Microbiota and Aging. A Review and Commentary

García-Peña, Carmen; Álvarez‐Cisneros, Teresa; Quiroz-Báez, Ricardo; Friedland, Robert P.

doi:10.1016/j.arcmed.2017.11.005

Cited by 82 publications

(46 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, in humans a large number of environmental factors such as the place of residence (hospital, residential care setting or home) or the diet can influence the composition of the gut microbiota. For that matter, multiple factors should be taken into account when studying the relationship of the gut microbiota with the host Garcia-Pena et al, 2017). The germ-free mouse model offers a good opportunity FIGURE 6 | Relative abundance of lipid classes and ester-linked fatty acids in the liver of mice inoculated with different age-related microbiota.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Albouery

Buteau

Grégoire

et al. 2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Understanding the molecular mechanisms underlying the changes observed during aging is a prerequisite to design strategies to prevent age-related diseases. Aging is associated with metabolic changes, including alteration in the brain lipid metabolism. These alterations may contribute to the development of pathophysiological conditions. Modifications in the gut microbiota composition are also observed during aging. As communication axes exist between the gut microbiota and the brain and knowing that microbiota influences the host metabolism, we speculated on whether age-associated modifications in the gut microbiota could be involved in the lipid changes observed in aging brain. For that purpose, germ-free mice were colonized by the fecal microbiota of young or old donor mice. Lipid classes and fatty acid profiles were determined in the brain (cortex), plasma and liver by thin-layer chromatography on silica gel-coated quartz rods and gas chromatography. Gut colonization by microbiota of old mice resulted in a significant increase in total monounsaturated fatty acids (MUFA) and a significant decrease in the relative amounts of cholesterol and total polyunsaturated fatty acids (PUFA) in the cortex. Among the eight most represented fatty acids in the cortex, the relative abundances of five (C18:1n-9, C22:6n-3, C20:4n-6, C18:1n-7, and C20:1n-9) were significantly altered in mice inoculated with an aged microbiota. Liquid chromatography analyses revealed that the relative abundance of major species among phosphatidyl and plasmenylcholine (PC 16:0/18:1), phosphatidyl and plasmenylethanolamine (PE 18:0/22:6), lysophosphatidylethanolamine (LPE 22:6) and sphingomyelins (SM d18:1/18:0) were significantly altered in the cortex of mice colonized by the microbiota obtained from aged donors. Transplantation of microbiota from old mice also modified the lipid class and fatty acid content in the liver. Finally, we found that the expression of several genes involved in MUFA and PUFA synthesis (Scd1, Fads1, Fads2, Elovl2, and Elovl5) was dysregulated in mice inoculated with an Albouery et al.Microbiota Modulates Brain Lipid Composition aged microbiota. In conclusion, our data suggest that changes in gut microbiota that are associated with aging can impact brain and liver lipid metabolisms. Lipid changes induced by an aged microbiota recapitulate some features of aging, thus pointing out the potential role of microbiota alterations in the age-related degradation of the health status.

show abstract

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Albouery

Buteau

Grégoire

et al. 2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Additionally, inflammation has been considered to contribute to the pathogenesis of age-related disorders, and the condition often referred to as "inflammaging" [2]. Recently, increasing evidences indicated that the changes in microbiota composition have been associated with oxidative and inflammatory processes in the aging brain, as there are bidirectional communications between the brain and the gut microbiota, termed the microbiota-gut-brain axis, which enables gut microbes to communicate with the brain [3,4]. However, studies are still needed to elucidate how the microbiota-gut-brain axis works in these processes.…”

Section: Introductionmentioning

confidence: 99%

Serine Deficiency Exacerbates Inflammation and Oxidative Stress via Microbiota-Gut-Brain Axis in D-Galactose-Induced Aging Mice

Wang

Zhou²,

Deng

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Inflammation and oxidative stress play key roles in the process of aging and age-related diseases. Since serine availability plays important roles in the support of antioxidant and anti-inflammatory defense system, we explored whether serine deficiency affects inflammatory and oxidative status in D-galactose-induced aging mice. Male mice were randomly assigned into four groups: mice fed a basal diet, mice fed a serine-and glycine-deficient (SGD) diet, mice injected with D-galactose and fed a basal diet, and mice injected with D-galactose and fed an SGD diet. The results showed that D-galactose resulted in oxidative and inflammatory responses, while serine deficiency alone showed no such effects. However, serine deficiency significantly exacerbated oxidative stress and inflammation in D-galactose-treated mice. The composition of fecal microbiota was affected by Dgalactose injection, which was characterized by decreased microbiota diversity and downregulated ratio of Firmicutes/Bacteroidetes, as well as decreased proportion of Clostridium XIVa. Furthermore, serine deficiency exacerbated these changes. Additionally, serine deficiency in combination with D-galactose injection significantly decreased fecal butyric acid content and gene expression of short-chain fatty acid transporters (Slc16a3 and Slc16a7) and receptor (Gpr109a) in the brain. Finally, serine deficiency exacerbated the decrease of expression of phosphorylated AMPK and the increase of expression of phosphorylated NFκB p65, which were caused by D-galactose injection. In conclusion, our results suggested that serine deficiency exacerbated inflammation and oxidative stress in D-galactose-induced aging mice. The involved mechanisms might be partially attributed to the changes in the microbiotagut-brain axis affected by serine deficiency.

show abstract

“…Based on 16S rDNA sequencing of the total gut microbiota, a relationship has been observed between clinical phenotypes in the elderly and an “aged microbiota” (Fransen et al, ). This microbiota is particularly enriched in pathobionts and displays a decreased abundance of bacteria with anti‐inflammatory and immunomodulatory properties (Fransen et al, ; García‐Peña, Álvarez‐Cisneros, Quiroz‐Baez, & Friedland, ; Kim & Jazwinski, ; Komanduri, Gondalia, Scholey, & Stough, ; Lu & Wang, ; Mangiola, Nicoletti, Gasbarrini, & Ponziani, ; Nagpal et al, ; Pasolli et al, ; Ramos‐Molina, Queipo‐Ortuño, Lambertos, Tinahones, & Peñafiel, ; Reveles, Patel, Forney, & Ross, ; Riaz Rajoka et al, ; Vaiserman, Koliada, & Marotta, ). These bacteria include the genera Bacteroides , Alistipes , Parabacteroides , Faecalibacterium , Ruminococcus , Clostridium clusters IV and XIVa, Coprococcus , Roseburia , Coprobacillus , Anaerotruncus , Escherichia, Lactonifactor , Eubacterium , Lactobacillus , Bifidobacterium, and Akkermansia , and families such as Enterobacteriaceae, Eubacteriaceae , Porphyromonadaceae and Christensenellaceae .…”

Section: Introductionmentioning

confidence: 99%

Functional microbiome deficits associated with ageing: Chronological age threshold

et al. 2019

View full text Add to dashboard Cite

Composition of the gut microbiota changes during ageing, but questions remain about whether age is also associated with deficits in microbiome function and whether these changes occur sharply or progressively. The ability to define these deficits in populations of different ages may help determine a chronological age threshold at which deficits occur and subsequently identify innovative dietary strategies for active and healthy ageing. Here, active gut microbiota and associated metabolic functions were evaluated using shotgun proteomics in three well‐defined age groups consisting of 30 healthy volunteers, namely, ten infants, ten adults and ten elderly individuals. Samples from each volunteer at intervals of up to 6 months (n = 83 samples) were used for validation. Ageing gradually increases the diversity of gut bacteria that actively synthesize proteins, that is by 1.4‐fold from infants to elderly individuals. An analysis of functional deficits consistently identifies a relationship between tryptophan and indole metabolism and ageing (p < 2.8e−8). Indeed, the synthesis of proteins involved in tryptophan and indole production and the faecal concentrations of these metabolites are directly correlated (r2 > .987) and progressively decrease with age (r2 > .948). An age threshold for a 50% decrease is observed ca. 11–31 years old, and a greater than 90% reduction is observed from the ages of 34–54 years. Based on recent investigations linking tryptophan with abundance of indole and other “healthy” longevity molecules and on the results from this small cohort study, dietary interventions aimed at manipulating tryptophan deficits since a relatively “young” age of 34 and, particularly, in the elderly are recommended.

show abstract

Microbiota and Aging. A Review and Commentary

Cited by 82 publications

References 95 publications

Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Serine Deficiency Exacerbates Inflammation and Oxidative Stress via Microbiota-Gut-Brain Axis in D-Galactose-Induced Aging Mice

Functional microbiome deficits associated with ageing: Chronological age threshold

Contact Info

Product

Resources

About