Microbiome Analysis of Carious Lesions in Pre-School Children with Early Childhood Caries and Congenital Heart Disease

Schulz‐Weidner, Nelly; Weigel, Markus; Turujlija, Filip; Komma, Kassandra; Mengel, Jan Philipp; Schlenz, Maximiliane Amelie; Bulski, Julia Camilla; Krämer, Norbert; Hain, Torsten

doi:10.3390/microorganisms9091904

Cited by 8 publications

(12 citation statements)

References 55 publications

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“…Olsenella is a genus belonging to the Actinobacteria phylum. Studies have shown that it is highly relevant to dysbiosis and inflammation [ 38 , 39 ]. Ruminococcaceae-UCG -009 has been reported to be pathogenic bacteria when stimulated by stress, leading to an increased intestinal permeability, disrupted epithelial barriers, and intestinal diseases [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

et al. 2022

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This study aims to explore the effects of modified montmorillonite (MMT, copper loading) on the growth performance, gut microbiota, intestinal barrier, antioxidative capacity and immune function of broilers. Yellow-feathered broilers were randomly divided into control (CTR), modified montmorillonite (MMT), and antibiotic (ANTI) groups. Results revealed that MMT supplementation increased the BW and ADG and decreased the F/R during the 63-day experiment period. 16S rRNA sequencing showed that MMT modulated the cecal microbiota composition of broilers by increasing the relative abundance of two phyla (Firmicutes and Bacteroidetes) and two genera (Bacteroides and Faecalibacterium) and decreasing the abundance of genus Olsenella. MMT also improved the intestinal epithelial barrier indicated by the up-regulated mRNA expression of claudin-1, occludin, and ZO-1 and the increased length of microvilli in jejunum and the decreased levels of DAO and D-LA in serum. In addition, MMT enhanced the immune function indicated by the increased levels of immunoglobulins, the decreased levels of MPO and NO, the down-regulated mRNA expression of IL-1β, IL-6, and TNF-α, and the up-regulated mRNA expression of IL-4 and IL-10. Moreover, MMT down-regulated the expression of jejunal TLRs/MAPK/NF-κB signaling pathway-related genes (TLR2, TLR4, Myd88, TRAF6, NF-κB, and iNOS) and related proteins (TRAF6, p38, ERK, NF-κB, and iNOS). In addition, MMT increased the antioxidant enzyme activities and the expression of Nrf2/HO-1 signaling pathway-related genes and thereby decreased the apoptosis-related genes expression. Spearman’s correlation analysis revealed that Bacteroides, Faecalibacterium, and Olsenella were related to the inflammatory index (MPO and NO), oxidative stress (T-AOC, T-SOD, and CAT) and intestinal integrity (D-LA and DAO). Taken together, MMT supplementation improved the growth performance of broilers by modulating intestinal microbiota, enhancing the intestinal barrier function, and improving inflammatory response, which might be mediated by inhibiting the TLRs/MAPK/NF-κB signaling pathway, and antioxidative capacity mediated by the Nrf2/HO-1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

et al. 2022

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“…Therefore, our results provide a reference for further exploring the relationship between Olsenella and MetS. Several studies have indicated a significant association between Olsenella and dysbiosis as well as inflammation [59][60][61]. Dysbiosis and inflammation in the gut can compromise the integrity of Fig.…”

Section: Discussionmentioning

confidence: 59%

Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study

Yan,

Wang,

Bao

et al. 2024

Cell Biosci

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Background Observational studies have reported that gut microbiota composition is associated with metabolic syndrome. However, the causal effect of gut microbiota on metabolic syndrome has yet to be confirmed. Methods We performed a bidirectional Mendelian randomization study to investigate the causal effect between gut microbiota and metabolic syndrome in European population. Summary statistics of gut microbiota were from the largest available genome-wide association study meta-analysis (n = 13,266) conducted by the MiBioGen consortium. The summary statistics of outcome were obtained from the most comprehensive genome-wide association studies of metabolic syndrome (n = 291,107). The inverse-variance weighted method was applied as the primary method, and the robustness of the results was assessed by a series of sensitivity analyses. Results In the primary causal estimates, Actinobacteria (OR = 0.935, 95% CI = 0.878–0.996, P = 0.037), Bifidobacteriales (OR = 0.928, 95% CI = 0.868–0.992, P = 0.028), Bifidobacteriaceae (OR = 0.928, 95% CI = 0.868–0.992, P = 0.028), Desulfovibrio (OR = 0.920, 95% CI = 0.869–0.975, P = 0.005), and RuminococcaceaeUCG010 (OR = 0.882, 95% CI = 0.803–0.969, P = 0.009) may be associated with a lower risk of metabolic syndrome, while Lachnospiraceae (OR = 1.130, 95% CI = 1.016–1.257, P = 0.025), Veillonellaceae (OR = 1.055, 95% CI = 1.004–1.108, P = 0.034) and Olsenella (OR = 1.046, 95% CI = 1.009–1.085, P = 0.015) may be linked to a higher risk for metabolic syndrome. Reverse MR analysis demonstrated that abundance of RuminococcaceaeUCG010 (OR = 0.938, 95% CI = 0.886–0.994, P = 0.030) may be downregulated by metabolic syndrome. Sensitivity analyses indicated no heterogeneity or horizontal pleiotropy. Conclusions Our Mendelian randomization study provided causal relationship between specific gut microbiota and metabolic syndrome, which might provide new insights into the potential pathogenic mechanisms of gut microbiota in metabolic syndrome and the assignment of effective therapeutic strategies.

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“…All of them were affected by early childhood caries. The microbiome profile indicated that Fusobacterium, Prevotella, Capnocytophaga, and Oribacterium were more abundant in the CC group, while Lactobacillus and Rothia were predominant in the healthy control [27].…”

Section: Resultsmentioning

confidence: 98%

Evidence of the association between endodontic infections and heart diseases: a systematic review

Ribeiro¹,

Santos²,

Assunção³

et al. 2022

MedNEXT

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Introduction: In the scenario of heart diseases, especially cardiovascular diseases (CVD), there are several predictors of these diseases, including diseases related to oral health. Objective: It was to analyze through clinical studies the association of diseases of the oral cavity with cardiovascular diseases, to point out the main causes and treatments for future clinical studies. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from January 2022 to April 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: In line with the objective proposed in the present study, the results concluded that the association between chronic endodontic infection and CVD cannot be disregarded, although it is of limited quality evidence at the moment. Thus, clinical studies observed that the risk of diagnosing CVD in patients with chronic endodontic infection was 1.38 times those without infection. Furthermore, early childhood caries showed that the microbiome profile composed of Fusobacterium, Prevotella, Capnocytophaga, and Oribacterium were more abundant in the group with congenital heart disease than in the group without congenital heart disease. Also, the greater number of missing teeth was associated with an increased risk of a first acute myocardial infarction, and endodontic inflammatory disease may contribute as an independent risk factor for cardiovascular diseases.

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Microbiome Analysis of Carious Lesions in Pre-School Children with Early Childhood Caries and Congenital Heart Disease

Cited by 8 publications

References 55 publications

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

Causal effect between gut microbiota and metabolic syndrome in European population: a bidirectional mendelian randomization study

Evidence of the association between endodontic infections and heart diseases: a systematic review

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