Microbiology of specimens obtained by laparoscopy from controls and from patients with pelvic inflammatory disease or infertility with tubal obstruction: Chlamydia trachomatis and Ureaplasma urealyticum

Henry-Suchet, J; Catalán, F; Loffredo, V.; Serfaty, D.; Siboulet, A; Pérol, Y; Sanson, M.J.; Debache, C.; Pigeau, F; Coppin, R; Brux, J. De; Poynard, Thierry

doi:10.1016/0002-9378(80)91100-x

Cited by 101 publications

(13 citation statements)

References 9 publications

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“…Undifferentiated Ureaplasma spp . have been cross-sectionally associated with PID and infertility,18 although not consistently 6. Recently, the two biovars of Ureaplasma urealyticum have been classified as separate species:19 U. urealyticum , which has been associated with urethritis in men and Ureaplasma parvum that has not 20…”

Section: Introductionmentioning

confidence: 99%

Identification of novel microbes associated with pelvic inflammatory disease and infertility

et al. 2016

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ObjectivesAs pelvic inflammatory disease (PID) aetiology is not completely understood, we examined the relationship between select novel bacteria, PID and long-term sequelae.MethodsFastidious bacterial vaginosis (BV)-associated bacteria (Sneathia (Leptotrichia) sanguinegens, Sneathia amnionii, Atopobium vaginae and BV-associated bacteria 1 (BVAB1)), as well as Ureaplasma urealyticum and Ureaplasma parvum were identified in cervical and endometrial specimens using organism-specific PCR assays among 545 women enrolled in the PID Evaluation and Clinical Health study. Risk ratios and 95% CIs were constructed to determine associations between bacteria, histologically confirmed endometritis, recurrent PID and infertility, adjusting for age, race, gonorrhoea and chlamydia. Infertility models were additionally adjusted for baseline infertility.ResultsPersistent detection of BV-associated bacteria was common (range 58% for A. vaginae to 82% for BVAB1) and elevated the risk for persistent endometritis (RRadj 8.5, 95% CI 1.6 to 44.6) 30 days post-cefoxitin/doxycycline treatment, independent of gonorrhoea and chlamydia. In models adjusted for gonorrhoea and chlamydia, endometrial BV-associated bacteria were associated with recurrent PID (RRadj 4.7, 95% CI 1.7 to 12.8), and women who tested positive in the cervix and/or endometrium were more likely to develop infertility (RRadj 3.4, 95% CI 1.1 to 10.4). Associations between ureaplasmas and PID sequelae were modest.ConclusionsTo our knowledge, this is the first prospective study to demonstrate that S. sanguinegens, S. amnionii, BVAB1 and A. vaginae are associated with PID, failure of the Centers for Disease Control and Prevention-recommended treatment to eliminate short-term endometritis, recurrent PID and infertility. Optimal antibiotic regimens for PID may require coverage of novel BV-associated microbes.

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Section: Introductionmentioning

confidence: 99%

Identification of novel microbes associated with pelvic inflammatory disease and infertility

et al. 2016

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“…Thus in the original series from Sweden, C. trachomatis was recovered from the fallopian tubes at laparoscopy in 30% of cases of PID (Mardh et al 1977); in subsequent reports the incidence of tubal isolation ranged from 24% in France (Henry-Suchet et al 1980) to nil in San Francisco (Sweet et al 1980). This variation probably reflects the difference in the severity of the disease rather than a variation in the rate of chlamydial infection; women undergoing laparoscopy for pelvic inflammatory disease in Sweden would seem on average to be less ill than those in the USA.…”

Section: Infertilitymentioning

confidence: 97%

“…However Henry-Suchet et al (1980) reported the isolation of C. trachomatis from active infection of the tubes in 26% of women with occlusive infertility, a higher isolation rate than from women with acute PID. Paavonen et al (1979a) recovered C. trachomatis from the cervices of 10 of 51 women with nonocclusive infertility: this was over twice the incidence in the general population.…”

Section: Infertilitymentioning

confidence: 98%

Long-Term Complications of Infection of the Female Genital Tract by Intracellular Sexually-Transmitted Microorganisms: A Review

Hare

1983

J R Soc Med

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“…Pelvic inflammatory disease is the most common cause of distal tubal disease, but it may at times result from endometriosis. 460,461 We believe that the diagnosis of hydrosalpinx should be made on visualizing dilated tubes on ultrasound at midcycle. This nuance is important, as it is commonly held that hydrosalpinges must be removed (salpingectomy) to optimize IVF outcome.…”

Section: The Fallopian Tubesmentioning

confidence: 99%

Pelvic Imaging in Reproductive Endocrinology

Ziegler¹,

Streuli²,

Santulli³

et al. 2014

Yen &Amp; Jaffe's Reproductive Endocrinology

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Microbiology of specimens obtained by laparoscopy from controls and from patients with pelvic inflammatory disease or infertility with tubal obstruction: Chlamydia trachomatis and Ureaplasma urealyticum

Cited by 101 publications

References 9 publications

Identification of novel microbes associated with pelvic inflammatory disease and infertility

Identification of novel microbes associated with pelvic inflammatory disease and infertility

Long-Term Complications of Infection of the Female Genital Tract by Intracellular Sexually-Transmitted Microorganisms: A Review

Pelvic Imaging in Reproductive Endocrinology

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