Microbiota and arthritis

Bravo-Blas, Alberto; Wessel, H; Milling, Simon

doi:10.1097/bor.0000000000000261

Cited by 17 publications

(8 citation statements)

References 53 publications

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“…In the context of musculoskeletal disease, an impaired gut barrier function has been implicated in rheumatoid arthritis and OA, and may present a viable therapeutic approach for disease management (Scher and Abramson, 2011 ). However, to date, cause and effect relations between rheumatoid arthritis and the gut microbiota are still being explored (Bravo-Blas et al, 2016 ).…”

Section: Obesity Bacterial Lipopolysaccharide (Lps) and Gut Microbimentioning

confidence: 99%

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

et al. 2018

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Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host, systemically, or locally. Obesity is now recognized as a chronic low-grade, systemic inflammatory state that predisposes to other chronic conditions including metabolic syndrome (MetS). Although obesity has received considerable attention regarding its pathophysiological link to chronic cardiovascular conditions and type 2 diabetes, the musculoskeletal (MSK) complications (i.e., muscle, bone, tendon, and joints) that result from obesity-associated metabolic disturbances are less frequently interrogated. As musculoskeletal diseases can lead to the worsening of MetS, this underscores the imminent need to understand the cause and effect relations between the two, and the convergence between inflammatory pathways that contribute to MSK damage. Muscle mass is a key predictor of longevity in older adults, and obesity-induced sarcopenia is a significant risk factor for adverse health outcomes. Muscle is highly plastic, undergoes regular remodeling, and is responsible for the majority of total body glucose utilization, which when impaired leads to insulin resistance. Furthermore, impaired muscle integrity, defined as persistent muscle loss, intramuscular lipid accumulation, or connective tissue deposition, is a hallmark of metabolic dysfunction. In fact, many common inflammatory pathways have been implicated in the pathogenesis of the interrelated tissues of the musculoskeletal system (e.g., tendinopathy, osteoporosis, and osteoarthritis). Despite these similarities, these diseases are rarely evaluated in a comprehensive manner. The aim of this review is to summarize the common pathways that lead to musculoskeletal damage and disease that result from and contribute to MetS. We propose the overarching hypothesis that there is a central role for muscle damage with chronic exposure to an obesity-inducing diet. The inflammatory consequence of diet and muscle dysregulation can result in dysregulated tissue repair and an imbalance toward negative adaptation, resulting in regulatory failure and other musculoskeletal tissue damage. The commonalities support the conclusion that musculoskeletal pathology with MetS should be evaluated in a comprehensive and integrated manner to understand risk for other MSK-related conditions. Implications for conservative management strategies to regulate MetS are discussed, as are future research opportunities.

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Section: Obesity Bacterial Lipopolysaccharide (Lps) and Gut Microbimentioning

confidence: 99%

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

et al. 2018

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“…A recent review (47) concluded most interventions targeting the microbiota, including dietary alterations and probiotics, have not yielded dramatic results. It bears emphasis, however, that most of these studies were conducted in adults.…”

Section: Therapeutic Potential Of Alterations In the Microbiotamentioning

confidence: 99%

The microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target?

Stoll

Cron

2016

Current Opinion in Rheumatology

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Purpose of review-There has been increasing interest in the contents and function of the microbiota, as it relates to pediatric inflammatory diseases. Here we discuss the factors underlying the development of the microbiota, its role in juvenile idiopathic arthritis (JIA), and prospects for therapeutic interventions in the microbiota.Recent findings-The human microbiota undergoes a succession of changes, until it reaches a mature form. A variety of early-life exposures, including mode of delivery and form of feeding, can affect the contents of the microbiota and possibly impact upon long-term risk of developing autoimmune diseases. The microbiota is altered in children with JIA, including elevated Bacteroides genus in JIA as a whole and decreased Faecalibacterium prausnitzii in pediatric spondyloarthritis. Although there is limited data so far indicating that microbiota-based therapies can result in therapeutic improvement of arthritis, most of the data is in adults and thus may not be applicable to children.Summary-Perturbations of the microbiota during childhood may result in the development of a microbiota associated with increased risk of pediatric rheumatic illness. Whether the microbiota can be targeted is a focus of ongoing research.

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“…Stool from malnourished patients showed the opposite effect. Gut microbiota are implicated not only in inflammatory processes and diseases such as inflammatory bowel diseases, diabetes and arthritis (Bravo-Blas, Wessel, & Milling, 2016;Miyoshi & Chang, 2017;Tilg & Moschen, 2014), but also in psychiatric diseases such as depression and anxiety (Luna & Foster, 2015). Kelly et al (2016), for example, showed that stool transplantation from depressed patients into gf-mice can transfer a depressive phenotype.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota alteration in adolescent anorexia nervosa does not normalize with short‐term weight restoration

Schulz

Belheouane

Dahmen

et al. 2020

Intl J Eating Disorders

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Objective Gut microbiota are linked to metabolic function, body weight regulation, and brain and behavioral changes. Alteration of gut microbiota is repeatedly demonstrated in adults with anorexia nervosa (AN) and transplantation of stool from adult patients with AN reduces weight gain, food consumption and food efficiency in germ‐free mice. No similar data are available for adolescents, who might differ from adults due to their shorter duration of illness. Method Nineteen female adolescent patients with AN at admission and after short‐term weight recovery were included in a longitudinal study and compared to 20 healthy controls (HC). DNA was extracted from stool samples and subjected to 16S rRNA gene sequencing and analysis. Group comparisons, indicator genera and simper analysis were applied. Taxon abundances at admission was used to predict inpatient treatment duration. Results Alpha diversity is increased in patients with AN after short‐term weight recovery, while beta diversity shows clear group differences with HC before and after weight gain. A reduction in Romboutsia and taxa belonging to Enterobacteriaceae at both timepoints and an increase in taxa belonging to Lachnospiraceae at discharge are most indicative of patients. Lachnospiraceae abundance at admission helped to predict shorter inpatient treatment duration. Discussion This pilot study provides first evidence of gut microbiota alterations in adolescent patients with AN that do not normalize with weight gain. If verified in larger studies, the predictive power of taxa belonging to Lachnospiraceae for clinical outcome could complement known predictors at admission, inform clinicians and serve as a target for nutritional interventions.

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Microbiota and arthritis

Cited by 17 publications

References 53 publications

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

The microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target?

Gut microbiota alteration in adolescent anorexia nervosa does not normalize with short‐term weight restoration

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