Microbiology, Lens Care and Maintenance

Williams, Lewis; Stapleton, Fiona; Carnt, Nicole

doi:10.1016/b978-0-7020-7168-3.00004-0

Cited by 5 publications

(8 citation statements)

References 123 publications

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“…Silicone hydrogel (SIHy) contact lenses containing lipophilic silicone-based polymers such as poly(dimethyl siloxane) and tris (trimethylsiloxy) methacryloxy propyl silane (TRIS) are highly susceptible to lipid deposition and protein denaturation at the tear film–lens surface interface [ 145 , 146 , 147 ]. This, coupled with the inherent hydrophobicity and mechanical strength of SIHy lenses, contributes to decreased surface wettability, ocular irritation, and overall patient discomfort.…”

Section: Hyaluronic Acid Biomaterials For Ocular Drug Deliverymentioning

confidence: 99%

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes

et al. 2022

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Extensive research is currently being conducted into novel ocular drug delivery systems (ODDS) that are capable of surpassing the limitations associated with conventional intraocular anterior and posterior segment treatments. Nanoformulations, including those synthesised from the natural, hydrophilic glycosaminoglycan, hyaluronic acid (HA), have gained significant traction due to their enhanced intraocular permeation, longer retention times, high physiological stability, inherent biocompatibility, and biodegradability. However, conventional nanoformulation preparation methods often require large volumes of organic solvent, chemical cross-linkers, and surfactants, which can pose significant toxicity risks. We present a comprehensive, critical review of the use of HA in the field of ophthalmology and ocular drug delivery, with a discussion of the physicochemical and biological properties of HA that render it a suitable excipient for drug delivery to both the anterior and posterior segments of the eye. The pivotal focus of this review is a discussion of the formation of HA-based nanoparticles via polyelectrolyte complexation, a mild method of preparation driven primarily by electrostatic interaction between opposing polyelectrolytes. To the best of our knowledge, despite the growing number of publications centred around the development of HA-based polyelectrolyte complexes (HA-PECs) for ocular drug delivery, no review articles have been published in this area. This review aims to bridge the identified gap in the literature by (1) reviewing recent advances in the area of HA-PECs for anterior and posterior ODD, (2) describing the mechanism and thermodynamics of polyelectrolyte complexation, and (3) critically evaluating the intrinsic and extrinsic formulation parameters that must be considered when designing HA-PECs for ocular application.

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Section: Hyaluronic Acid Biomaterials For Ocular Drug Deliverymentioning

confidence: 99%

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes

et al. 2022

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“…Factors known to cause rapid deposition on the lens include concurrent dry eye, meibomian gland dysfunction, and systemic disease. 3 In an oculoplastic setting, therapeutic CLs have been commonly used for cornea protection and enhance patient comfort on September 18, 2022 by guest. Protected by copyright.…”

Section: Descriptionmentioning

confidence: 99%

“…Senofilcon-A CLs used for extended wear have higher oxygen transmissibility however they also have higher propensity for jelly-bump deposition compared with conventional soft CL. Factors known to cause rapid deposition on the lens include concurrent dry eye, meibomian gland dysfunction, and systemic disease 3. In an oculoplastic setting, therapeutic CLs have been commonly used for cornea protection and enhance patient comfort following ptosis repair 4.…”

Section: Descriptionmentioning

confidence: 99%

Giant jelly bump deposits on therapeutic contact lens: an unusual finding following ptosis surgery

et al. 2022

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The authors report two cases of unusually large deposits on their therapeutic bandage contact lens (BCL) following uneventful surgery for congenital ptosis. The first case presented at 6 weeks with decreased vision, large jelly-bump deposits over the contact lens and sterile corneal infiltrates. The infiltrates rapidly resolved with restoration of vision following contact lens removal and topical antibiotics. The second case presented 2 weeks after surgery with visual loss and similar deposits but with no corneal involvement. Following replacement of BCL and topical lubricants, her vision improved to 20/20. Studies on the role of BCL in ptosis surgery are scarce with literature supporting its use for ocular surface protection and minimising postoperative discomfort. The authors hypothesise impaired blink mechanism as the accelerating factor for this unusual occurrence in the early postoperative period and recommend frequent replacement of the contact lens and a closer follow-up in all these cases.

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“…The main bacterial infection source of microorganisms attached on SCL includes hands [ 79 ], eyelids [ 80 ], lens care solutions [ 81 ], and storage cases [ 82 ]. Common pathogenic bacteria [ 83 ] involved in ophthalmology bacterial infection include P. aeruginosa , S. aureus , S. marcescens , and Acanthamoeba spp.…”

Section: Prospects For the Development Of Biomimetic Bactericidal mentioning

confidence: 99%

“…As a hydrophilic surface immersed in the interface between an aquatic environment and the atmosphere, SCL are not only a barrier between the corneal epithelium and oxygen, but also an optimal hotbed of bacterial incubation. In previous studies in SCL biofouling [ 16 , 67 , 68 , 70 , 73 , 74 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ], the relationship between SCL physical properties and susceptibility to microbial adsorption have been discussed and analyzed to conceive specialized antibacterial strategies.…”

Section: Prospects For the Development Of Biomimetic Bactericidal mentioning

confidence: 99%

Biomimetic Functional Surfaces towards Bactericidal Soft Contact Lenses

Mao

2020

Micromachines

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The surface with high-aspect-ratio nanostructure is observed to possess the bactericidal properties, where the physical interaction between high-aspect-ratio nanostructure could exert sufficient pressure on the cell membrane eventually lead to cell lysis. Recent studies in the interaction mechanism and reverse engineering have transferred the bactericidal capability to artificial surface, but the biomimetic surfaces mimicking the topographical patterns on natural resources possess different geometrical parameters and surface properties. The review attempts to highlight the recent progress in bactericidal nanostructured surfaces to analyze the prominent influence factors and cell rupture mechanism. A holistic approach was utilized, integrating interaction mechanisms, material characterization, and fabrication techniques to establish inclusive insights into the topographical effect and mechano-bactericidal applications. The experimental work presented in the hydrogel material field provides support for the feasibility of potentially broadening applications in soft contact lenses.

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Microbiology, Lens Care and Maintenance

Cited by 5 publications

References 123 publications

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes

Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes

Giant jelly bump deposits on therapeutic contact lens: an unusual finding following ptosis surgery

Biomimetic Functional Surfaces towards Bactericidal Soft Contact Lenses

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