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“…Modern life is intimately linked to changes in eating habits, which in turn impact the composition of the intestinal microbiota. Indeed, human evolution has been accompanied by incessant changes in lifestyle (including diet) [136][137][138]. Thus, humans evolved from being nomadic hunter-gatherers to a sedentary civilization practicing a new lifestyle based on agriculture and animal husbandry.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

et al. 2021

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The intestinal epithelium serves as an effective barrier against the external environment, hampering the passage of potentially harmful substances (such as pathogenic microbes) that could trigger an exacerbated host immune response. The integrity of this barrier is thus essential for the maintenance of proper intestinal homeostasis and efficient protective reactions against chemical and microbial challenges. The principal consequence of intestinal barrier defects is an increase in intestinal permeability, which leads to an increased influx of luminal stressors, such as pathogens, toxins, and allergens, which in turn trigger inflammation and immune response. The fine and fragile balance of intestinal homeostasis can be altered by multiple factors that regulate barrier function, many of which are poorly understood. This review will address the role of gut microbiota as well as food supplements (such as probiotics, prebiotics, and synbiotics) in modulating gut health and regulating intestinal barrier function. In particular, we will focus on three human pathologies: inflammatory bowel disease, irritable bowel syndrome, and food allergy.

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Section: Discussionmentioning

confidence: 99%