Microbiome profiles are associated with cognitive functioning in 45-month-old children

Streit, Fabian; Prandovszky, Emese; Send, Tabea; Zillich, Lea; Frank, Josef; Sabunciyan, Sarven; Foo, Jerome C.; Sirignano, Lea; Lange, Bruno; Bardtke, Svenja; Hatfield, Glen; Witt, Stephanie H.; Gilles, Maria; Rietschel, Marcella; Deuschle, Michael; Yolken, Robert H.

doi:10.1016/j.bbi.2021.08.001

Cited by 24 publications

(32 citation statements)

References 76 publications

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“…In apparently healthy individuals, the association between the gut microbiome composition and cognitive functioning is also documented [ 15 – 24 ]. However, these studies have yielded inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

“…However, these studies have yielded inconsistent results. These inconsistent results may reflect limitations of the design of these studies, which is mainly cross-sectional [ 15 – 17 , 19 – 22 , 24 ]. Therefore, more prospective studies where the gut microbiome composition is profiled before the assessment of cognitive performance will help to draw a more definite conclusion and contribute to improving our knowledge on the influence of the gut microbiome on cognitive functioning.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, more prospective studies where the gut microbiome composition is profiled before the assessment of cognitive performance will help to draw a more definite conclusion and contribute to improving our knowledge on the influence of the gut microbiome on cognitive functioning. Additionally, previous studies have been among infants [ 18 , 23 ], children [ 24 ], middle-aged adults [ 20 ], and older adults [ 15 – 17 , 19 – 22 ]. Considering that the cognitive health in young adulthood positively correlates with memory and brain functioning in later life [ 25 ], studies among young adults would be necessary.…”

Section: Introductionmentioning

confidence: 99%

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A prospective investigation into the association between the gut microbiome composition and cognitive performance among healthy young adults

et al. 2022

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Background There is emerging evidence that the gut microbiome composition is associated with several human health outcomes, which include cognitive performance. However, only a few prospective epidemiological studies exist and none among young adults. Here we address the gap in the literature by investigating whether the gut microbiome composition is prospectively linked to fluid intelligence among healthy young adults. Methods Forty individuals (65% females, 26 years) from the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study provided a fecal sample for gut microbiome composition and subsequently (average of 166 days) completed a cognitive functioning test using the Cattell’s Culture Fair Intelligence Test, revised German version (CFT 20-R). The assessment of the gut microbiome at the genera level was by 16S rRNA V3-V4 Illumina sequencing. The relative abundance of 158 genera was summarized into bacterial communities using a novel data-driven dimension reduction, amalgamation. The fluid intelligence score was regressed on the relative abundance of the bacterial communities and adjusted for selected covariates. Results The 158 genera were amalgamated into 12 amalgams (bacterial communities), which were composed of 18, 6, 10, 14, 8, 10, 16, 13, 12, 12, 3, and 11 genera. Only the 14-genera bacterial community, named the “Ruminococcaceae- and Coriobacteriaceae-dominant community” was positively associated with fluid intelligence score (β = 7.8; 95% CI: 0.62, 15.65, P = 0.04). Conclusion Among healthy young adults, the abundance of a gut bacterial community was associated with fluid intelligence score. This study suggests that cognitive performance may potentially benefit from gut microbiome-based intervention.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A prospective investigation into the association between the gut microbiome composition and cognitive performance among healthy young adults

et al. 2022

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“…As anticipated, they have a pronounced influence on both newborn and mother’s homeostasis. This argument is strengthened by the studies conducted on infants ( n = 2028) [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ] and mothers ( n = 255) [ 78 , 79 ]. Astsinki et al [ 71 ] revealed using a clustering strategy that Bacteroidetes are associated with lower self-regulation capacity in contrast to a Bifidobacterium / Enterobacteriaceae cluster.…”

Section: Resultsmentioning

confidence: 99%

“…Analyzing separate lines of research, maternal smoking has proven to be dangerous and interacts with cognitive functioning as measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Presumably, this has to do with the relative abundance of Enterobacter asburiae [ 76 ]. The meconium microbiota is significantly influenced by anxiety, especially by a low level of Enterococcaceae [ 72 ], subsequently revealing that Akkermansia , Lactococcus , and Oscillospira ratio are positively associated with higher sociality scores [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

Doroftei

Ilie

Diaconu³

et al. 2022

Diagnostics

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Background: Antenatal depression (AND) and post-partum depression (PPD) are long-term debilitating psychiatric disorders that significantly influence the composition of the gut flora of mothers and infants that starts from the intrauterine life. Not only does bacterial ratio shift impact the immune system, but it also increases the risk of potentially life-threatening disorders. Material and Methods: Therefore, we conducted a narrative mini-review aiming to gather all evidence published between 2018–2022 regarding microflora changes in all three stages of pregnancy. Results: We initially identified 47 potentially eligible studies, from which only 7 strictly report translocations; 3 were conducted on rodent models and 4 on human patients. The remaining studies were divided based on their topic, precisely focused on how probiotics, breastfeeding, diet, antidepressants, exogenous stressors, and plant-derived compounds modulate in a bidirectional way upon behavior and microbiota. Almost imperatively, dysbacteriosis cause cognitive impairments, reflected by abnormal temperament and personality traits that last up until 2 years old. Thankfully, a distinct technique that involves fecal matter transfer between individuals has been perfected over the years and was successfully translated into clinical practice. It proved to be a reliable approach in diminishing functional non- and gastrointestinal deficiencies, but a clear link between depressive women’s gastrointestinal/vaginal microbiota and clinical outcomes following reproductive procedures is yet to be established. Another gut-dysbiosis-driving factor is antibiotics, known for their potential to trigger inflammation. Fortunately, the studies conducted on mice that lack microbiota offer, without a shadow of a doubt, insight. Conclusions: It can be concluded that the microbiota is a powerful organ, and its optimum functionality is crucial, likely being the missing puzzle piece in the etiopathogenesis of psychiatric disorders.

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The impact of maternal smoking during pregnancy and the age of smoking initiation on incident dementia: A prospective cohort study

Liu,

Xiao,

Zheng

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONThe impact of early‐life tobacco exposure on dementia has remained unknown.METHODSUsing the UK Biobank, the associations of maternal smoking during pregnancy (MSDP) and age of smoking initiation (ASI) with the onset time of all‐cause dementia were estimated with accelerated failure time models. The effects of MSDP and ASI on brain structure and their genetic correlation to Alzheimer's disease (AD) were analyzed. A Mendelian randomization (MR) analysis was conducted.RESULTSThe time ratios for smokers starting in childhood, adolescence, and adulthood (vs never smokers) were 0.87 (0.76 to 0.99), 0.92 (0.88 to 0.96), and 0.95 (0.89 to 1.01). MSDP and smoking in adolescence altered many brain regions, including the hippocampus. In genetic analysis, MSDP was genetically and causally linked to AD, and a younger ASI was genetically correlated to a higher AD risk.DISCUSSIONEarly‐life smoking accelerated dementia onset and was genetically correlated to AD. MSDP demonstrated genetic and causal linkage to AD risks.Highlights Unlike the commonly used Cox proportional hazards model, this article uses a parametric survival analysis method – the accelerated failure model – to explore the relationship between exposure to onset time. It can be used as an alternative method when the proportional hazards assumption is not met. Genetic analyses including genetic correlation study and MR analysis and brain structure analyses were conducted to support our findings and explore the potential mechanisms. The study reveals the relationship between different smoking initiation periods and the onset time of dementia and shows that earlier smoking exposure has a more significant impact on dementia. It emphasizes the importance of preventing early smoking. In the future, more research focusing on the relationship between early exposure and dementia is called for to provide more detailed prevention measures for dementia that cover all age groups.

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Microbiome profiles are associated with cognitive functioning in 45-month-old children

Cited by 24 publications

References 76 publications

A prospective investigation into the association between the gut microbiome composition and cognitive performance among healthy young adults

A prospective investigation into the association between the gut microbiome composition and cognitive performance among healthy young adults

An Updated Narrative Mini-Review on the Microbiota Changes in Antenatal and Post-Partum Depression

The impact of maternal smoking during pregnancy and the age of smoking initiation on incident dementia: A prospective cohort study

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