Microbiome and Colorectal Cancer Management

Alrahawy, Mahmoud; Javed, Saryia; Atif, Haitham; Elsanhoury, Kareem; Mekhaeil, Kamel; Eskander, George Hany

doi:10.7759/cureus.30720

Cited by 3 publications

(2 citation statements)

References 100 publications

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“…This review highlights the importance of a healthy gut microbiome for proper response in the case of immunotherapy and chemotherapy in colorectal cancer. Dysbiosis has been associated with the tumoral process in colorectal neoplasia; furthermore, according to cited studies, FMT may improve gastrointestinal symptoms during chemotherapy and increase the survival rate of the patients [ 76 , 77 ].…”

Section: Fmt Improves Response To Chemo and Immunotherapy In Colorect...mentioning

confidence: 99%

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia—A Literature Review

Boicean,

Bratu,

Bacila

et al. 2023

Pathogens

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In a mutually beneficial connection with its host, the gut microbiota affects the host’s nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types of disease and gut dysbiosis or specific microorganisms. Fecal microbiota transplantation (FMT) is strongly advised for the treatment of recurrent or resistant Clostridium difficile infection (CDI) due to its outstanding clinical effectiveness against CDI. The therapeutic potential of FMT for other disorders, particularly inflammatory bowel diseases and malignancies, is currently gaining more and more attention. We summarized the most recent preclinical and clinical evidence to show the promise of FMT in the management of cancer as well as complications related to cancer treatment after reviewing the most recent research on the gut microbiota and its relationship to cancer.

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Section: Fmt Improves Response To Chemo and Immunotherapy In Colorect...mentioning

confidence: 99%

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia—A Literature Review

Boicean,

Bratu,

Bacila

et al. 2023

Pathogens

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“…Hungatella hathaway, Clostridium asparagiforme, Klebsiella oxytoca, and E. coli increased in CRC patients with sequence changes in these two genes. Several prospective studies have linked high dietary and blood choline levels to CRC [19]. DNA methylation and synthesis require choline, folate, and vitamin B12.…”

Section: Effect Of Red Meat and Junk Foodmentioning

confidence: 99%

Interaction between Gut Microbiota and Dendritic Cells in Colorectal Cancer

Zaher,

Basingab

2023

Biomedicines

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Colorectal cancer (CRC) is a malignancy that manifests in serial stages and has been observed to have an escalating incidence in modern societies, causing a significant global health problem. The development of CRC is influenced by various exogenous factors, including lifestyle, diet, nutrition, environment, and microbiota, that can affect host cells, including immune cells. Various immune dysfunctions have been recognized in patients with CRC at different stages of this disease. The signature of microbiota in the development of CRC—inflammation related to obesity, diet, and reactive host cells, such as dendritic cells (DCs)—has been highlighted by many studies. This study focuses on DCs, the primary cellular mediators linking innate and adaptive immune responses against cancer. In addition, this review focuses on the role of microbiota in dysbiosis and how it affects DCs and, in turn, the immune response and progression of CRC by stimulating different sets of T cells. Additionally, DCs’ role in protecting this delicate balance is examined. This is to determine how gene yields of commensal microbiota may be critical in restoring this balance when disrupted. The stages of the disease and major checkpoints are discussed, as well as the role of the C-type lectin receptor of immature DCs pattern recognition receptor in CRC. Finally, based on a thorough examination of worldwide clinical studies and recent advancements in cancer immunotherapy, it is recommended that innovative approaches that integrate DC vaccination strategies with checkpoint inhibitors be considered. This approach holds great promise for improving CRC management.

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Construction of a novel microbial abundance prognostic risk (MAPR) model for predicting prognosis in CRC - based on bioinformatics

Chen

Lin

Zhuang

et al. 2023

Preprint

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Background Previous studies have demonstrated the significant role of the microbiome in the prognosis of colorectal cancer (CRC) patients. However, few studies have utilized bioinformatics to analyze the prognostic value of the microbiome in CRC. In this study, we constructed a CRC microbial abundance prognostic risk (MAPR) model and evaluated its prognostic value. Methods The TCGA CRC microbiome data (TCGA-CRC-microbiome) was downloaded from the cBioPortal website. Univariate, LASSO, and multivariate Cox regression analyses were performed to investigate the relationship between CRC microbial abundance and survival. The MAPR model was constructed based on the above analyses. The predictive ability of the MAPR model was evaluated using Kaplan-Meier (KM) survival curves, receiver operating characteristic (ROC) curves, independent prognostic analysis, and nomogram models. Results Using 11 microbial genera which exhibited adverse overall survival (OS) in CRC patients from overall 1406 microbes in the TCGA-CRC microbiome dataset to construct a MAPR model. This model was constructed and assessed for prognostic value using different survival endpoints. The results indicated that the high-risk group had shorter OS, progression-free interval (PFI), disease-specific survival (DSS), and disease-free interval (DFI). High-risk status served as an independent adverse prognostic factor, with greater prognostic value than other clinical indicators. Compared to the MAPR-unincorporated CRC nomogram, the four nomograms incorporating MAPR significantly improved the predictive ability. Conclusion The successful establishment of CRC's MAPR and its unique prognostic value provide a novel perspective for further investigations into the prognostic mechanisms of CRC patients.

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Microbiome and Colorectal Cancer Management

Cited by 3 publications

References 100 publications

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia—A Literature Review

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia—A Literature Review

Interaction between Gut Microbiota and Dendritic Cells in Colorectal Cancer

Construction of a novel microbial abundance prognostic risk (MAPR) model for predicting prognosis in CRC - based on bioinformatics

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