Microbiota affects mitochondria and immune cell infiltrations via alternative polyadenylation during postnatal heart development
Xiang Liu,
Yijia Shao,
Linjiang Han
et al.
Abstract:There is a growing body of evidence supporting the significant impact of microbiota on heart development. Alternative polyadenylation (APA) is a crucial mechanism for gene expression regulation and has been implicated in postnatal heart development. Nonetheless, whether microbiota can influence postnatal heart development through the regulation of APA remains unclear. Therefore, we conducted APA sequencing on heart tissues collected from specific pathogen-free (SPF) mice and germ-free (GF) mice at three differ… Show more
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