Microbiologic aspects of glomerulonephritis

Rammelkamp, Charles H.

doi:10.1016/0021-9681(57)90122-4

Cited by 47 publications

(6 citation statements)

References 16 publications

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“…However, the presumption that this is a causal relationship has not been fully justified because of the usual lack qf evidence sufficient to exclude preceding Group A streptococcal respiratory infection in patients who present with simultaneous acute nephritis and skin infection. Rammelkamp has indicated that this deficiency is compounded by the frequent tendency of nephritogenic streptococci to produce greening and little or no 8-hemolysis in blood agar, thus leading to confusion with the normal upper respiratory flora (16).…”

Section: Resultsmentioning

confidence: 99%

“…Although this outbreak involved a different Group A streptococcus (type 12), a different site of infection (pharynx), a different age group (young adults), and a uniform population by sex ((all males), the attack rate of nephritis (11.4%) was remarkably close to that reported here for skin infections with Type 49 streptococci in children. Nevertheless, there is indirect evidence that the attack rate of acute nephritis may vary widely after infection with a single nephritogenic type, whether due to bacterial, host, or environmental factors (16). Besides the site of infection, the other factor evident at Red Lake in 1966 was the influence of age; nephritis after Type 49 skin infection developed significantly more often in children younger than 6.5 yr.…”

Section: Resultsmentioning

confidence: 99%

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Attack rates of acute nephritis after Type 49 streptococcal infection of the skin and of the respiratory tract

Anthony¹,

Kaplan²,

Wannamaker³

et al. 1969

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Attack rates of acute nephritis after Type 49 streptococcal infection of the skin and of the respiratory tract

Anthony¹,

Kaplan²,

Wannamaker³

et al. 1969

J. Clin. Invest.

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“…The large number of type 12 strains tested here reflects interest in the association of this type with acute glomerulonephritis (7). When it was first discovered that all the type 12 strains available for testing in this laboratory were leukotoxic, other strains of this type and of other types isolated from nephritic patients were obtained through the kindness of Dr. Charles H. Rammelkamp, Jr., and Dr. Floyd Denny.…”

Section: Occur (3 4)mentioning

confidence: 99%

The Leukotoxic Action of Streptococci

Wilson

1957

The Journal of Experimental Medicine

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P r~s 33 ~o 41(Received for publication, January 7, 1957) This is the third study in a series on the interactions between streptococci and host cells. Previous reports have concerned the egestion of streptococci by phagocytic cells (1), and the failure of streptococci to lose their capacity of resisting phagocytosis after being killed with gentle heat or ultraviolet radiation (2). The present work is concerned with one type of outcome following phagocytosis; namely, the destruction of the phagocytizing leukocytes which occurs when certain strains of streptococci are ingested. This injury will be called here "leukotoxic action," and the pertinent attribute of injurious streptococci will be called "leukotoxicity." It was described by Levaditi in 1918 (3), but has received no attention since that time as far as we have been able to discover.The leukotoxic effect is seen only after intact cocci have been phagocytized. It must not be confused with the action of streptococcal leukocidin, a soluble substance elaborated into the medium by growing cocci, which destroys leukocytes even when all coccal cells have been removed by filtration. Todd has presented impressive evidence indicating that leukocidin and streptolysin O are identical (4).In the present report consideration will be given to the biological characteristics of leukotoxicity, to its distribution among streptococci, its relation to other known streptococcal products, its relationship to virulence and its possible significance in streptococcal disease.

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“…Numerous bacterial (in particular streptococcal) [15,17], parasitic [1], and viral infections of man [4] have been suspected to cause glomerular injury, probably through immunologic mechanisms. Chronic viral infections of ani mals with lymphocytic choriomeningitis virus [11], lactic dehydrogenase virus [10,13], agent of Aleutian disease of mink [14], Coxsackie B4 [18], and other viruses [12] can lead to nephritis on the basis of immune complex disease.…”

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confidence: 99%

Cultures of Renal Biopsies: Outgrowth of Vacuolated and Multinucleated Cells

Fiala¹,

Guze²,

Goldberg³

et al. 1973

Nephron

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This study is concerned with the detectionof overt and latent viruses in explant cultures of renal biopsies from 72 patients with various forms of renal disease. Of the 77 biopsies, 52 grew in culture and five of these developed vacuolization, multinucleated syncytia, or cytoplasmic granules. None of these five patients had evidence of streptococcal involvement. Four had focal or diffuse proliferative glomerular changes in the renal biopsy and three of these had nephrotic syndrome. The two most interesting cases included one patient with hypocomplementemic mesangioproliferative glomerulonephritis and another patient with presumptive evidence of systemic lupus erythematosus. Cultures of the first patient thrived for 6 months and persistently showed vacuolization. Cultures of the second patient developed multinucleated and vacuolated cells and these changes reappeared after passage with supernatant of the original culture. This study confirms the absence of overt viruses in renal biopsy cultures. Although the significance of vacuolated and multinucleated cells in these cultures is at present not clear, such changes are suggestive of the presence of a cytopathic agent.

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Microbiologic aspects of glomerulonephritis

Cited by 47 publications

References 16 publications

Attack rates of acute nephritis after Type 49 streptococcal infection of the skin and of the respiratory tract

Attack rates of acute nephritis after Type 49 streptococcal infection of the skin and of the respiratory tract

The Leukotoxic Action of Streptococci

Cultures of Renal Biopsies: Outgrowth of Vacuolated and Multinucleated Cells

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