Microbiome influences on allergy in mice and humans

Marsland, Benjamin J.; Salami, Olawale

doi:10.1016/j.coi.2015.07.005

Cited by 45 publications

(51 citation statements)

References 74 publications

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“…Since food allergy is a public health problem in humans, with a prevalence of between 5 and 8%, adjuvants able to break oral tolerance are probably quite abundant. Allergies have been associated with altered diversity and composition of gut microbiota [2-4, 8], and we hypothesize that effects by adjuvants on the microbiota composition are one of their mode of action. In the present model we used CT, a commonly used adjuvant in animal studies of food allergy [24], serving as a model adjuvant, since oral exposure to the allergen alone does not induce food allergy.…”

Section: Discussionmentioning

confidence: 99%

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

Andreassen

Rudi

Angell

et al. 2018

Int Arch Allergy Immunol

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Background: The incidence of food allergies in western countries has increased in recent decades. Objectives: To study the association between gut bacterial microbiota composition, short-chain fatty acids (SCFAs) and food allergy in a mouse model. Methods: After oral immunizations with the human food allergen lupine with the adjuvant cholera toxin (CT) (or buffer in controls), sensitization and anaphylactic responses were determined. Gastrointestinal content was collected from the distal ileum, cecum, colon, and fecal pellets, and the bacterial diversity and composition was determined by deep sequencing of the 16S rRNA gene. SCFAs in gastrointestinal content supernatants were determined by gas chromatography. Results: The microbiota signatures were profoundly affected by allergen immunization. Ten operational taxonomic units (OTUs) were significantly different between immunized and control animals for at least one of the intestinal segments; eight of these OTUs belonged to the Clostridia class. Although consistent across all four gut segments, the colon showed the highest number of OTUs significantly associated with allergic immunization. SCFA levels in the cecum were also altered by immunization. Conclusions: Allergen immunization with CT in the present food allergy model induced profound changes in the microbiome composition and SCFA production. The result suggests that the colon may be the most sensitive gut segment for investigating changes in the gut microbiome.

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Section: Discussionmentioning

confidence: 99%

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

Andreassen

Rudi

Angell

et al. 2018

Int Arch Allergy Immunol

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show abstract

“…It is possible that customized dietary interventions could prevent the development of this disease. Studies in pregnant mice suggest that a low-fiber diet (common in obesogenic diets) increases the risk of developing allergic asthma through the effects on the gut microbiome and immune cell development, 79 whether increasing dietary fiber content might be effective for the prevention of asthma is not known. A high-fat diet is commonly linked to obesity, and consumption of a highfat diet can increase airway inflammation in patients with asthma 80 : whether altering the fat composition of the diet might prevent the development of asthma and/or improve asthma control is not known.…”

Section: Implications Of the Relationship Between Asthma And Obesitymentioning

confidence: 99%

The Asthma–Obesity Epidemic

Dixon¹

2015

Primary Prevention Insights

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Obesity is a risk factor for the development of asthma. Understanding this link between obesity and asthma has major public health implications for developing strategies to prevent the development of asthma and to guide the management of such patients. Obese patients with asthma experience poor asthma control, worse asthma-specific quality of life, and limited response to corticosteroids. This review provides a succinct summary of the current body of literature on the epidemiological relationship between asthma and obesity, the different phenotypes of asthma in obesity, and data on the efficacy of weight loss and discusses the potential role of primary prevention efforts for the current asthma epidemic.

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“…So interest is now focused on how microbiomes might be manipulated therapeutically, including by dietary changes, in order to move from disease-promoting "dysbiotic" microbiomes to those that are more conducive to health. 57,58 However, there are many challenges to instituting a "microbiome management plan" that can be individualized based on the characteristics of the particular subject. These include, but are not limited to, the following.…”

Section: Prevention Preventing the Development Of Diseasementioning

confidence: 99%

Toward precision medicine and health: Opportunities and challenges in allergic diseases

2016

Journal of Allergy and Clinical Immunology

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Abstract"Precision Medicine" (also called "Personalized", "Stratified" or "P4" Medicine) can be defined as the tailoring of preventive measures and medical treatments to the characteristics of each patient to obtain the best clinical outcome for each person while, ideally, also enhancing the costeffectiveness of such interventions for individuals and society. Clearly, the "best clinical outcome" in allergic diseases is not to get them in the first place. To emphasize the importance of disease prevention, a critical component of Precision Medicine can be referred to as "Precision Health", defined herein as the use of all available information pertaining to specific individuals (including family history, individual genetic and other biometric information, and exposures to risk factors for developing or exacerbating disease), as well as features of their environments, to sustain and enhance health and prevent the development of disease. In this article, I will provide a personal perspective on how the "Precision Health-Precision Medicine" approach can be applied to the related goals of preventing the development of allergic disorders and providing the most effective diagnosis, "disease monitoring", and care for those who suffer from these prevalent diseases. I will also mention some of the existing and potential challenges to achieving these ambitious goals.

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Microbiome influences on allergy in mice and humans

Cited by 45 publications

References 74 publications

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

The Asthma–Obesity Epidemic

Toward precision medicine and health: Opportunities and challenges in allergic diseases

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Microbiome influences on allergy in mice and humans

Cited by 45 publications

References 74 publications

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

The Asthma&ndash;Obesity Epidemic

Toward precision medicine and health: Opportunities and challenges in allergic diseases

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Product

Resources

About

The Asthma–Obesity Epidemic