Microbiota intestinal humana y dieta

Padrón-Pereira, Carlos Alberto

doi:10.18779/cyt.v12i1.176

Cited by 2 publications

(2 citation statements)

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“…Pathogenic species may stimulate in ammation by suppressing in ammatory or epithelial cell autophagy (62). Ezakiella species are normally associated with the consumption of high carbohydrate diet (75,76). Navarro-López et al (2022) found the association of Ezakiella with Relapse Remitting Multiple Sclerosis (RRMS) and declared it as a risk factor in RRMS patients (55).…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium avium subspecies paratuberculosis (MAP) infection, and its impact on gut microbiome of individuals with Multiple Sclerosis

Ashraf,

Dikarlo,

Masia

et al. 2023

Preprint

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Background There is a growing body of evidence suggesting the role of gut microbiome in the aetiology of Multiple sclerosis (MS) with the development and progression of the disease as a multifactorial interaction between the gut, the brain, and the immune system. At the same time there is also existing evidence to link Mycobacterium avium subspecies paratuberculosis infections (MAP) and the development of MS. Whilst perturbations of the gut microbiome in patients with MS are well described in the literature, nothing is known about the gut microbiome perturbations in MAP infected MS patients. In the present study, using 16S rRNA amplification, we characterize the compositional and functional differences of the gut microbiome between MS patients with MAP (MAP+) and without (MAP-) infection and compare the results with a healthy cohort to understand the gut microbiome dynamics. Results Based on diversity analyses, there were notable differences between HC, MAP-, and MAP + profiles. Fitting neutral modelling on core microbiome, we have found taxa selected by the hosts, and those that were based on dispersal limitation. Core phyla shared between MAP + and MAP- belonged to Actinobacteria, Bacteroidata, Verrucomicrobiota, Firmicutes, with additional Desulfobacterota, and Proteobacteria observed in MAP + only. Using a Quasi Conditional Association Test, Archaea were over represented in MS samples, particularly in MAP+. Using contingency analyses, we are able to identify discriminatory patterns between MAP statuses in the context of anthropometric and sociodemographic patterns. Finally, an advanced mediation analysis then consolidates confounders, treatment groups, microbiome, and the outcome parameters (including disease duration). This highlighted certain species i.e., Sutterella, Akkermmansia, Bacteriodes, Gastranaerophilales, Alistipes, Balutia, Faecalibacterium, Lachnospiraceae, Anaerostipes, Ruminococcaceae, Eggerthellaceae and Clostridia-UCG-014 having mediatory effect considering disease duration as an outcome and MAP as a treatment group. Conclusions Overall, we found that there were profound differences in the composition and function of the gut microbiome between MAP + and MAP- MS patients, with the difference in taxonomic structure being greater than the functional difference. Our analysis indicates that the gut microbiome may be an important target for dietary and lifestyle intervention in MS patients with and without MAP infection.

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Section: Discussionmentioning

confidence: 99%

Mycobacterium avium subspecies paratuberculosis (MAP) infection, and its impact on gut microbiome of individuals with Multiple Sclerosis

Ashraf,

Dikarlo,

Masia

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…These dietary habits may correlate with disease severity and comorbidities, since the consumption of saturated fats, sugars, beef, and alcohol interfere with the systemic inflammatory status, whereas, dietary fiber intake may contribute to the suppression of certain inflammatory pathways and the induction of regulatory T-cells. 12 , 13 , 14 …”

Section: Discussionmentioning

confidence: 99%