Microbiome Characteristics in Early Threatened Miscarriage Study (MCETMS): a study protocol for a prospective cohort investigation in China

Chen, Xiaofeng; Guo, Yinan; Zhang, Yingxuan; Chen, Si; Zhang, Huimin; Huang, Xuge; Luo, Songping; Deng, Gaopi; Gao, Jie

doi:10.1136/bmjopen-2021-057328

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…In the other half, the threatened miscarriage progresses to an inevitable miscarriage, resulting in pregnancy loss ( Wahabi et al., 2011 ; Wahabi et al., 2018 ). Research suggests that dysbiosis in the vaginal microbiome increase the risk of threatened miscarriage ( Chen et al., 2022 ).…”

Section: Miscarriage: Types and Symptomsmentioning

confidence: 99%

Role of the vaginal microbiome in miscarriage: exploring the relationship

Saadaoui,

Singh,

Ortashi

et al. 2023

Front. Cell. Infect. Microbiol.

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Miscarriage is a devastating pregnancy loss that affects many women worldwide. It is characterized as a spontaneous miscarriage that occurs before 20 weeks of gestation which affects more than 25% of pregnancies. While the causes of miscarriage are complex and multifactorial, recent research has suggested a potential role of the vaginal microbiota. The vaginal microbiome is a dynamic ecosystem of microbes that are essential for preserving vaginal health and avoiding infections. Vaginal dysbiosis has been accompanied with numerous adverse pregnancy complications, such as preterm birth. However, the effect of the vaginal microbiome in miscarriage is not fully understood. This review aims to investigate the link between vaginal microbiota and miscarriage. Also, we investigate the various mechanisms through which the vaginal microbiota may affect miscarriage. Additionally, we examine the implications of these research findings, specifically the possibility of vaginal microbiome screening and targeted interventions to prevent miscarriage.

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Section: Miscarriage: Types and Symptomsmentioning

confidence: 99%

Role of the vaginal microbiome in miscarriage: exploring the relationship

Saadaoui,

Singh,

Ortashi

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Symptoms can vary from blood spotting to potentially fatal shock. Once it proceeds to the dilation of the cervix, a miscarriage is inevitable [1,2]. Threatened miscarriage occurs in approximately 15-20% of all pregnancies and may lead to pregnancy complications including preterm delivery, foetal growth detainment, preeclampsia, eclampsia, the preterm premature rupture of membranes, placental abruption, and stillbirth in future pregnancies [3].…”

Section: Introductionmentioning

confidence: 99%

Exploring Progesterone Deficiency in First-Trimester Miscarriage and the Impact of Hormone Therapy on Foetal Development: A Scoping Review

Bataa,

Abdelmessih,

Hanna

2024

Children

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Background and Objectives: Progesterone deficiency during pregnancy may lead to various complications, including first-trimester miscarriage, which is the most common pregnancy complication. However, progesterone therapy may play a role in pregnancy maintenance and foetal development. The aim of this scoping review is to present evidence on the link between progesterone deficiency and first-trimester miscarriage among pregnant women and assess the impact of progesterone therapy on foetal development. Methods: A comprehensive global systematic search of mainly primary research studies was conducted using several databases. Peer-reviewed studies published between 2010 and 2023 were included. The scoping review was conducted using the framework outlined by the Joanna Briggs Institute (JBI) and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses—Extension for Scoping Reviews (PRISMA-ScR) statement. Results: Twenty-three articles (which included 35,862 participants) were included in the analysis. Most studies were conducted in mid- to high-income countries. All 23 articles reported a significant positive relationship between progesterone deficiency and first-trimester miscarriage. Furthermore, the majority of studies reported a higher risk of miscarriage when lower levels of progesterone are combined with other declined hormones. While most studies reported that progesterone therapy may reduce the rate of first-trimester miscarriage among pregnant women, no evidence of health-related harm to offspring development was reported. Conclusions: The findings from this systematic–scoping review indicate possible benefits of progesterone replacement therapy in maintaining a healthy pregnancy and foetal development. Rigorous studies that include large sample sizes and systematic reviews are required to confirm these findings further.

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Microbiome Characteristics in Early Threatened Miscarriage Study (MCETMS): a study protocol for a prospective cohort investigation in China

Cited by 2 publications

References 37 publications

Role of the vaginal microbiome in miscarriage: exploring the relationship

Role of the vaginal microbiome in miscarriage: exploring the relationship

Exploring Progesterone Deficiency in First-Trimester Miscarriage and the Impact of Hormone Therapy on Foetal Development: A Scoping Review

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