Microbiota-Pain Association; Recent Discoveries and Research Progress

Alizadeh, Naser; Naderi, Ghazal; Kahrizi, Mohammad Saeed; Haghgouei, Tannaz; Mobed, Ahmad; Shah-Abadi, Mehran Ebrahimi

doi:10.1007/s00284-022-03124-9

Cited by 8 publications

(6 citation statements)

References 95 publications

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“…Temporary changes in the composition of the GI microbiota during a critical developmental period have long-term effects on nociceptive pathways, and the gut microbiome in particular in male newborns but not adult rats (O'Mahony et al, 2014). Histamine is emerging as a relevant mediator of visceral hyperalgesia (De Palma et al, 2022), and multiple studies investigating the highly complex processes are well summarised in several recent review articles (Alizadeh et al, 2022;Ustianowska et al, 2022;Mayer et al, 2023;Pujo et al, 2023;Sarnoff et al, 2023;Shaikh et al, 2023;Shin and Kashyap, 2023). 9 Sex-specific differences…”

Section: Gut Microbiome and Pain Disordersmentioning

confidence: 99%

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

Riehl,

Fürst,

Kress

et al. 2024

Front. Neurosci.

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Increasing evidence links the gut microbiome and the nervous system in health and disease. This narrative review discusses current views on the interaction between the gut microbiota, the intestinal epithelium, and the brain, and provides an overview of the communication routes and signals of the bidirectional interactions between gut microbiota and the brain, including circulatory, immunological, neuroanatomical, and neuroendocrine pathways. Similarities and differences in healthy gut microbiota in humans and mice exist that are relevant for the translational gap between non-human model systems and patients. There is an increasing spectrum of metabolites and neurotransmitters that are released and/or modulated by the gut microbiota in both homeostatic and pathological conditions. Dysbiotic disruptions occur as consequences of critical illnesses such as cancer, cardiovascular and chronic kidney disease but also neurological, mental, and pain disorders, as well as ischemic and traumatic brain injury. Changes in the gut microbiota (dysbiosis) and a concomitant imbalance in the release of mediators may be cause or consequence of diseases of the central nervous system and are increasingly emerging as critical links to the disruption of healthy physiological function, alterations in nutrition intake, exposure to hypoxic conditions and others, observed in brain disorders. Despite the generally accepted importance of the gut microbiome, the bidirectional communication routes between brain and gut are not fully understood. Elucidating these routes and signaling pathways in more detail offers novel mechanistic insight into the pathophysiology and multifaceted aspects of brain disorders.

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Section: Gut Microbiome and Pain Disordersmentioning

confidence: 99%

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

Riehl,

Fürst,

Kress

et al. 2024

Front. Neurosci.

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“…On the other hand, the gut bidirectionally communicates with the central nervous system via immunological, hormonal, and neural pathways, the complex interaction being named the gut-brain axis [11]. Today, when everyone recognizes the microbiome as an integral part of the gut, both in the mucosa and the lumen, and as influencing the bidirectional signaling pathways between the central nervous system and the gut, this gut-brain axis is called the microbiome-gut-brain axis [12][13][14][15][16].…”

Section: Pain and The Gut Microbiomementioning

confidence: 99%

“…Visceral or splanchnic pain results from the activation of nociceptors of the thoracic, pelvic, or abdominal organs. Splanchnic organs are highly sensitive to distension, ischemia, and inflammation, but are relatively insensitive to other stimuli that normally evoke pain, such as cutting or burning [16,38]. Thus, the colorectal distension model-although scheduled for inflammatory bowel disease or irritable bowel syndrome simulation-could be considered a model characterized by visceral pain associated with altered transit time, as occurs in the postoperative situation of paralytic ileus, before the gut starts to move again.…”

Section: Experimental Studiesmentioning

confidence: 99%

Probiotics in Postoperative Pain Management

Fyntanidou,

Amaniti,

Soulioti

et al. 2023

JPM

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Postoperative pain is the unpleasant sensory and emotional experience after surgery, its origin being both the inflammatory reaction induced by the surgical trauma on the abdominal wall and the splanchnic pain induced by the activation of nociceptors of the viscera, which are highly sensitive to distension, ischemia, and inflammation. Nowadays, it is well recognized that there is a close relationship between the gut microbiome and pain perception, and that microbiome is highly affected by both anesthesia and surgical manipulation. Thus, efforts to restore the disturbed microbiome via supplementation with beneficial bacteria, namely probiotics, seem to be effective. In this article, the knowledge gained mainly from experimental research on this topic is analyzed, the concluding message being that each probiotic strain works in its own way towards pain relief.

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“…The gut microbiota has garnered significant attention as a potential environmental factor that may impact the health status of a host. There is mounting evidence linking the gut microbiota to various chronic pain conditions in humans, such as inflammatory pain and neuropathic pain (Alizadeh et al 2022 ; Guo et al 2019 ). However, it is currently unknown how the gut microbiota plays a role in PHN patients.…”

Section: Introductionmentioning

confidence: 99%

Alterations of the gut microbiota in patients with postherpetic neuralgia

Jiao,

Cao,

Zhang

et al. 2023

AMB Expr

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Postherpetic neuralgia (PHN) is a prevalent, intricate, and intractable form of neuropathic pain. The available evidence indicates that alterations in the gut microbiota are significant environmental determinants in the development of chronic neuropathic pain. Nevertheless, the correlation between the gut microbiota and PHN remains elusive. A cross-sectional study was performed on a cohort of 27 patients diagnosed with PHN and 27 matched healthy controls. Fecal samples were collected and subjected to microbiota analysis using 16S ribosomal RNA gene sequencing. Comparable levels of bacterial richness and diversity were observed in the gut microbiota of PHN patients and healthy controls. A significant difference was observed in 37 genera between the two groups. Furthermore, the LEfSe method revealed that the abundance levels of Escherichia-Shigella, Streptococcus, Ligilactobacillus, and Clostridia_UCG-014_unclassified were elevated in PHN patients, while Eubacterium_hallii_group, Butyricicoccus, Tyzzerella, Dorea, Parasutterella, Romboutsia, Megamonas, and Agathobacter genera were reduced in comparison to healthy controls. Significantly, the discriminant model utilizing the predominant microbiota exhibited efficacy in distinguishing PHN patients from healthy controls, with an area under the curve value of 0.824. Moreover, Spearman correlation analysis demonstrated noteworthy correlations between various gut microbiota and clinical symptoms, including disease course, anxiety state, sleep quality, heat pain, pain intensity, and itching intensity. Gut microbiota dysbiosis exists in PHN patients, microbiome differences could be used to distinguish PHN patients from normal healthy individuals with high sensitivity and specificity, and altered gut microbiota are related to clinical manifestations, suggesting potentially novel prevention and therapeutic directions of PHN.

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Microbiota-Pain Association; Recent Discoveries and Research Progress

Cited by 8 publications

References 95 publications

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

Probiotics in Postoperative Pain Management

Alterations of the gut microbiota in patients with postherpetic neuralgia

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