Microbiology of surgical site infections in patients with cancer: A 7-year review

Hernaiz-Leonardo, Juan Carlos; Golzarri, María F.; Cornejo‐Juárez, Patricia; Volkow, Patricia; Velázquez, Consuelo; Ostrosky-Frid, Mauricio; Vilar‐Compte, Diana

doi:10.1016/j.ajic.2017.02.023

Cited by 20 publications

(24 citation statements)

References 24 publications

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“…In spite of the limitations of the study, among the 3733 patients enrolled before implementation of the checklist and 3955 patients enrolled after implementation of the checklist, the rate of death was 1.5% before the checklist was introduced and declined to 0.8% afterwards (p = 0.003). Inpatient complications occurred in 11.0% of patients at baseline and in 7.0% after introduction of the checklist (p < 0.001) (Haynes et al, 2009). Within the measures, 'prophylactic antibiotic given appropriately' improved significantly in the post-intervention period in the eight hospitals (p < 0.001).…”

Section: Discussionmentioning

confidence: 95%

“…In terms of SSI prevention in non-cardiac surgery, Haynes et al published a prospective study of pre-intervention and postintervention periods at eight hospitals in eight cities in different countries. Four of these countries were included in the present systematic review of developing countries (India, Jordan, Philippines, and Tanzania) (Haynes et al, 2009). The intervention phase involved a 19-item WHO safe-surgery checklist implementation program, which was based on the 2008 WHO evidence-based recommendations to reduce the rate of major surgical complications (Tan et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…,Gao et al (2010),Gil-Londoño et al (2016),Giri et al (2008),Hafez et al (2012),Hao et al (2013),Hernaiz-Leonardo et al (2017),Hey et al (2017),Ibrahim et al (2014),Jyothirmayi et al (2017),Kanafani et al (2006),Khan et al (2010),Khan et al (2011),Ledur et al (2011),Lee et al (2007),Lee et al (2010),Lee et al (2015),Legesse Laloto et al (2017),Leon et al (2011),Li et al (2013),Liu et al (2017),Lyimo et al (2013),Madu et al (2011), El Maerrawi and Carvalho (2015),Malik et al (2009),Martins et al (2008),Marwa et al (2015),Mathur et al (2013),Mawalla et al (2011),Mehrabi Bahar et al (2015),Memon et al (2013),Mundhada and Tenpe (2015),Nagaya et al (2017),Ng et al (2015),Ning et al (2014),Nwankwo and Edino (2014),Oliveira and Carvalho (2004),Pardhan et al (2013), Porras-Hernandez et al (2008,Portillo-Gallo et al (2014),Qi et al (2013),Qin et al (2014),Qiu et al (2011),Rabiu ...…”

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confidence: 99%

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Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Curcio

Cané

Fernández³

et al. 2019

International Journal of Infectious Diseases

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Background: Surgical site infection (SSI) is both the most frequently studied healthcare-associated infection and the most common healthcare-associated infection in the developing world. A systematic review and meta-analysis was conducted to evaluate the relative size of this burden and to estimate the prevalence of SSI in clean and clean-contaminated surgeries in a large sample of countries in the developing world. Methods: A systematic search of the MEDLINE/PubMed, Scopus, and LILACS databases was conducted to identify studies providing the prevalence of SSI in elective clean and clean-contaminated surgeries in 39 countries or regions around the world. Data of interest were limited to publications from January 2000 to December 2017. Studies with information on the number of cases of SSI and number of total elective clean and clean-contaminated surgeries during the same period were included in this evaluation. Studies lacking clear definition of the total number of exposed patients were excluded. Results: Based on the combined data from the 99 articles evaluated in this analysis, the overall prevalence of SSI in elective clean and clean-contaminated surgeries was estimated to be 6% (95% confidence interval (CI) 5-7%). This increased to 15% (95% CI 6-27%) when considering only those reports with post-discharge surveillance data. The overall prevalence of SSI in Africa/Middle East, Latin America, Asia, and China was 10% (95% CI 6-15%), 7% (95% CI 5-10%), 4% (95% CI 4-5%), and 4% (95% CI 2-6%), respectively. Significant variability in the data was confirmed by both the funnel plot and the Egger test (p = 0.008). Conclusions: Although the data are variable, it is clear that the incidence of SSI in the developing world is higher than that in the developed world.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Curcio

Cané

Fernández³

et al. 2019

International Journal of Infectious Diseases

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“…The most frequent organisms found at surgical sites in patients with malignancies are Gram‐positive bacteria, specifically S. aureus , as in the general population. However, the rates of MRSA infections can be higher in patients with cancer than in those without cancer (up to 40%), and, more recently, different authors have reported higher rates of GNB, P. aeruginosa , ESBL‐producing organisms, and other MDROs, such as VRE . In general, however, the isolated organisms depend on the type of surgery, as shown in a retrospective review from The University of Texas MD Anderson Cancer Center (MD Anderson), where S. aureus was the predominant organism in SSIs after breast cancer surgery, thoracotomy, craniotomy, and abdominal/pelvic surgery; however, 42% of SSIs were polymicrobial, with P. aeruginosa and E. coli being the predominant organisms among the GNBs .…”

Section: Preventing Infectionmentioning

confidence: 99%

Update on infection control practices in cancer hospitals

Ariza-Heredia

Chemaly

2018

CA A Cancer J Clinicians

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Therapies in oncology have evolved rapidly over the last years. At the same pace, supportive care for patients receiving cancer therapy has also evolved, allowing patients to safely receive the newest advances in treatment in both an inpatient and outpatient basis. The recognition of the role of infection control and prevention (ICP) in the outcomes of patients living with cancer has been such that it is now a requirement for hospitals and involves multidisciplinary groups. Some unique aspects of ICP for patients with cancer that have gained momentum over the past few decades include catheter-related infections, multidrug-resistant organisms, community-acquired viral infections, and the impact of the health care environment on the horizontal transmission of organisms. Furthermore, as the potential for infections to cross international borders has increased, alertness for outbreaks or new infections that occur outside the area have become constant. As the future approaches, ICP in immunocompromised hosts will continue to integrate emerging disciplines, such as antibiotic stewardship and the microbiome, and new techniques for environmental cleaning and for controlling the spread of infections, such as whole-genome sequencing. CA Cancer J Clin 2018;000:000-000. © 2018 American Cancer Society.

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“…These guidelines on hygiene are based on the assumption that microbes contaminating the operative field cause surgery-associated infections (3)(4)(5). However, the phylogenetic signature of bacteria isolated from surgical sites, draining lymph nodes, and from sites distant from the operative field includes largely enteric bacterial species that may suggest an intestinal origin for such infections (2,6,7).…”

Section: Introductionmentioning

confidence: 99%

Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery

Jakob

Sánchez-Taltavull

Yılmaz

et al. 2019

Preprint

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Infections after surgical interventions are assumed to be caused by contamination. We show by analyzing multicentric data of 6561 patients that surgical infections as well as sepsis had a predominantly enteric microbial signature irrespective of the type of surgery, suggesting failure of intestinal bacterial compartmentalization. In mice, we reveal that hepatic surgery induced dysregulation of intestinal and hepatic type 3 innate lymphoid cells (ILC3s) and intestinal leakage resulting in enteric bacterial translocation via lymphatic vessels. In the absence of hepatic ILC3s, inflammasome activation and the induction of antimicrobial peptide encoding genes, bacteria colonized remote systemic organs and impaired surgical outcomes. Conversely, mammalian-microbial commensalism is required for the education of host immunity to ensure optimal hepatic healing responses. In fact, microbial-derived products were sufficient for the induction of proliferative transcriptional networks in the mouse liver, as illustrated by serum transfer experiments, mass spectrometry and RNA expression analysis, indicating that the balanced exposure of the host to commensals is essential for recovery. This study reveals the intestinal origin of microbes causing complications after surgical interventions and highlights host protective mechanisms of controlled commensalism that prevent infections.

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Microbiology of surgical site infections in patients with cancer: A 7-year review

Cited by 20 publications

References 24 publications

Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Surgical site infection in elective clean and clean-contaminated surgeries in developing countries

Update on infection control practices in cancer hospitals

Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery

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