Microbiological investigation of a hospital outbreak of invasive group A streptococcal disease in Krakow, Poland

Strus, Magdalena; Drzewiecki, Artur; Chmielarczyk, Agnieszka; Tomusiak, Anna; Romanek, P.; Kosowski, Krzysztof; Kochan, Piotr; Linden, Mark van der; Lütticken, Rudolf; Heczko, Piotr B

doi:10.1111/j.1469-0691.2010.03139.x

Cited by 6 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hands have not been emphasized as a target of sampling in some investigations of GAS infection outbreaks [4,[10][11][12][13]. Also, in the recommendations from the CDC, hands are not included as a target of investigation [1].…”

Section: Discussionmentioning

confidence: 99%

Outbreak of Infections Caused by Group AStreptococcusafter Modified Radical Mastectomy

Qing-Zeng

Yun-Bo²,

Liu³

et al. 2013

Surgical Infections

View full text Add to dashboard Cite

Background: Eight infections occurred after modified radical mastectomies in a tertiary-care hospital. Group A streptococci (GAS) were isolated from three of the eight patients. Methods: To control the outbreak, an epidemiologic investigation was conducted, and healthcare workers were screened for pathogens. Strains isolated from healthcare workers were compared with patient strains by emm typing. Results: One surgeon attended one of the eight operations and observed the other seven. Streptococcus strains from the hands of this surgeon were identical to the patient strains. After the surgeon was suspended from duty and underwent eradication treatment, the outbreak was controlled. Conclusions: This outbreak of GAS infection is believed to have occurred by airborne transmission. Suspending patient care by healthcare workers who carry the causative GAS in a site(s) other than the respiratory tract for only the first 24 h they are receiving chemoprophylaxis may not be long enough. Sampling of the hands of healthcare workers during an investigation of nosocomial GAS infection is valuable.

show abstract

Section: Discussionmentioning

confidence: 99%

Outbreak of Infections Caused by Group AStreptococcusafter Modified Radical Mastectomy

Qing-Zeng

Yun-Bo²,

Liu³

et al. 2013

Surgical Infections

View full text Add to dashboard Cite

show abstract

“…Although outbreaks outside the familial setting have markedly decreased in frequency and magnitude, they continue to occur, especially in closed communities such as daycare centres or military units [1, 2]. Nosocomial S. pyogenes transmission has been also well documented and, although most reports describe transmission from asymptomatic healthcare workers (HCWs) to patients [3–5], transmission from patients to HCWs has also been described [6–8]. Paediatric intensive care units (PICUs) are a recent creation where hygiene standards are high, explaining why, with some exceptions [9], no S. pyogenes outbreaks have hitherto been described in these units.…”

mentioning

confidence: 99%

“…There were no asymptomatic infections, probably because the infecting dose transmitted by the patient was very high. The high transmissibility of S. pyogenes has been shown by the frequent occurrence of secondary cases detected in asymptomatic individuals [3–5], who probably have an infecting dose or bacterial load far lower than that of persons with symptomatic infection. The fifth HCW, with a distinct S. pyogenes strain than that detected in the index case, probably acquired the infection in the paediatric ED where she worked.…”

mentioning

confidence: 99%

Outbreak of Streptococcus pyogenes infection in healthcare workers in a paediatric intensive care unit: transmission from a single patient

et al. 2012

View full text Add to dashboard Cite

A 15-h stay in a paediatric intensive care unit by a girl with generalized dermal lesions superinfected with Streptococcus pyogenes led to four streptococcal infections in healthcare workers. Phenotypic and molecular analyses of the strains revealed that four isolates, characterized as emm87/ST62/T28, were identical to the isolate obtained from the index case. The occurrence of this outbreak, despite of the girl's brief hospital stay and appropriate patient management, highlights the high transmissibility of this pathogen.

show abstract

Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections

Golińska

Linden

Więcek

et al. 2016

Eur J Clin Microbiol Infect Dis

Self Cite

View full text Add to dashboard Cite

Invasive group A streptococcal (GAS) infections constitute an important epidemiological problem. Many cases occur in women during the postnatal period. The objective of this study was to evaluate the presence of the genes responsible for production of iron-chelating protein (perR) and superantigens (speA, speB, speC, speF, speG, speH, speI, speJ, speK, speL, speM, smeZ, and ssa) in S. pyogenes strains isolated from invasive infections in women after delivery. Furthermore, this study sought to verify whether S. pyogenes strains show special phenotypic and genotypic (sla, spy1325) characteristics that may play a decisive role in adherence to the genital tract epithelium. Moreover, the emm-types and antibiotic susceptibility were determined. We tested 30 invasive S. pyogenes strains isolated from postpartum invasive infection and 37 GAS control strains isolated from the genital tracts of asymptomatic multiparous women. The majority of the tested strains were shown to express two types of emm genes (1 and 28), though emm −12, −28, −75 and −89 were uniquely expressed in the group of strains isolated from invasive infections. A significantly higher prevalence of perR in the strains from puerperal fever was shown. Significant differences were also found between the two groups with respect to the incidence of the genes related to adherence; GAS strains originating from women with sepsis/puerperal fever showed presence of these genes less frequently than those of the control group. Although differences in frequencies of the gene coding for various superantigens were noted between the compared groups of GAS strains, they were not significant.

show abstract

Microbiological investigation of a hospital outbreak of invasive group A streptococcal disease in Krakow, Poland

Cited by 6 publications

References 39 publications

Outbreak of Infections Caused by Group AStreptococcusafter Modified Radical Mastectomy

Outbreak of Infections Caused by Group AStreptococcusafter Modified Radical Mastectomy

Outbreak of Streptococcus pyogenes infection in healthcare workers in a paediatric intensive care unit: transmission from a single patient

Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections

Contact Info

Product

Resources

About