Microbiota profiling in esophageal diseases: Novel insights into molecular staining and clinical outcomes

Barchi, Alberto; Massimino, Luca; Mandarino, Francesco Vito; Vespa, Edoardo; Sinagra, Emanuele; Almolla, Omar; Passaretti, Sandro; Fasulo, Ernesto; Parigi, Tommaso Lorenzo; Cagliani, Stefania; Spanò, Salvatore; Ungaro, Federica; Danese, Silvio

doi:10.1016/j.csbj.2023.12.026

Cited by 4 publications

(2 citation statements)

References 131 publications

(216 reference statements)

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“…Results from this study provide further support to the efficacy of using probiotic-based supplements in improving GERD symptoms through the re-establishment of the balance and composition of the oesophageal, gastric, and intestinal microbiome [ 39 ]. Indeed, the results could be related to the combined effect of Lactobacillus strain [ 20 , 21 , 22 ] and bioactive peptides obtained from soy proteins fermentation [ 24 , 25 ] used, through the amelioration of the Gram+/Gram− ratio, the mucosal function, and the immune response [ 21 ], and pepsinogen secretion [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 71%

Efficacy of a Food Supplement Containing Lactobacillus acidophilus LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease

Tursi,

Benedetto,

Spina

et al. 2024

Nutrients

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Dietary interventions represent an interesting alternative to pharmacological treatments for improving the quality of life (QoL) of subjects suffering from gastroesophageal reflux disease (GERD). This randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of a food supplement (FS) containing a probiotic strain, bioactive peptides, and vitamins in relieving heartburn/dyspeptic symptoms in subjects with mild-to-moderate GERD. Fifty-six adult participants were randomly assigned to receive the placebo or the active FS for 28 days. Subjects were asked to record daily the frequency and intensity of heartburn episodes and the intake of over- the-counter (OTC) medications. GERD-QoL and self-assessment questionnaires were also completed every two weeks and at the end of the treatment, respectively. FS was effective in achieving a progressive and significant reduction of heartburn frequency and severity, with an intergroup significant difference at the end of the treatment period. FS group also reported a reduction in the OTC medication intake, whereas placebo administration did not modify the OTC intake. Results from the QoL and self-assessment questionnaires showed that FS administration achieved a progressive and statistically significant intragroup and intergroup improvement in the QoL score and a higher positive response with respect to the placebo treatment.

show abstract

Section: Discussionmentioning

confidence: 71%

Efficacy of a Food Supplement Containing Lactobacillus acidophilus LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease

Tursi,

Benedetto,

Spina

et al. 2024

Nutrients

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“…Additionally, the role of the microbiota in EoE pathogenesis has been explored [28]. The complex interplay between mucosal-associated microbiota has been studied in relation to several GI diseases, uncovering intriguing correlations [46][47][48][49]. A recent meta-analysis conducted by Massimino et al has unveiled an underlying dysbiosis, characterized by a shift towards an oral-shaped Gram-negative predominant environment, marking the onset of EoE [50].…”

Section: Epidemiology Physiopathology and Clinical Manifestationsmentioning

confidence: 99%

The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders—A Comprehensive Review

Barchi,

Vespa,

Passaretti

et al. 2024

Diagnostics

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Eosinophilic Gastrointestinal Disorders (EGIDs) are a group of conditions characterized by abnormal eosinophil accumulation in the gastrointestinal tract. Among these EGIDs, Eosinophilic Esophagitis (EoE) is the most well documented, while less is known about Eosinophilic Gastritis (EoG), Eosinophilic Enteritis (EoN), and Eosinophilic Colitis (EoC). The role of endoscopy in EGIDs is pivotal, with applications in diagnosis, disease monitoring, and therapeutic intervention. In EoE, the endoscopic reference score (EREFS) has been shown to be accurate in raising diagnostic suspicion and effective in monitoring therapeutic responses. Additionally, endoscopic dilation is the first-line treatment for esophageal strictures. For EoG and EoN, while the literature is more limited, common endoscopic findings include erythema, nodules, and ulcerations. Histology remains the gold standard for diagnosing EGIDs, as it quantifies eosinophilic infiltration. In recent years, there have been significant advancements in the histological understanding of EoE, leading to the development of diagnostic scores and the identification of specific microscopic features associated with the disease. However, for EoG, EoN, and EoC, precise eosinophil count thresholds for diagnosis have not yet been established. This review aims to elucidate the role of endoscopy and histology in the diagnosis and management of the three main EGIDs and to analyze their strengths and limitations, their interconnection, and future research directions.

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From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis

Barchi,

Mandarino,

Yacoub

et al. 2024

Biomolecules

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Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. EoE shares a common pathogenetic mechanism with other chronic disorders pertaining to the type 2 inflammatory spectrum, such as atopic dermatitis (AD), allergic rhinitis (AR), asthma, and chronic rhinosinusitis with nasal polyps (CRSwNP). The recent advancements in EoE pathogenesis understanding have unveiled new molecular targets implied within the “atopic march” picture as well as specific to EoE. These discoveries have led to the clinical evaluation of several novel drugs (monoclonal antibodies and immune modulators), specifically aimed at the modulation of Th2 inflammation. In this comprehensive review, we have focused on the subtle mechanisms of type 2 inflammatory disorders, highlighting the similarities and differences with EoE, taking a deeper look into the evolving field of biologic therapies, already approved or under current investigation.

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Microbiota profiling in esophageal diseases: Novel insights into molecular staining and clinical outcomes

Cited by 4 publications

References 131 publications

Efficacy of a Food Supplement Containing Lactobacillus acidophilus LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease

Efficacy of a Food Supplement Containing Lactobacillus acidophilus LA14, Peptides, and a Multivitamin Complex in Improving Gastroesophageal Reflux Disease-Related Outcomes and Quality of Life of Subjects Showing Mild-to-Moderate Gastroesophageal Reflux Disease

The Dual Lens of Endoscopy and Histology in the Diagnosis and Management of Eosinophilic Gastrointestinal Disorders—A Comprehensive Review

From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis

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