Microbiota, Immune System and Colorectal Cancer

Харченко, Евгений Петрович; Соловьев, Я. А.

doi:10.17650/2220-3478-2017-7-4-11-19

Cited by 2 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Также к числу онкогенных бактерий относят сульфидогенные бактерии [18], сальмонеллы и другие патогенные микроорганизмы, способствующие развитию воспаления в толстой кишке [ 19].…”

Section: Introductionunclassified

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Ermolenko,

Alyokhina,

Kashchenko

et al. 2024

jour

View full text Add to dashboard Cite

Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of the study was to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and E. hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. The use of autoprobiotics did not cause side effects and led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The features of the intestinal microbiome in patients with CRC were revealed, which are fundamentally different from those of other authors by an increase in alpha- biodiversity, lactobacilli, bifidobacteria, Bacteroides thetaiotaomicron and its additional differences associated with the absence of non-pathogenic enterococci: a greater amount of Parvimonas micra, a smaller amount of Akkermansia spp., an increase in the content of Klebsiella sp., Fusobacterium nucleatum and Clostridium perfringens. The use of autoprobiotics led to the elimination of P. micra, a decrease in C. perfringens, which led to the normalization of the microbiota in most patients. The effectiveness of autoprobiotics in the treatment of CRC has been proven, which, apparently, is associated with a change in the composition of intestinal microbiocenosis.

show abstract

Section: Introductionunclassified

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Ermolenko,

Alyokhina,

Kashchenko

et al. 2024

jour

View full text Add to dashboard Cite

show abstract

Microbiocenosis of adenocarcinoma tissue in colon cancer patients with different preoperative preparation

Simonenko,

Zlatnik,

Panova

et al. 2023

jour

View full text Add to dashboard Cite

Purpose of the study. To assess the effect of inclusion of lactoglobulin in complex preoperative preparation of colon cancer patients on their tumor and resection line tissue microbiota.Materials and methods. 40 patients with colon cancer stages II–III, in whom the operation was the first stage of treatment, during standard preoperative preparation, were injected with a preparation of antibodies against opportunistic intestinal microorganisms obtained from colostrum of immunized cows, 2 g twice a day orally before surgery for 3 days (total dose of 12 g) (main group); 40 patients received standard antibiotic prophylaxis (control group). The quantitative composition of the microbiota was determined in the samples of the removed tumor and tissue of the resection line.Results. The total microbial contamination of the tumor was 9.2 times lower in the main group relative to the control group; the frequency of E.coli and Clostridiae excretion was also statistically significantly lower (p = 0.004 and 0.03, respectively). In the tumors of patients of the main group out of twelve studied representatives of microorganisms, the number of six was statistically significantly lower than in control group, and three of those found in the control group were not detected. Since they were potentially pathogenic (Pseudomonas aeruginosa, Staphylococcus aureus, fungi of the Candida spp.), the microbial composition of the tumor of patients in the main group can be considered more favorable than the control group. Similar differences were noted in non-t umor intestinal tissue, in which the content of Enterobacter spp, Streptococcus, Clostridiae, Peptostreptococci was statistically significantly lower than in the control group.Conclusion. Thus oral administration of colostrum antibodies caused positive changes in tumor and colon tissue microbiota. We suggest the application of lactoglobulin to be useful for surgical treatment of such patients taking into account the possible impact of microbiota in patients’ response to chemo- and immunotherapy.

show abstract

Microbiota, Immune System and Colorectal Cancer

Cited by 2 publications

References 46 publications

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Microbiocenosis of adenocarcinoma tissue in colon cancer patients with different preoperative preparation

Contact Info

Product

Resources

About