Microbiota alteration of Chinese young male adults with high-status negative cognitive processing bias

Abstract

IntroductionEvidence suggests that negative cognitive processing bias (NCPB) is a significant risk factor for depression. The microbiota–gut–brain axis has been proven to be a contributing factor to cognitive health and disease. However, the connection between microbiota and NCPB remains unknown. This study mainly sought to explore the key microbiota involved in NCPB and the possible pathways through which NCPB affects depressive symptoms.MethodsData in our studies were collected from 735 Chinese young adults through a cross-sectional survey. Fecal samples were collected from 35 young adults with different levels of NCPB (18 individuals were recruited as the high-status NCPB group, and another 17 individuals were matched as the low-status NCPB group) and 60 with different degrees of depressive symptoms (27 individuals were recruited into the depressive symptom group, as D group, and 33 individuals were matched into the control group, as C group) and analyzed by the 16S ribosomal RNA sequencing technique.ResultsAs a result, the level of NCPB correlated with the degree of depressive symptoms as well as anxiety symptoms and sleep quality (p < 0.01). The β-diversity of microbiota in young adults was proven to be significantly different between the high-status NCPB and the low-status NCPB groups. There were several significantly increased bacteria taxa, including Dorea, Christensenellaceae, Christe -senellaceae_R_7_group, Ruminococcaceae_NK4A214_group, Eggerthellaceae, Family-XIII, Family_XIII_AD3011_group, Faecalibaculum, and Oscillibacter. They were mainly involved in pathways including short-chain fatty acid (SCFA) metabolism. Among these variable bacteria taxa, Faecalibaculum was found associated with both NCPB and depressive symptoms. Furthermore, five pathways turned out to be significantly altered in both the high-status NCPB group and the depressive symptom group, including butanoate metabolism, glyoxylate and dicarboxylate metabolism, propanoate metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, valine, leucine, and isoleucine degradation. These pathways were related to SCFA metabolism.DiscussionFecal microbiota is altered in Chinese young male adults with high status NCPB and may be involved in the biochemical progress that influences depressive symptoms.

Gut microbiota and hypertensive disorders in pregnancy: evidence from the Mendelian randomization study

“…and Dorea [33] have also been reported to produce SCFA with the function to effectively reduce blood pressure [34,35], which consistent with our MR results that the increased abundance of those gut microbiota were related to the lower risk of HDP.…”

“…But our multivariable MR analysis demonstrated that after adjusting T2D, the protective effect remained, which excluding the influence of confounding factors. Meanwhile, Bifidobacterium [ 9 ], Eubacterium ( ruminantium group ) [ 31 ], Tyzzerella3 [ 32 ], and Dorea [ 33 ] have also been reported to produce SCFA with the function to effectively reduce blood pressure [ 34 , 35 ], which consistent with our MR results that the increased abundance of those gut microbiota were related to the lower risk of HDP.…”

Fecal microbiota transplantation inhibited neuroinflammation of traumatic brain injury in mice via regulating the gut–brain axis

“…Furthermore, the abundance of Ruminococcaceae was higher in moderate or severe TBI patients compared to controls ( Urban et al., 2020 ). The relative abundance of Ruminococcaceae and Eggerthellaceae was significantly increased in high-status negative cognitive processing bias adults and cognitive dysfunction mice ( Han et al., 2020 ; Xu et al., 2023 ). On the contrary, in this study, FMT increased the relative abundance of Verrucomicrobiota , Akkermansiaceae , and Akkermansia in TBI mice.…”

Investigating the antidepressant effect of Ziyan green tea on chronic unpredictable mild stress mice through fecal metabolomics

“…There was a significant difference in the β-diversity of microbiota in young adults between high and low NCPB groups. Faecalibaculum abundance was shown to be significantly higher in the High-status NCPB treatment group ( Xu H. et al, 2023 ). It agrees with our findings; our study showed that the relative abundance of Bifidobacterium and Faecalibaculum significantly increased after Ziyan green tea intervention.…”