Microbiota and Food Allergy

Shu, Shang An; Yuen, Agatha W.T.; Woo, Elena; Chu, Ka Hou; Kwan, Hoi Shan; Yang, Guo Xiang; Yang, Yao; Leung, Patrick S.C.

doi:10.1007/s12016-018-8723-y

Cited by 115 publications

(89 citation statements)

References 131 publications

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“…Clostridia species from the human gut microbiota attenuate allergic responses and inhibit FA development by promoting Treg cell generation or, alternatively, by inhibiting the systemic absorption of major food allergens [110]. B regulatory cells Breg promotion and tolerance induction by Clostridium butyricum in association with immunotherapy have also been demonstrated [111][112][113][114]. The gut microbiota composition can drive the development of either resistance or susceptibility to FA in the host.…”

Section: Beyond Immune Cellsmentioning

confidence: 99%

New Perspectives in Food Allergy

Martinis

Sirufo

Suppa

et al. 2020

IJMS

164

130

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The improvement of the knowledge of the pathophysiological mechanisms underlying the tolerance and sensitization to food antigens has recently led to a radical change in the clinical approach to food allergies. Epidemiological studies show a global increase in the prevalence of food allergy all over the world and manifestations of food allergy appear increasingly frequent also in elderly subjects. Environmental and nutritional changes have partly changed the epidemiology of allergic reactions to foods and new food allergic syndromes have emerged in recent years. The deepening of the study of the intestinal microbiota has highlighted important mechanisms of immunological adaptation of the mucosal immune system to food antigens, leading to a revolution in the concept of immunological tolerance. As a consequence, new prevention models and innovative therapeutic strategies aimed at a personalized approach to the patient affected by food allergy are emerging. This review focuses on these new perspectives and their practical implications in the management of food allergy, providing an updated view of this complex pathology.

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Section: Beyond Immune Cellsmentioning

confidence: 99%

New Perspectives in Food Allergy

Martinis

Sirufo

Suppa

et al. 2020

IJMS

164

130

View full text Add to dashboard Cite

show abstract

“…The requirement of the microbiota for inducing RORgt+ pTregs has long been appreciated (21,29). Antibiotic use, particularly in the first year of life, is strongly associated with later life food allergies (40), and would certainly induce microbial dysbiosis (41). Children with food allergies have distinct microbiotas from healthy children.…”

Section: Discussionmentioning

confidence: 99%

Regulatory T Cells Developing Peri-Weaning Are Continually Required to Restrain Th2 Systemic Responses Later in Life

et al. 2021

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Atopic disorders including allergic rhinitis, asthma, food allergy, and dermatitis, are increasingly prevalent in Western societies. These disorders are largely characterized by T helper type 2 (Th2) immune responses to environmental triggers, particularly inhaled and dietary allergens. Exposure to such stimuli during early childhood reduces the frequency of allergies in at-risk children. These allergic responses can be restrained by regulatory T cells (Tregs), particularly Tregs arising in the gut. The unique attributes of how early life exposure to diet and microbes shape the intestinal Treg population is a topic of significant interest. While imprinting during early life promotes the development of a balanced immune system and protects against immunopathology, it remains unclear if Tregs that develop in early life continue to restrain systemic inflammatory responses throughout adulthood. Here, an inducible deletion strategy was used to label Tregs at specified time points with a targeted mechanism to be deleted later. Deletion of the Tregs labeled peri-weaning at day of life 24, but not before weaning at day of life 14, resulted in increased circulating IgE and IL-13, and abrogated induction of tolerance towards new antigens. Thus, Tregs developing peri-weaning, but not before day of life 14 are continually required to restrain allergic responses into adulthood.

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“…While several studies have reported the beneficial effects of oral consumption of probiotics on some allergic diseases, including atopic dermatitis, allergic airways diseases, urticaria, and milk protein allergy [34,39,48,51], to date just one study is available in the literature on the effects of probiotic supplementation in SNAS patients [13]. In this work, Randazzo et al have reported preliminary findings suggesting that the treatment of patients with SNAS with L. reuteri (10 8 CFU per day) during a low-Ni diet led to an increase of intestinal lactic acid bacteria diversity and reduced gastrointestinal symptoms related to meals.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Low-Nickel Diet Combined with Oral Administration of Selected Probiotics on Patients with Systemic Nickel Allergy Syndrome (SNAS) and Gut Dysbiosis

Lombardi

Fiasca

Minelli³

et al. 2020

Nutrients

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Background: Nickel (Ni) oral consumption may elicit systemic reactions in patients affected by systemic nickel allergy syndrome (SNAS), including gastrointestinal symptoms, which in turn are associated with gut dysbiosis. We evaluated the effects of a low-Ni diet alone or in combination with the oral consumption of appropriate probiotics on Ni-sensitivity and urinary dysbiosis markers in SNAS patients. Methods: n = 51 patients with SNAS and concomitant intestinal dysbiosis were enrolled in the study. According to the urinary indican/skatole levels, quantified through a colorimetric and a high-performance liquid chromatographic method, respectively, patients were assigned to a dysbiosis type/grade and followed a low-Ni diet for three months. Along with the diet, 22 patients also consumed probiotics based on the dysbiosis type. In particular, a Lactobacilli- or Bifidobacteria-containing formulation was administered to patients with fermentative or putrefactive dysbiosis, respectively, while a broad-spectrum probiotic formulation containing both Lactobacilli and Bifidobacteria was administered to patients with mixed dysbiosis. After three months, patients were invited to repeat the Ni-stimulation and the dysbiosis tests. Results: The fermentative dysbiosis group represented the largest group followed by the mixed dysbiosis group, while only two patients had putrefactive dysbiosis. Overall, at three months of treatment in general (diet alone with or without probiotics), the Ni-sensitivity and dysbiosis levels were strongly ameliorated. The association of a low-Ni diet with a specific probiotic oral supplementation was significantly more effective in decreasing dysbiosis levels or reaching eubiosis than with diet alone. Conclusion: Our results, while confirming the benefits of a low-Ni diet in SNAS patients, strongly support that appropriate adjuvant treatment with probiotics significantly helps to improve intestinal dysbiosis or restore a healthy microbiota.

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Microbiota and Food Allergy

Cited by 115 publications

References 131 publications

New Perspectives in Food Allergy

New Perspectives in Food Allergy

Regulatory T Cells Developing Peri-Weaning Are Continually Required to Restrain Th2 Systemic Responses Later in Life

The Effects of Low-Nickel Diet Combined with Oral Administration of Selected Probiotics on Patients with Systemic Nickel Allergy Syndrome (SNAS) and Gut Dysbiosis

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