Microbiome in Cystic Fibrosis

Immune Response in Cystic Fibrosis: Interplay between the Host and Microbes

“…Studies focusing on the relationship between microbiome and inflammation in people with CF (pwCF) showed that the decrease in diversity is linked to an increase in inflammation. The change in the microbiome from diverse states to almost a mono-specific state is associated with chronic bacterial lung infection, especially by the Gram-negative bacteria Pseudomonas aeruginosa [2]. The establishment of such an infection is a major step in the progression of lung disease severity and is known to induce excessive lung inflammation and impair airway epithelial barrier function [1].…”