Microbiological effects of an antiseptic mouthrinse in irradiated cancer patients

Abstract

Objective: To assess the microbiological effects of an antiseptic, non-alcohol based mouth-rinse containing chlorhexidine and cetylpyridinium chloride, in patients undergoing radiation therapy for head-and-neck cancer. Study Design: This was a parallel, double-blind, prospective, randomized clinical trial, including patients irradiated as part of the therapy of head-and-neck cancer, aged 18-75, with at least 10 teeth, and willing to sign an informed consent. Cancer patients were randomly assigned to one of the two treatments (test mouth-rinse or a placebo). Three visits were scheduled (baseline, 14 and 28 days). Microbiological findings were evaluated in tongue, mucosa and subgingival samples, by means of culture. Microbiological variables were assessed by means of the Mann-Whitney, Wilcoxon and chi-square tests. Results: 70 patients were screened and 36 were included. The detection of Candida species in mucosa and tongue samples showed significant reductions in the test group. Total bacterial counts decreased in both groups from baseline to the 2-week visit, while minor changes occurred between 2 and 4 weeks (effects on P. gingivalis, P. intermedia, C. rectus, E. corrodens). Conclusions: Within the limitations of the small sample size, this study suggests that the use of the tested mouthrinse may lead to improvements in microbiological parameters in patients irradiated for head-and-neck cancer.

Protocols for management of oral complications of chemotherapy and/or radiotherapy for oral cancer: Systematic review and meta-analysis current

“…Associating yourself positively using PerioAid Tratamiento® antiseptic mouthrinse combined with 0,12% of chlorhexidine and 0,05% of cetylpyridinium chloride, in the reduction of Candida spp. colonies in the oral mucosa and tongue, as well as in samples of subgingival periodontal pathogens (P. gingivalis e E. corrodens) during the RT (15) according to the protocol suggested in table 3.…”

“…The degree of homogeneity or heterogeneity of the studies was evaluated by statistical test Chi-square (χ2) resulting in the acceptance of the null hypothesis (H0) in both tests, due the value of P = 0.8985 (homogeneity) and P = 0,5299 (heterogeneity) be ≥ to decision level α=0.01 and α=0.05, respectively. The H0 of both tests applied to studies of this review confirm that the samples are heterogeneous, in this case, is indicated by the data analysis Random Effects Model of DerSimonian-Laird (12) for evaluation of the following Odds Ratio tests (OR) together with the Relative Risk (RR) to quantify the association between the presence of OMP and the effectiveness of managements of EG and CG with confidence interval of 95% (CI 95%) and decision value of OR ( P < 0.05) and RR ( P < 0.01) for statistical significance (13-15). …”

Changes in microflora in dental plaque from cancer patients undergoing chemotherapy and the relationship of these changes with mucositis: A pilot study

“…Topical, oral and parenteral anti microbials before and during cancer chemotherapy should alter the quantitative and qualitative oral micro flora profile (18). For this reason, the use of anti microbial agents was an exclusion criterion for our study.…”

Porphyromonas gingivalispromotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation

“…The oral cavity is comprised of various boundary surfaces such as the gingiva, buccal mucosa, tongue dorsum, lateral side of the tongue, and hard and soft plate, which are all colonized with a diverse microbiota (Aas et al, 2005). Thus, P. gingivalis can continually interact with OSCC cells in these sites, and this pathogen has been shown to occur frequently in the mouth of oral cancer patients (Mager et al, 2005;Lanzós et al, 2011). Furthermore, antigens of P. gingivalis have also been detected in gingival squamous carcinoma tumours (Katz et al, 2011).…”