Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle

Azzimonti, Barbara; Ballacchino, Chiara; Zanetta, Paola; Cucci, Marie Angèle; Monge, Chiara; Grattarola, Margherita; Dianzani, Chiara; Barrera, Giuseppina; Pizzimenti, Stefania

doi:10.3390/antiox12030546

Cited by 13 publications

(8 citation statements)

References 189 publications

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“…Skin cancer, including BCC, is often linked to oxidation of the skin, mediated by UV exposure [13][14][15]. Interestingly, while depletion of C. acnes was more noticeable in the biopsy lesions, the skin swabs showed greater decline of roxP (a strong antioxidant unique for C. acnes) gene expression in BCC.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Perturbed Skin Microbiome in Basal Cell Carcinoma

Keum,

Sul,

Kim

et al. 2023

Preprint

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Increasing amount of evidence links dysbiosis to various human disease states, which includes cancer. This study aimed to examine the skin microbiome in basal cell carcinoma (BCC) and compare it with that of the healthy-looking skin within the same individual to identify skin cancer-associated changes in the skin microbiome. We performed high resolution analysis of full-length 16S rRNA amplicons, and utilized both skin swabs and biopsy samples which were analyzed separately and altogether. Sequencing of the total 56 samples identified the most abundant species as C. acnes which was significantly more prevalent in Control (biopsy dataset; combined dataset) than in BCC. Random Forest analysis identified 24 microbes that discriminated BCC with C. acnes being the most discriminative taxa (G = 2.08). Using PICRUSt2, we observed diminishment of Vitamin B6 metabolism in the BCC lesions. Absolute quantification of Radical oxygenase of Propionibacterium acnes (roxP, a strong antioxidant unique for C. acnes ) gene by qPCR revealed a significant drop in the relative copy number of roxP to the 16S rRNA gene in the BCC lesion (swab samples, P < 0.05). Our study identified transitional microbial dysbiosis form healthy skin to BCC and support further investigation of how these microbes may influence skin cancer progression.

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Section: Discussionmentioning

confidence: 99%

Characterization of a Perturbed Skin Microbiome in Basal Cell Carcinoma

Keum,

Sul,

Kim

et al. 2023

Preprint

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“…Oxidative stress [ 37 , 38 ] and microbiome parameters [ 39 ], although very important, would not be assessed, as it is very difficult and not practical to predict those parameters by assessing patients age, gender, comorbidities, and lifestyle choices.…”

Section: Methodsmentioning

confidence: 99%

Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters

Karampinis,

Papadopoulou,

Chaidaki

et al. 2024

Vaccines

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The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model of exposome research. This scenario explores the fine balance between protective and exacerbating factors, providing insights into the complex relationship between environmental exposure and psoriasis immunopathogenesis when a trigger appears, such as that of the hyperinflammatory state induced by the COVID-19 vaccine. Analyzing interactions between vaccine-induced phenomena and exposome parameters may provide clinically relevant information important for personalized medicine decision-making. We performed a literature review seeking patients with plaque psoriasis flares or new onset or change in plaque psoriasis into another psoriasis subtype, such as pustular or erythrodermic flare, focusing on the inner and external exposome traits of patients. We identified 71 patients with plaque psoriasis flares, 12 patients with new-onset psoriasis, and 17 with plaque psoriasis subtype change, and assessed the COVID-19 vaccine-induced plaque psoriasis in terms of clinical presentation, post-vaccination flare period and treatment status, as well as inner exposome parameters (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) and external parameters (UV, infectomics). Novel data on psoriasis flares following COVID-19 vaccination are primarily obtained by combining exposome and vaccine-triggered episode features and characteristics and comparing them with similar psoriasis flares unrelated to COVID-19 vaccination.

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“…Consequently, these effects negatively impact skin inflammation. The overproduction of ROS plays a crucial role in the pathogenesis of AD, psoriasis and vitiligo 30 . In this context, antioxidant and anti‐inflammatory properties become essential parameters to be evaluated and incorporated into therapeutic textiles.…”

Section: Symptomsmentioning

confidence: 99%

Therapeutic textiles: A promising approach for human skin dysbiosis?

de Oliveira,

Tavaria

2024

Experimental Dermatology

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The close interaction between skin and clothing has become an attractive cornerstone for the development of therapeutic textiles able to alleviate skin disorders, namely those correlated to microbiota dysregulation. Skin microbiota imbalance is known in several skin diseases, including atopic dermatitis (AD), psoriasis, seborrheic dermatitis, rosacea, acne and hidradenitis suppurative (HS). Such microbiota dysregulation is usually correlated with inflammation, discomfort and pruritus. Although conventional treatments, that is, the administration of steroids and antibiotics, have shown some efficacy in treating and alleviating these symptoms, there are still disadvantages that need to be overcome. These include their long‐term usage with side effects negatively impacting resident microbiota members, antibiotic resistance and the elevated rate of recurrence. Remarkably, therapeutic textiles as a non‐pharmacological measure have emerged as a promising strategy to treat, alleviate the symptoms and control the severity of many skin diseases. This systematic review showcases for the first time the effects of therapeutic textiles on patients with skin dysbiosis, focusing on efficacy, safety, adverse effects and antimicrobial, antioxidant and anti‐inflammatory properties. The main inclusion criteria were clinical trials performed in patients with skin dysbiosis who received treatment involving the use of therapeutic textiles. Although there are promising outcomes regarding clinical parameters, safety and adverse effects, there is still a lack of information about the impact of therapeutic textiles on the skin microbiota of such patients. Intensive investigation and corroboration with clinical trials are needed to strengthen, define and drive the real benefit and the ideal biomedical application of therapeutic textiles.

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Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle

Cited by 13 publications

References 189 publications

Characterization of a Perturbed Skin Microbiome in Basal Cell Carcinoma

Characterization of a Perturbed Skin Microbiome in Basal Cell Carcinoma

Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters

Therapeutic textiles: A promising approach for human skin dysbiosis?

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