Microbiology of pyogenic liver abscess.

Moore-Gillon, J; Eykyn, S J; Phillips, Ian

doi:10.1136/bmj.283.6295.819

Cited by 91 publications

(29 citation statements)

References 19 publications

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“…In these cases PLA, the predominant organism were E. Coli 5(50%) and other organism Proteus 3(30%) Pseudomonas and Klebsiella each 1(10%). These studies are in agreement with Moore et al (1993) in U.K, McDonald (1984) 3 in Australia, Sherlock et al (1993) in U.K, they found E. Coli as the Commonest organism [22][23][24] . In contrast Yeah et.al (1997) in Singapore, reported Klebsiella Pneumoniae as the commonest organism in PLA 25 .…”

Section: Discussionsupporting

confidence: 82%

A Cross Sectional Descriptive Study of Etiology and Clinical Pattern of Liver Abscess : 50 Cases

Das¹,

Majumdar²,

Das³

et al. 2013

Chatt Maa Shi Hosp Med Coll J

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Background: The liver is the organ most subjected to the development of abscesses and made up 48 % of all visceral abscesses' and 7% of all intra abdominal abscesses. Liver abscess should be suspected when there is a combination of fever, leucocytosis, constitutional symptoms, and pain in the right upper quadrant, and tenderness over the liver or right lower rib cage. The liver is affected by a number of local and disseminated infections; their frequency and types vary considerably around the world. Parasitic disorders are more prevalent in developing countries. Methods: It was a cross-sectional descriptive study. The cases were taken from the admitted patients of Medicine unit of SMCH, Chittagong. The study was conducted over a period of one year with a sample size of 50 patients and sample was taken by purposive sampling. Results: Among 50 patients 40 (80%) were diagnosed as ALA and 10 (20%) were diagnosed as PLA. ALA cases are common in 21-30 years age group & PLA cases are more common in >50 years of age group. Majority of the cases were from rural area. Common clinical features were fever, abdominal pain, nausea and tender hepatomegaly. Diarrhea was present on admission in 7 (15.9%) patients of ALA. Anaemia was common in both but polymorphonuclear leucocytosis was moderate to severe in PLA. Microscopic examination of stool samples for E. Histolytica trophozoites was positive in 3 (7.5%) cases and cysts in 4(10%) cases. Nine patients had right sided pleural effusion. Conclusions: Clinical features are common in both ALA and PLA. Liver abscesses are more common in men and more prevalent in rural areas. ALA more commonly occurs in 21-30 years age group but can occur at any age. Pyogenic abscess is more common in older age group (>50 years) and E. Coli is the commonest organism.

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Section: Discussionsupporting

confidence: 82%

A Cross Sectional Descriptive Study of Etiology and Clinical Pattern of Liver Abscess : 50 Cases

Das¹,

Majumdar²,

Das³

et al. 2013

Chatt Maa Shi Hosp Med Coll J

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“…"S. milleri" has been implicated in other reports as a cause of brain abscess (51) and meningitis (39,72). "S. milleri" also functions as a pathogen in pyogenic liver abscess (9,40,54,59) and appendicitis (49,61). Mannitol-fermenting "S. milleri," frequently isolated from the female genital tract, has been implicated in two cases of neonatal sepsis (16).…”

Section: Clinical Significance Of "S Milleri"mentioning

confidence: 99%

“…Although often isolated in pure culture, "S. milleri" can be found in polymicrobial infections (44,54,68,76,79). This raises the possibility of synergistic infections involving S. milleri, but this phenomenon has yet to be investigated.…”

Section: Clinical Significance Of "S Milleri"mentioning

confidence: 99%

Streptococcus anginosus ("Streptococcus milleri"): the unrecognized pathogen

1988

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"Streptococcus milleri" is an unofficial name that has been applied to a group of streptococci which, although basically similar, show various hemolytic, serological, and physiological characteristics. The species name Streptococcus anginosus has recently been recognized as the approved name for these organisms. Streptococci known as "S. milleri" have been implicated as etiologic agents in a variety of serious purulent infections, but because of their heterogeneous characteristics, these organisms may be unrecognized or misidentified by clinical laboratorians. This review describes the bacteriological aspects of organisms known as "S. milleri," their clinical significance, and the problems encountered with their identification in the clinical laboratory.

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“…In a recent population-based epidemiological study it was observed that members of the SMG were responsible for as many invasive streptococcal diseases as all other streptococci combined (25). The members of the SMG are also the most common cause of brain (10,13) and liver (12,28) abscesses. Furthermore, members of the SMG are recognized respiratory pathogens.…”

mentioning

confidence: 99%

Macrolide and Clindamycin Resistance inStreptococcus milleriGroup Isolates from the Airways of Cystic Fibrosis Patients

Grinwis¹,

Sibley²,

Parkins

et al. 2010

Antimicrob Agents Chemother

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Organisms belonging to the Streptococcus milleri group (SMG) are known for their role in pyogenic infections but have recently been implicated as etiological agents of pulmonary exacerbation in adult patients with cystic fibrosis (CF). The prolonged exposure of CF patients to antibiotics prompted us to investigate the susceptibility profiles of 118 SMG isolates from the airways of CF patients to 12 antibiotics compared to 43 SMG isolates from patients with invasive infections. We found that ϳ60% of all isolates failed to grow using the standard medium for disc diffusion, Mueller-Hinton blood agar (MHBA), so we explored the usefulness of brain heart infusion (BHI) agar for susceptibility testing. Zone-of-inhibition comparisons between BHI and MHBA showed strong correlations for six antibiotics, and interpretations were similar for both medium types. For ceftriaxone and cefepime, both groups of isolates were highly susceptible. Tetracycline resistance levels were comparable between the two groups (22% in CF isolates and 17.4% in invasive isolates). However, more than half of the CF isolates were not susceptible to azithromycin, erythromycin, and clindamycin, compared to 11%, 13%, and 6.5% of invasive isolates, respectively. There were 5-fold and 8-fold increased risks of azithromycin and clindamycin resistance, respectively, for the isolates from the airways of CF patients relative to the invasive isolates. Macrolide resistance was strongly linked to chronic azithromycin therapy in CF patients. This study shows that BHI agar is a suitable alternative for antimicrobial susceptibility testing for the SMG and that SMG isolates from the airways of CF patients are more resistant to macrolides and clindamycin than strains isolated from patients with invasive infections.The members of the Streptococcus milleri group (SMG; also known as the Streptococcus anginosus group), consisting of Streptococcus anginosus, Streptococcus constellatus, and Streptococcus intermedius, are considered commensal organisms notable for their tendency to cause pyogenic infections (33). In a recent population-based epidemiological study it was observed that members of the SMG were responsible for as many invasive streptococcal diseases as all other streptococci combined (25). The members of the SMG are also the most common cause of brain (10, 13) and liver (12, 28) abscesses. Furthermore, members of the SMG are recognized respiratory pathogens. The members of the SMG are commonly associated with pleural empyema (1, 24, 31), especially as a complication of community-acquired pneumonia (1,35,45,48), and there is evidence that the SMG members are a cause of "culturenegative" community-acquired pneumonia (21). Recent studies have shown that the SMG may be an intrinsic component of the cystic fibrosis (CF) airway microbiome, with a high carriage rate observed for the sputum of adult CF patients (20,36,37). Moreover, members of the SMG were implicated in a large proportion of pulmonary exacerbations requiring hospitalization of adults with CF (29,36,3...

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Microbiology of pyogenic liver abscess.

Cited by 91 publications

References 19 publications

A Cross Sectional Descriptive Study of Etiology and Clinical Pattern of Liver Abscess : 50 Cases

A Cross Sectional Descriptive Study of Etiology and Clinical Pattern of Liver Abscess : 50 Cases

Streptococcus anginosus ("Streptococcus milleri"): the unrecognized pathogen

Macrolide and Clindamycin Resistance inStreptococcus milleriGroup Isolates from the Airways of Cystic Fibrosis Patients

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