Microbiologic study of chronic inflammation associated with tubal factor infertility: role of Chlamydia trachomatis

Henry-Suchet, J; Utzmann, Christine; Brux, J. De; Ardoin, P; Catalán, F

doi:10.1016/s0015-0282(16)50005-3

Cited by 52 publications

(24 citation statements)

References 7 publications

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“…Similarly Vogelzang et al 31 , in a study of infertile women referred to an IVF provider for diagnostic laparoscopy, found that 7/33 (21.2%) women with tubal disorders (adhesions, distal occlusions and strictures) demonstrated antibodies to C. trachomatis compared with 0/20 of women without tubal damage. Further studies have also strongly supported the link between serological evidence of previous C. trachomatis infections and tubal infertility and ectopic pregnancies [12][13][14][15] . The detection of antibodies to C trachomatis within fallopian tube washings collected does not necessarily reflect actual antibody production in the tubes but could also be the result of serum transudate or contamination by blood washed through with the dislodged cellular debris and fragments of endometrium.…”

Section: Discussionmentioning

confidence: 76%

“…Most women with tubal infertility do not have a history of recognised acute salpingitis. However, a number of previous studies investigating acute infections, pelvic inflammatory disease and salpingitis have demonstrated that Chlamydia trachomatis and Neisseria gonorrhoeae are the most common causes of such infection [7][8][9][10] ; and others have demonstrated an abnormally high prevalence of antichlamydial (C. trachomatis) antibodies in women with tubal infertility and ectopic pregnancy [11][12][13][14][15] . In this study we investigated the severity of intraluminal disease, endometriosis and evidence for microorganisms associated with PID among a cohort of clinically asymptomatic women undergoing laparoscopy or laparoscopy/falloposcopy for the investigation of infertility.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Debattista

Gazzard²,

Wood³

et al. 2004

Infectious Diseases in Obstetrics and Gynecology

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Background: Cases of endometriosis with no tubal damage are associated with infertility, suggesting an immunological rather than mechanical barrier to reproduction. Laparoscopy and falloposcopy results of clinically asymptomatic women undergoing investigation of infertility were correlated with the outcomes of microbiological screening for Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis, ureaplasma species, Neisseria gonorrhoeae, Neisseria meningitidis and Chlamydia pneumoniae. Methods: A total of 44 women presenting to a hospital IVF service for laparoscopic or laparoscopic/ falloposcopic investigation of infertility provided endocervical swabs, fallopian tube washings, and peripheral whole blood for analysis. Results: Of these 44 women, 15.9% (7) showed evidence of C. trachomatis infection as detected by either PCR or EIA serology. Of these 7 women, 5 (71%) had no or mild endometriosis and 2 (29%) had moderate or severe endometriosis. Of the remaining 37 women who showed no evidence of chlamydial infection, 15 (40.5%) had no or mild endometriosis. Conclusion: Women with infertility, but without severe endometriosis at laparoscopy, showed a trend towards tubal damage and a higher rate of previous C. trachomatis infection. Although not statistically significant, this trend would suggest that, where moderate to severe tubal damage is found to be the primary cause of infertility, C. trachomatis infection could be a likely cause for such tubal damage.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Debattista

Gazzard²,

Wood³

et al. 2004

Infectious Diseases in Obstetrics and Gynecology

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“…trachomatis is considered to be the main etiological agent of pelvic inflammatory disease, being isolated in about 40% of cases (9,11,13,17,19), as well as an important etiological agent of sterility and ectopic pregnancy (4,7,10,25,26); in fact, cultureproven chlamydial infection is found in up to 50% of infertile women.…”

mentioning

confidence: 99%

Chlamydia trachomatis infection in primary unexplained infertility

et al. 1990

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In recent years Chlamydia trachomatis has emerged as a significant cause of acute salpingitis and reproductory failure. In this study, 85 women suffering from primary infertility and 85 parous women as control group were screened for C. trachomatis genital infection by means of cell culture and antigen detection on genital samples as well as the detection of anti-chlamydial antibodies in blood. C. trachomatis was detected in 31.8% of infertile women and 5.8% of fertile subjects. Isolation of C. trachomatis in cell culture proved to be the most reliable diagnostic tool when compared to immunofluorescence staining on smears and serology. Although the latter may be considered of great value in epidemiological researches, culture isolation should be associated for the diagnosis of active infection.

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“…The fact that symptoms of genital chlamydial infections are vague and that they may run a chronic course, e.g. in the fallopian tubes 9,10 , further stress the need for rescreening. The optimal time lag before such controls should be performed is, however, not yet determined.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, in one study nondetectable levels of the drug were found in the morning of the ® fth day after start of such a therapy. Persistence of C. trachomatis in tubal tissue may occur in spite of repeated courses of tetracycline given to cases with chronic tubal infection 9,10 . Such an infection may be detectable by immunohistological staining of tissue sections, but may be undetectable by culture and/or PCR/LCR tests.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Is there a need for rescreening of patients treated for genital chlamydial infections?

Mårdh

Persson

2002

Int J STD AIDS

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Summary:The present communication reviews reasons to perform rescreening of chlamydia-infected persons. It brings up dif® culties to differentiate between relapse and reinfection. Studies on follow-up of chlamydia-positive cases after therapy are reviewed. It also highlights reasons for therapeutic failure, like compliance, pharmacological factors, including poor bioavailability, wrong dose regimens, lack of adherence to drug intake, neglect of partner noti® cation and concomitant therapy in consorts, possible development of resistance to drugs generally prescribed, false negative or false positive diagnostic tests and reinfection from extra-genital not`cured' sites. The review points to the need to establish programmes for routine rescreening of chlamydia-infected persons.

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Microbiologic study of chronic inflammation associated with tubal factor infertility: role of Chlamydia trachomatis

Cited by 52 publications

References 7 publications

Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Interaction of Microbiology and Pathology in Women Undergoing Investigations for Infertility

Chlamydia trachomatis infection in primary unexplained infertility

Is there a need for rescreening of patients treated for genital chlamydial infections?

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