Microbiome studies in urology- where do we stand and where can we reach?

Shah, Utsav; Subramaniam, V.N.; Ashwin, S Tamhankar

doi:10.1016/j.ijmmb.2020.10.009

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…The influence of the microbiome on certain intestinal and extraintestinal diseases has received much interest in recent years due in part to greater accessibility to culture-independent methods such as the next-generation sequencing (NGS) based on 16S rRNA gene sequencing or metagenomic studies. Despite these advances, the urobiome (urinary microbiome) has not yet been much investigated [10]. Aspects including healthy urobiome, variations depending on sex, age, ethnicity, and geography, among others, still need to be defined [11].…”

Section: Introductionmentioning

confidence: 99%

Role of microbiome in kidney stone disease

Galán-Llopis¹,

Sánchez-Pellicer

Navarro-López

2022

Current Opinion in Urology

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Purpose of reviewThe process of renal stone formation is complex, multifactorial, and variable depending on the type of stone. The microbiome, whether by direct or indirect action, is a factor that both promotes the formation and protects from developing of renal stones. It is a highly variable factor due to the great interindividual and intraindividual variability that it presents. In recent years, with the incorporation of nonculture-based techniques such as the high-throughput sequencing of 16S rRNA bacterian gene, both intestinal and urinary microbiota have been deeply studied in various diseases such as the kidney stone disease. Recent findingsThis review has examined the new insights on the influence of the intestinal and urinary microbiome in nephrolithiasis disease and its usefulness as a diagnostic and prognostic tool, highlighting its contribution to the pathogenesis, its ability to modulate it and to influence disease development.

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Section: Introductionmentioning

confidence: 99%