Microbiology of Odontogenic Bacteremia: beyond Endocarditis

Expressions of Interleukin-1β and Interleukin-6 Within Aortas and Uteri of Rats with Various Severities of Ligature-Induced Periodontitis

“…Immunohistochemistry data further confirmed these results. Previous studies have demonstrated that periodontal pathogens invade uterus and fetoplacental tissue [11,33,46,47], bacterial products disrupt the normal immune and inflammatory statuses of host cells and tissues [37,48], cytokines play a role in the course of physiological labour [33,37] and elevated local expressions of IL-1β and IL-6 in uterine tissues are responsible for enhanced prostaglandin production, thus hastening membrane rupture and delivery [49]. In this sense, excessive bacterial loads might result in significantly elevated expressions of IL-1β and IL-6 within the uteri of rats with moderate or severe periodontitis.…”

“…Although periodontitis is considered to be an oral problem, over the past decades, the potential associations between periodontitis with atherosclerosis [1][2][3][4][5] and preterm labour [4,[6][7][8][9][10][11] have drawn exceeding attention. Epidemiological research has identified a correlation between periodontitis and these systemic diseases, but not causation [3,6].…”

A systematic review and meta-analysis of clinical, microbiological, and behavioural aspects of oral health among patients with stroke

“…gingivitis, periodontitis and dental caries), but also serious systemic health problems such as bacteremia. 12,13 Aspiration pneumonia is one the most common and serious post-stroke infection accounting for an estimated one third of post-stroke mortalities and leading to the need for prolonged stroke rehabilitation. [14][15][16] Preliminary evidence among institutionalized elders suggests the link between aspiration pneumonia and oral health conditions: caries, periodontal disease, and poor hygiene.…”

65-Year-Old Woman With Confusion

“…10 An important aspect of the features of the oral biofilm is its close proximity to highly vascularized tissue beds as compared with flora of the skin, for example, which have a thick barrier to the closest vascular supply. 12 This makes the disruption of the available defenses against these colonizers a serious threat that may lead to bacteremia and other consequences depending on the host risk factors.…”

“…11 In the event of plaque buildup with proliferation of the biofilms, conditions such as gingivitis and periodontitis develop. 12 These conditions and perhaps many other inflammatory disorders of the periodontal spaces lead to periodontal vascular proliferation, which increases the periodontal vasculature surface area and makes it easier for overlying bacteria to gain access to the bloodstream and cause subsequent complications. 12 These inflammatory or infectious conditions also disrupt the other defense barriers.…”