Microbiome, demystifying the role of microbial communities in the biosphere

Wommack, K. Eric; Ravel, Jacques

doi:10.1186/2049-2618-1-1

Cited by 121 publications

(103 citation statements)

References 6 publications

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“…Relevant to BV, increased production of succinate supports the growth of anaerobic bacteria. This study 81 demonstrates the ability of L. iners to regulate gene expression depending on environmental factors ( i.e. , bacterial composition, pH) and highlights the need for metatranscriptomic analyses to fully resolve species-specific interactions in the context of the host and community.…”

Section: Bacterial Vaginosismentioning

confidence: 75%

“…Among the vaginal lactobacilli L. iners is unique in it's ablility to survive in a BV-like environment. In a recent study, Macklaim et al 81 used RNA-seq strategies to describe the difference in gene expression profiles of L. iners isolated from healthy women and women with BV environments 81,82 . These studies showed that L. iners upregulates expression of a cholesterol-dependent cytolysin (CDC) in a woman with BV.…”

Section: Bacterial Vaginosismentioning

confidence: 99%

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The Changing Landscape of the Vaginal Microbiome

Huang¹,

Fettweis²,

Brooks

et al. 2014

Clinics in Laboratory Medicine

160

134

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Section: Bacterial Vaginosismentioning

confidence: 75%

Section: Bacterial Vaginosismentioning

confidence: 99%

The Changing Landscape of the Vaginal Microbiome

Huang¹,

Fettweis²,

Brooks

et al. 2014

Clinics in Laboratory Medicine

160

134

View full text Add to dashboard Cite

“…Infection with norovirus significantly alters the gut flora in humans (57). Interestingly MNV infection does not alter the gut microbiota in mice, yet MNV-induced pathologies have been shown to be microbiota-dependent (58). Genetically susceptible mice (ATG16L1 HM ) infected with persistent MNV induce intestinal inflammation similar to Crohn’s disease (59).…”

Section: Unclear Effects Of the Microbiota On Virusesmentioning

confidence: 99%

Viruses and the Microbiota

2014

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Every surface of the human body is colonized by a diverse microbial community called the microbiota, yet the impact of microbiota on viruses is unclear. Recent research has advanced our understanding of how microbiota influence viral infection. Microbiota inhibit infection of some viruses and promote infection of other viruses. These effects can occur through direct and/or indirect effects on the host and/or virus. This review examines the known effects and mechanisms by which the microbiota influence mammalian virus infections. Furthermore, we suggest strategies for future research on how microbiota impact viruses. Overall, microbiota may influence a wide array of viruses through diverse mechanisms, making the study of virus-microbiota interactions a fertile area for future investigation.

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“…50 Furthermore, consortia of specific bacterial species that protect against CDI in mice and humans have little phylogenetic similarity to C difficile . 5051 Of course, phylogenetically dissimilar bacterial species may still compete for the same limiting nutrients. Conversely, it is not known whether NTCD strains necessarily have the same nutritional requirements as TCD.…”

Section: Introductionmentioning

confidence: 99%

“…Patients were given a mixture of 33 strains of bacteria, isolated from the stool of 1 healthy donor. 51 The donor was chosen according to a standard FMT screening protocol, and was a non-smoker, with an average body-mass index, born by normal vaginal delivery and breastfed as an infant, with no exposure to antibiotics in the past 10 years. Using culture techniques developed on principles of microbial ecology, researchers used a modified continuous culture chemostat system to isolate intestinal bacteria from the donor stool, which were then characterized and banked (Figure 2A).…”

Section: Introductionmentioning

confidence: 99%

From Stool Transplants to Next-Generation Microbiota Therapeutics

2014

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The epidemic of Clostridium difficile infection fueled by new virulent strains of the organism has led to increased use of fecal microbiota transplantation (FMT). The procedure is effective for even the most desperate cases, after failure of multiple courses of antibiotics. The approach recognizes microbiota to be integral to normal human physiology, and microbiota being used in FMT represents a new class of therapeutics. Imbalance in the composition and altered activity of the microbiota are associated with many diseases. Consequently, there is growing interest in applying FMT to non-C. difficile indications. However, this may succeed only if microbiota therapeutics are developed systematically, based on mechanistic understanding, and applying updo-date principles of microbial ecology. We discuss two pathways in development of this new therapeutic class: whole microbial communities separated from donor stool and an assembly of specific fecal microorganisms grown in vitro.

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Microbiome, demystifying the role of microbial communities in the biosphere

Cited by 121 publications

References 6 publications

The Changing Landscape of the Vaginal Microbiome

The Changing Landscape of the Vaginal Microbiome

Viruses and the Microbiota

From Stool Transplants to Next-Generation Microbiota Therapeutics

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